Short-term effects of PM10, NO2, SO2 and O3 on cardio-respiratory mortality in Cape Town, South Africa, 2006-2015 (Publications)
increased risk of 2.4% (95% CI: 0.9–3.9%), 2.2 (95% CI: 0.4–4.1%), 1.4% (95% CI: 0–2.8%) and 2.5% (95% CI: 0.2–4.8%), respectively. For RD, only NO2 showed a significant positive association with a 4.5%
Estimating the effect of vaccination on antimicrobial-resistant typhoid fever in 73 countries supported by Gavi: a mathematical modelling study (Publications)
[PI] 0-49). TCV introduction with a catch-up campaign was predicted to avert 42.5 million (95% PI 24.8-62.8 million) cases and 506 000 (95% PI 187 000-1.9 million) deaths caused by FQNS typhoid fever, and
Association between allergic sensitization and intestinal parasite infection in schoolchildren in Gqeberha, South Africa (Publications)
communities in Gqeberha, South Africa. METHODS: In a cross-sectional study, 587 school children aged 8-12 years were recruited in June 2016 and screened for reactivity to common allergens by skin prick tests [...] (21.0%). Infections with geohelminths (Ascaris lumbricoides, Trichuris trichiura) were found in 26.8% and protozoan infections (Gardia lamblia, Cryptosporidia spp.) in 13.9% of study participants. Mixed
Short-term joint effects of PM10, NO2 and SO2 on cardio-respiratory disease hospital admissions in Cape Town, South Africa (Publications)
2–2.4%), respectively. For cardiovascular disease (CVD), these values were 2.1% (0.6–3.5%),1% (−0.8–2.8%), and−0.3% (−1.6–1.1%), respectively, per inter-quartile range increase of 12μg/m3for PM10, 7.3μg/m3for
Optimizing moxidectin dosing for <em>Strongyloides stercoralis</em> infections: insights from pharmacometric modeling (Publications)
Moxidectin is a frontrunner drug candidate in the treatment of strongyloidiasis. A dose of 8 mg is recommended to treat this indication, which shows a reasonably good efficacy and tolerability profile [...] whereas in the moderate-to-high intensity group (LPG > 1) the cure rate plateaus at ~ 87%, following an 8 mg dose. To enhance efficacy further, studies using repeated dosing based on the duration of the au
Recognition and management of clinically significant drug-drug interactions between antiretrovirals and co-medications in a cohort of people living... (Publications)
NCD was associated with an increased risk for unrecognized/incorrect DDI management (OR = 15.8; 95% CI = 1.8-139.6). CONCLUSIONS: Recognition/appropriate management of DDIs is suboptimal, highlighting the
Immunogenicity and protective efficacy of radiation-attenuated and chemo-attenuated PfSPZ vaccines in Equatoguinean adults (Publications)
immunogenicity, and VE against homologous CHMI of three doses of 2.7 x 10(6) PfSPZ of PfSPZ Vaccine at 8-week intervals and three doses of 1.0 x 10(5) PfSPZ of PfSPZ-CVac at 4-week intervals with each arm [...] recipients at time of CHMI. Vaccine efficacy at a median of 14 weeks after last PfSPZ-CVac dose was 55% (8 of 13, P = 0.051) and at a median of 15 weeks after last PfSPZ Vaccine dose was 27% (5 of 15, P = 0
Reproducibility of pacing profiles in elite swimmers (Publications)
to compare heats and finals within 1 event. METHODS: Finals and heats of 158 male swimmers (age 22.8 +/- 2.9 y) from 29 nations were analyzed in 2 competitions (downloaded from swimrankings.net). Of these [...] standard deviations between and within swimmers. RESULTS: CV for total time in finals ranged between 0.8% and 1.3% (CL 0.6-2.2%). Regarding split times, 200-m freestyle showed a consistent pacing over all
Health-related quality of life in migrant preschool children (Publications)
81.7 +/- 11.7 for children with none, one or two migrant parents, respectively; Youp'la Bouge: 83.8 +/- 8.6; 82.9 +/- 9.5; 80.7 +/- 11.7, all p < 0.05). Similar results were found in Ballabeina and Youp'la
Access to artemisinin-based anti-malarial treatment and its related factors in rural Tanzania (Publications)
demographics, seasonality, and socio economic status. RESULTS: In Kilombero-Ulanga, 41.8% (CI: 36.6--45.1) and in Rufiji 36.8% (33.7--40.1) of fever cases had access to an authorized ACT provider within 24 hours
