Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study (Publications)
14% (45/317, 95% CI = 10-18%) had DF. The seroprevalence of dengue immunoglobulin G (IgG) was 83% (204/247, 95% CI = 78-87%), and no dengue hemorrhagic fever was seen. This study provides good evidence [...] Abstract. Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. We performed [...] enrolled, and 317 patients with a negative rapid diagnostic test (RDT)...
Molecular epidemiology suggests Venezuela as the origin of the dengue outbreak in Madeira, Portugal in 2012-2013 (Publications)
occurred in Madeira Island (Portugal) from October 2012 to February 2013. Published data showed that Dengue virus type 1 DENV-1) introduced from South America was the incriminated virus. We aim to determine
Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness (Publications)
The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appear associated with greater epidemic potential. The mechanisms governing viral fitness in ep
Pan-dengue virus detection by PCR for travelers returning from the tropics (Publications)
We performed dengue virus (DENV) serology and quantitative real-time pan-DENV reverse transcription-PCR (RT-PCR) on 186 sera of 171 patients returning from the tropics. DENV loads significantly decreased
Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop5 (Publications)
Travelers have the potential both to acquire and to spread dengue virus infection. The incidence of dengue fever (DF) among European travelers certainly is underestimated, because few centers use standardized [...] Disease Surveillance (TropNetEurop) to gain information on the quantity and severity of cases of dengue imported into Europe. Descriptions of 294 patients with DF were analyzed for epidemiological information [...] infections were imported from Asia, which suggests a high risk of DF...
Severe dengue virus infection in travelers: risk factors and laboratory indicators (Publications)
BACKGROUND: Dengue fever is the most common arboviral disease in travelers. In countries where dengue virus is endemic, sequential (secondary) infections with different dengue virus serotypes are associated [...] secondary infection rates in a population of travelers are lacking. METHODS: Intensified surveillance of dengue fever in travelers was performed within the European Network on Surveillance of Imported Infectious [...] collected at 14 European clinical referral centers between 2003 and...
The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation (Publications)
Newly assembled dengue viruses (DENV) undergo maturation to become infectious particles. The maturation process involves major rearrangement of virus surface premembrane (prM) and envelope (E) proteins
