FLOTAC: a new sensitive technique for the diagnosis of hookworm infections in humans (Publications)
duplicate 41.7mg Kato-Katz thick smear was prepared. Next, a small portion of stool (mean weight 1.8g) was preserved in sodium acetate-acetic acid-formalin and forwarded to a European laboratory. These [...] The Kato-Katz method resulted in a significantly higher mean number of eggs per gram of stool (155.8 EPG) compared with the FLOTAC (37.7 EPG) and ether concentration (5.7 EPG) methods. The FLOTAC method
Prevalence of epilepsy in a rural district of central Lao PDR (Publications)
profile of the disease. METHODS: Door-to-door screening was performed on the entire population of 8 randomly selected villages in the Hinheub district, using an internationally validated and standardized [...] examination. Electroencephalograms were performed at the district health care center. RESULTS: In the 8 villages, 277 suspected cases of epilepsy were identified among 4,310 interviewed subjects; 194 of whom
<em>In vitro</em> and<em> in vivo</em> activity of Solithromycin (CEM-101) against <em>Plasmodium</em> species (Publications)
against the NF54 strain of P. falciparum, as well as against two multidrug-resistant strains, Dd2 and 7G8. The dramatic increase in potency observed after two generations of exposure suggests that it likely [...] Solithromycin also retained potency against azithromycin-resistant parasites derived from Dd2 and 7G8, although these lines did demonstrate a degree of cross-resistance. In an in vivo model of P. berghei
Seroprevalence survey of brucellosis among rural people in Mongolia (Publications)
y were being older than 45 years (adjusted odds ratio [AOR] = 6.9, 95% CI = 5.1-8.7) and being a veterinarian (AOR = 2.8, 95% CI = 1.5-5.0). CONCLUSION: Our study confirms that human brucellosis seroprevalence
Development of an RF-EMF exposure surrogate for epidemiologic research (Publications)
originated from near-field sources, mainly from GSM mobile phone calls (93.1%) and from DECT phone calls (4.8%). Main contributors to the whole-body dose were GSM mobile phone calls (69.0%), use of computer, laptop [...] traffic on the mobile phone via WLAN (6.5%). The exposure from mobile phone base stations contributed 1.8% to the whole-body dose, while uplink exposure from other people's mobile phones contributed 3.6%. In
Local heat application for the treatment of Buruli ulcer: results of a phase II open label single center non comparative clinical trial (Publications)
(ISRCTN 72102977) under GCP standards in Cameroon, laboratory confirmed BU patients received up to 8 weeks of heat treatment. We assessed efficacy based on the endpoints 'absence of clinical BU specific [...] lesion size was 45 cm2. Within 6 months after completion of heat treatment 92.4% (49 of 53, 95% CI 81.8% to 98.0%) achieved cure of their primary lesion. At 24 months follow-up 83.7% (41 of 49, 95% CI 70
Dioncophyllines C2, D2, and F and related naphthylisoquinoline alkaloids from the Congolese liana <em>Ancistrocladus ileboensis</em> with potent... (Publications)
Dioncophylline F (1), the first 5,8'-coupled dioncophyllaceous alkaloid (i.e., lacking an oxygen function at C-6 and possessing an R-configuration at C-3), was isolated from the recently described Congolese [...] consequence of the lack of a methyl group ortho to their biaryl axes, both dioncophylline F (1) and the 7,8'-coupled dioncophylline D2 (3) occur as pairs of configurationally semistable and, thus, slowly int
Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis (Publications)
a 10 mug.m-3 increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95%CI -25.8- -2.1) and FVC (-14.9 mL, 95% CI -28.7- -1.1). An increase of 10 mug.m-3 in PM10, but not other PM metrics [...] fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4- -3.8) and FVC (-59.0 mL, 95% CI -112.3- -5.6). The associations were particularly strong in obese persons
Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction... (Publications)
with genome-wide significant interactions. The strongest interaction was observed for rs2325934 (P=8.8x10-10). Replication of the interaction between this CDH13 variant and cumulative PM10 exposure on annual
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis (Publications)
differentiation, as well as rs2897442 in KIF3A within the cytokine cluster at 5q31.1 (OR = 1.11, P = 3.8 x 10(-8)). We also replicated association with the FLG locus and with two recently identified association
