Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling (Publications)
locations. Schistosoma haematobium, the predominant species in Nigeria, was found in 368 locations (79.8%) covering 31 states, S. mansoni in 78 (16.7%) locations in 22 states and S. intercalatum in 17 (3.7%) [...] 2% to 75% with a mean prevalence of 23% for the country as a whole (95% confidence interval (CI): 22.8-23.1%). The model suggests that the mean temperature, annual precipitation and soil acidity significantly
Evaluation of portable microscopic devices for the diagnosis of Schistosoma and soil-transmitted helminth infection (Publications)
mansoni, S. haematobium and Trichuris trichiura, the portable light microscope showed sensitivities of 84.8%, 78.6% and 81.5%, respectively, and specificities of 85.7%, 91.0% and 93.0%, respectively. For S. mansoni [...] mansoni and T. trichiura, we found sensitivities for the mobile phone microscope of 68.2% and 30.8%, respectively, and specificities of 64.3% and 71.0%, respectively. We conclude that the portable light
Absence of hepatitis delta infection in a large rural HIV cohort in Tanzania (Publications)
count was 179 cells/muL. The prevalence of anti-HDV positivity was 5.0% (95% confidence interval 2.8%-8.9%). There was no significant predictor of anti-HDV positivity. HDV could not be amplified in any
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
Genomes imputed data. We identified 10 novel loci with p-value < 5 x 10-8 previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs
Mbandakamine-type naphthylisoquinoline dimers and related alkaloids from the central African liana <em>ancistrocladus ealaensis </em>with... (Publications)
dimer mbandakamine A (3). They represent constitutionally unsymmetric dimers, each consisting of two 5,8'-coupled naphthylisoquinoline monomers. While the molecular halves of michellamine A5 (2) are linked [...] is located in one of the peri-positions, neighboring one of the outer axes. In addition, four new 5,8'-coupled monomeric naphthylisoquinolines, viz., ancistroealaines C-F (7-10), were identified, along
Quantification of viable bacterial load in artificial sputum spiked with <em>Mycobacterium tuberculosis</em> (Publications)
batches of specimens daily with high load that were stored refrigerated or at room temperature for up to 8 days. In a second series, nine different technologists processed freshly made batches of specimens with [...] deviation) of low: 271.7 (25.9), medium: 233.5 (16.3), and two batches of high load: 186.9 (12.3) and 191.8 (9.0), respectively. A variance component model that included load, storage temperature, days of storage
Effects of smoking bans on passive smoking exposure at work and at home. The European Community Respiratory Health Survey (Publications)
1998-2003 and 2.5% in 2010-14. Concurrently passive smoking at home decreased from 28.9% to 18.2% and 8.8%. When controlling for sex, age, education, smoking status and ECHRS wave, the odds of passive smoking
Semisynthetic derivatives of perovskone: development of a promising class of antiprotozoal lead compounds (Publications)
were isolated from the plant. Using perovskone (1) as a feedstock, seven semisynthetic analogues (2-8) were generated via reactions like hydroxylation, elimination, and esterification. Structural chara [...] favorable SIs of 843.0 and 80.0, comparable to those of chloroquine and artemisinin. Perovskone M (8) displayed promising antileishmanial activity (IC(50) = 0.44 μM, SI = 22), comparable to the efficacy
Body weight changes in people with HIV starting dolutegravir versus efavirenz-based regimens in a large cohort in rural Tanzania (Publications)
RESULTS: Of 1,205 PLHIV at ART start (median age 40 years (IQR 32-48); 719 (59.7%) females), 166 (13.8%) individuals were underweight and 317 (26.3%) overweight/obese; 621 (51.5%) initiated efavirenz-based [...] efavirenz group. The weight gain difference between treatment groups was high in men (1.7 kg (95%CI 0.8-2.6; p
Body weight changes in people with HIV starting dolutegravir versus efavirenz-based regimens in a large cohort in rural Tanzania (Publications)
at ART start [median age 40 years (interquartile range (IQR) 32-48); 719 (59.7%) females], 166 (13.8%) individuals were underweight and 317 (26.3%) overweight/obese; 621 (51.5%) initiated efavirenz-based [...] efavirenz group. The weight gain difference between treatment groups was high in men (1.7 kg (95% CI 0.8-2.6; P
