Antigens released at schizont burst stimulate <em>Plasmodium falciparum</em>-specific CD4+ T cells from non-exposed donors: potential for... (Publications)
from a non-exposed donor. T cells were able to respond to infected blood at a parasitaemia as low as 0.000003% (comparable to the level at which individuals can first experience symptoms of malaria) and
Tracking a tuberculosis outbreak over 21 years: strain-specific single nucleotide polymorphism-typing combined with targeted whole genome sequencing (Publications)
division into three sub-clusters. Isolates from patients with confirmed epidemiological links differed by 0-11 SNPs. CONCLUSIONS: Strain-specific SNP-genotyping allowed rapid and inexpensive identification of
Activities of N,N' -diarylurea MMV665852 analogs against <em>Schistosoma mansoni</em> (Publications)
(66%) after a single oral dose of 400 mg/kg to S. mansoni-infected mice. Worm burden reductions of 0-43% were observed for the remaining eight compounds tested. In conclusion, several analogs of N,N'
Chemical constituents from <em>Waltheria indica</em> exert <em>in vitro</em> activity against <em>Trypanosoma brucei</em> and <em>T. cruzi</em> (Publications)
Tulahuen C4. The dichloromethane extract from the roots showed the highest activity against T. cruzi (IC50=0.74mug/mL) as well as a good selectivity index (SI value of 35). Based on these results, this extract
How do clinicians prefer cultural competence training? Findings from the DSM-5 cultural formulation interview field trial (Publications)
age was associated with a preference for behavioral simulations: OR = 1.05 (95 % CI: 1.01-1.10; p = 0.025). CONCLUSIONS: Most clinicians preferred active behavioral simulations in cultural competence training
In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in <em>Plasmodium... (Publications)
thapsigargin with OZ277, artemether or artesunate, against NF54 and K1 strains of P. falciparum ranged from 0.9 to 1.4. CONCLUSION: The interaction of thapsigargin with OZ277, artesunate or artemether was additive
Measurement of overall insecticidal effects in experimental hut trials (Publications)
alternative definition for the measurement of the overall insecticidal effect has the desirable range of 0 to 1 (100%), provided mortality among non-repelled mosquitoes in the treated hut is less than the c
Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications (Publications)
nets (ITNs); 68% in Ifakara and zero in Manhica. In Ifakara, IPTi was associated with a 53% (95% CI 14.0; 74.1) reduction in the risk of clinical malaria between the second and the third dose; during the same
Adenosine kinase of <em>T. b. Rhodesiense</em> identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical... (Publications)
razol-3-yl]morpholine (compound 1) exhibits specific antitrypanosomal activity with an IC(50) of 1.0 microM on Trypanosoma brucei rhodesiense (T. b. rhodesiense), the causative agent of the acute form
Diagnosis, treatment and risk factors of <em>Strongyloides stercoralis</em> in schoolchildren in Cambodia (Publications)
infected with S. stercoralis. The sensitivity of KAP culture and Baermann technique was 88.4% and 75.0%, respectively and their negative predictive values were 96.4% and 92.5%, respectively. The cumulative
