Synthesis and <em>in vitro</em> testing of antimalarial activity of non-natural-type neocryptolepines: structure-activity relationship study of 2,11-... (Publications)
This report describes the synthesis and in vitro anti-malarial evaluations of certain C2 or C8 and C11-disubstituted 6-methyl-5H-indolo[2,3-b]quinoline (neocryptolepine congener) derivatives. To attain [...] which improved the cytotoxicity against normal cells. The best results were achieved with compounds 8 and 9d against the NF54 strain with the IC50/SI values as of 86 nM/20 and 317 nM/370, respectively.
Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach (Publications)
asthma prevalence.PM10 or NO2 higher by 10 microg.m-3 was associated with 12.8% (95% CI 9.5-16.3%) and 1.9% (95% CI 1.1-2.8%) higher lifetime asthma prevalence, respectively, independent of confounders
Self-reported clinical history of misdiagnosed leprosy cases in the State of Mato Grosso, Brazil, 2016-2019 (Publications)
study period, 354 leprosy cases were released from treatment due to misdiagnosis, of which 162 (45.8%) could be interviewed. All interviewees expressed dissatisfaction with their treatment, which prompted [...] seek a reevaluation of their diagnosis before they were released due to "misdiagnosis". Among them, 35.8% received a final diagnosis of a musculoskeletal or connective tissue disease - mainly fibromyalgia
<em>Plasmodium vivax</em> and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea (Publications)
Evaluation Project. All presumptive malaria cases presenting at two rural health facilities over an 8-y period were investigated with history taking, clinical examination, and laboratory assessment. Case [...] (55%) had a confirmed Plasmodium parasitaemia. Among those, 6.2% (95% confidence interval [CI] 5.7%-6.8%) fulfilled the case definition of SM, most of them in children
Influence of <em>M. tuberculosis</em> lineage variability within a clinical trial for pulmonary tuberculosis (Publications)
baseline, and along with the East Asian lineage was associated with lower bacteriologic conversion after 8 weeks of treatment. Disease presentation and response to drug treatment varied by lineage, but these [...] were no longer statistically significant after adjustment for other variables associated with week-8 culture status
Carbon monoxide exposures and kitchen concentrations from cookstove-related woodsmoke in San Marcos, Peru (Publications)
measurements were 1·1 (0·9-1·2), 1·4 (1·3-1·6), and 7·3 (6·4-8·3) ppm in control households, and 1·0 (0·9-1·1), 1·4 (1·3-1·6), and 7·3 (6·4-8·2) ppm among intervention households, respectively. CONCLUSION:
Helminth parasites and hypobiosis of nematodes in N'Dama cattle during the dry season in The Gambia (Publications)
(February) to 34.8% (April) of the total nematode burden. The proportion of L4 (indicating hypobiosis) of H. contortus was 85-99%. During the dry season, 44-67% of Oesophagostomum radiatum and 8-34% of Cooperia
Transmission electron microscopic observations on ultrastructural damage in juvenile <em>Schistosoma mansoni</em> caused by artemether (Publications)
treated intragastrically with a single dose of 400 mg/kg artemether 21 days post-infection. Between 8 h and 14 days after treatment groups of two mice were sacrificed, and schistosomula recovered for t [...] tegument, subtegumental musculature, parenchymal tissues and gastrodermis. It was already apparent 8 h after drug administration and increased gradually to reach a peak, 7 days post-treatment. Tegumental
Synthesis and <em>in vitro</em> testing of antimalarial activity of non-natural-type neocryptolepines: structure-activity relationship study of 2,11-... (Publications)
This report describes the synthesis and in vitro anti-malarial evaluations of certain C2 or C8 and C11-disubstituted 6-methyl-5H-indolo[2,3-b]quinoline (neocryptolepine congener) derivatives. To attain [...] which improved the cytotoxicity against normal cells. The best results were achieved with compounds 8 and 9d against the NF54 strain with the IC50/SI values as of 86 nM/20 and 317 nM/370, respectively.
Ambient air pollution, traffic noise and adult asthma prevalence: a BioSHaRE approach (Publications)
asthma prevalence.PM10 or NO2 higher by 10 microg.m-3 was associated with 12.8% (95% CI 9.5-16.3%) and 1.9% (95% CI 1.1-2.8%) higher lifetime asthma prevalence, respectively, independent of confounders
