Sustaining control of schistosomiasis mansoni in western Côte d'Ivoire: results from a SCORE study, one year after initial praziquantel... (Publications)
prevalence of S. mansoni infection decreased significantly from 19.7% (95% CI: 18.5-20.8%) to 12.8% (95% CI: 11.9-13.8%), while the arithmetic mean S. mansoni eggs per gram of stool (EPG) among infected children
Efficacy and safety of a single-dose mebendazole 500 mg chewable, rapidly-disintegrating tablet for <em>Ascaris lumbricoides</em> and <em>Trichuris... (Publications)
versus 19.2% [95% CI: -5.9; 41.5]; P < 0.001) and T. trichiura (59.7% [95% CI: 33.9; 78.8] versus 10.5% [95% CI: -16.8; 32.9]; P = 0.003). Treatment-emergent adverse events (TEAEs) in MBZ group occurred in [...] significantly higher in the MBZ group than placebo for A. lumbricoides (83.7% [72/86; 95% CI: 74.2%; 90.8%] versus 11.1% [9/81; 95% CI: 5.2%; 20.1%], P < 0.001) and for T. trichiura (33.9% [42/124; 95% CI:
Explaining patient delay in healthcare seeking and loss to diagnostic follow-up among patients with presumptive tuberculosis in Tanzania: a... (Publications)
RESULTS: Among 136 interviewed patients, 86 (63.2%) were LDFU from pharmacies and TB clinic while 50 (36.8%) were non-LDFU. Out of 136 patients 88 (64.7%) delayed seeking care, of whom 59 (67%) were females [...] Among the 86 (63.2%) patients in LDFU group, 62 (72.1%) delayed seeking care, while among the 50 (36.8%) non-LDFU, 26 (52.0%) had also delayed seeking care. Prior consultation with a traditional healer (aOR [...] were all associated with patient delay. Female gender was associated with...
The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of <em>pfmdr1... (Publications)
(95% CI 10.7-15.7) for AL and 15.2 days (95% CI 12.8-18.4) for AS-AQ overall. However, the duration varied significantly between trial sites, from 8.7-18.6 days for AL and 10.2-18.7 days for AS-AQ. Significant [...] benefit to patients in higher transmission areas. METHODS: We analyzed individual patient data from 8 clinical trials of AL versus AS-AQ in 12 sites in Africa (n = 4214 individuals). The time to PCR-confirmed
Self-reported clinical history of misdiagnosed leprosy cases in the State of Mato Grosso, Brazil, 2016-2019 (Publications)
study period, 354 leprosy cases were released from treatment due to misdiagnosis, of which 162 (45.8%) could be interviewed. All interviewees expressed dissatisfaction with their treatment, which prompted [...] seek a reevaluation of their diagnosis before they were released due to "misdiagnosis". Among them, 35.8% received a final diagnosis of a musculoskeletal or connective tissue disease - mainly fibromyalgia
<em>Plasmodium vivax</em> and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea (Publications)
Evaluation Project. All presumptive malaria cases presenting at two rural health facilities over an 8-y period were investigated with history taking, clinical examination, and laboratory assessment. Case [...] (55%) had a confirmed Plasmodium parasitaemia. Among those, 6.2% (95% confidence interval [CI] 5.7%-6.8%) fulfilled the case definition of SM, most of them in children
Influence of <em>M. tuberculosis</em> lineage variability within a clinical trial for pulmonary tuberculosis (Publications)
baseline, and along with the East Asian lineage was associated with lower bacteriologic conversion after 8 weeks of treatment. Disease presentation and response to drug treatment varied by lineage, but these [...] were no longer statistically significant after adjustment for other variables associated with week-8 culture status
Carbon monoxide exposures and kitchen concentrations from cookstove-related woodsmoke in San Marcos, Peru (Publications)
measurements were 1·1 (0·9-1·2), 1·4 (1·3-1·6), and 7·3 (6·4-8·3) ppm in control households, and 1·0 (0·9-1·1), 1·4 (1·3-1·6), and 7·3 (6·4-8·2) ppm among intervention households, respectively. CONCLUSION:
Helminth parasites and hypobiosis of nematodes in N'Dama cattle during the dry season in The Gambia (Publications)
(February) to 34.8% (April) of the total nematode burden. The proportion of L4 (indicating hypobiosis) of H. contortus was 85-99%. During the dry season, 44-67% of Oesophagostomum radiatum and 8-34% of Cooperia
Transmission electron microscopic observations on ultrastructural damage in juvenile <em>Schistosoma mansoni</em> caused by artemether (Publications)
treated intragastrically with a single dose of 400 mg/kg artemether 21 days post-infection. Between 8 h and 14 days after treatment groups of two mice were sacrificed, and schistosomula recovered for t [...] tegument, subtegumental musculature, parenchymal tissues and gastrodermis. It was already apparent 8 h after drug administration and increased gradually to reach a peak, 7 days post-treatment. Tegumental
