Macyranones: structure, biosynthesis, and binding mode of an unprecedented epoxyketone that targets the 20S proteasome (Publications)
against the parasites Trypanosoma brucei rhodesiense and Leishmania donovani with IC50 values of 1.55 and 0.22 muM, respectively
Prevalence and factors associated with convulsive status epilepticus in Africans with epilepsy (Publications)
ACE among the general population across the 3 sites was 2.3 per 1,000, and differed with site (p < 0.0001). Over half (55%) of CSE occurred in febrile illnesses and focal seizures were present in 61%.
Screening for pulmonary tuberculosis in Tanzanian prison and computer-aided interpretation of chest X-rays (Publications)
better than CAD4TB, three were comparable, and two performed significantly worse (area under the curve 0.75 in receiver operating characteristics analysis). On a superset of 1321 CXRs, CAD4TB successfully
Clonal waves of <em>Neisseria</em> colonisation and disease in the African meningitis belt: eight- year longitudinal study in Northern Ghana (Publications)
the colonisation isolates. The overall meningococcal colonisation rate of the study population was 6.0%. All culture-confirmed patient isolates and the majority of carriage isolates were associated with
<em>Plasmodium falciparum</em> msp1, msp2 and glurp allele frequency and diversity in Sub-Saharan Africa (Publications)
endemicity namely Malawi, Tanzania, Uganda, Burkina Faso and Sao Tome. METHODS: A total 780 baseline (Day 0) blood samples from children less than seven years, recruited in a randomized controlled clinical trials
Social and cultural features of cholera and shigellosis in peri-urban and rural communities of Zanzibar (Publications)
often by rural respondents. Rural women had more difficulty (20%) to identify a cause than men (7.1%, p=0.016). Peri-urban self treatment emphasised rehydration; the rural community preferred herbal treatment
Rapid urban malaria appraisal (RUMA) II: epidemiology of urban malaria in Dar es Salaam (Tanzania) (Publications)
in Dar es Salaam during a dry spell in 2003 showed that the prevalence of malaria parasites was low: 0.8%, 1.4%, 2.7% and 3.7% in the centre, intermediate, periphery and surrounding rural areas, respectively
Scope and limits of an anamnestic questionnaire in a control-induced low-endemicity helminthiasis setting in south-central Côte d'Ivoire (Publications)
prevalences of hookworm, Trichuris trichiura, Schistosoma haematobium, and Schistosoma mansoni of 39.0%, 2.7%, 2.1%, and 2.1%, respectively. No Ascaris lumbricoides infection was found. Helminth infection
Modelling the geographical distribution of soil-transmitted helminth infections in Bolivia (Publications)
on T. trichiura. Hookworm is sensitive to temperature during the coldest month. We estimate that 38.0%, 19.3%, and 11.4% of the Bolivian population is infected with A. lumbricoides, T. trichiura, and hookworm
Potential risk of regional disease spread in west Africa through cross-border cattle trade (Publications)
movements and the risk of regional disease spread assessed. More than three quarters (79.2%, range: 78.1-80.0%) of cattle flowing into the market system originated from other countries. Through the cattle market
