Programmatic diagnostic accuracy and clinical utility of Xpert MTB/XDR in patients with rifampicin-resistant tuberculosis in Georgia (Publications)
(95% CI, 95.6%-100%). When indeterminate/invalid Xpert MTB/XDR results were included, 17.4% (8/46) and 6.2% (8/129) of patients with phenotypic fluoroquinolone and isoniazid resistance were missed. Median [...] RESULTS: An overall 140 patients were tested with Xpert MTB/XDR and phenotypic DST, and 94.9% and 33.8% had isoniazid and fluoroquinolone resistance by phenotypic DST, respectively. Xpert MTB/XDR showed
Regioselective synthesis of potential non-quinonoid prodrugs of plasmodione: antiparasitic properties against two hemoglobin-feeding parasites and... (Publications)
aromaticity-found in 1,4-naphthoquinones-is broken by the introduction of an angular methyl at C-4a or -8a. This series was designed to act as prodrugs of 1,4-naphthoquinones in an oxidative environment. F [...] acid-based quinones 25 and 27 in the presence of 1-methoxy-1,3-butadiene, to generate the 4a- and the 8a-Ψ-plasmodione regioisomers 1 and 2 (synthesized in six steps with a total yield of 10.5% and 4.1%, [...] and LC-MS analyses were undertaken to reveal the generation of plasmodione...
International study of childhood leukemia in residences near electrical transformer rooms (Publications)
1.9) for intermediate and 1.1 (95% CI: 0.3, 3.8) for high exposure in the conditional logistic model. In the mixed logistic model, RRs were 1.4 (95% CI: 0.8, 2.5) for intermediate and 1.3 (95% CI: 0.4, [...] influential country showed RRs of 1.1 (95% CI: 0.5, 2.4) and 1.7 (95% CI: 0.4, 7.2) for intermediate (8 cases) and high (2 cases) exposure. DISCUSSION: Overall, evidence for an elevated risk was weak. However
Brief research report: quantitative analysis of potential coronary microvascular disease in suspected long-COVID syndrome (Publications)
(MBF) was significantly lower [31.8 +/- 5.1 vs. 37.8 +/- 6.0 (mul/g/beat), P < 0.001] and the T2 relaxation time was significantly higher (46.2 +/- 3.6 vs. 42.7 +/- 2.8 ms, P = 0.002) post-COVID-19 compared
Systematic review and meta-analysis of integrated studies on antimicrobial resistance genes in Africa - a One Health perspective (Publications)
sul1 (36.2%), sul2 (32.0%), tetA (31.5%), strB (30.8%) and blaTEM (30.0%), whereas sul2 (42.4%), tetA (42.0%), strB (34.9%), blaTEM (28.8%) and sul1 (27.8%) were most prevalent in humans. We observed no clear
Malaria infection prevalence and sensitivity of reactive case detection in Zanzibar (Publications)
residing in non-index households tested positive (OR = 8.4; 95%CI: 5.7, 12.5). Of 6,281 participants tested by quantitative polymerase chain reaction (qPCR), 8.4% of those residing in index households and 1.3% [...] households located within 50 m of the index household as compared with those located farther away (OR = 0.8, 95%CI: 0.5, 1.4). Sensitivity of RDT to detect qPCR-detectable infections was 34% (95%CI: 26.4, 42
Accuracy of urine circulating cathodic antigen (CCA) test for <em>Schistosoma mansoni</em> diagnosis in different settings of Côte d'Ivoire (Publications)
endemic for S. mansoni, whereas S. haematobium co-exists in setting C. Overall, 446 children, aged 8-12 years, submitted multiple stool and urine samples. For S. mansoni diagnosis, stool samples were examined [...] diagnostic 'gold' standard, the prevalence of S. mansoni in setting A, B and C was 32.9%, 53.1% and 91.8%, respectively. The sensitivity of triplicate Kato-Katz from the first stool and a single CCA-A test [...] 9% and 75.0%. The ether-concentration technique showed a low...
Malaria risk and access to prevention and treatment in the paddies of the Kilombero Valley, Tanzania (Publications)
35-8.51). Protection with mosquito nets in the fields was extremely good (98% usage) but home-stocking of antimalarials was uncommon. Despite the long distances to health services, 55.8% (37.9-72.8) of
Improved antiretroviral treatment outcome in a rural African setting is associated with cART initiation at higher CD4 cell counts and better general... (Publications)
mostly due to toxicity (56%), in particular polyneuropathy and anemia. Overall, 129 patients died (8.8%) and 189 (12.9%) were lost to follow-up. In a multivariate analysis, low CD4 cells at starting cART [...] 34-47), 35.4% were males, 7.6% had proven tuberculosis. Median CD4 cell count was 131 cells/mul and 24.8% had WHO stage 4. Median CD4 cell count increased by 61 and 130 cells/mul after 6 and 12 months, re
Rapid urban malaria appraisal (RUMA) III: epidemiology of urban malaria in the municipality of Yopougon (Abidjan) (Publications)
(under one year-olds), 42.8% (one to five years-olds), 42.0% (> five to 15 years-olds) and 26.8% (over 15 years-olds), while those in the control group were 13.0%. 26.7%, 21.8% and 14.6%, respectively.
