Unit | Clinical Research

Participant in paediatric TB diagnostic trial, Bagamoyo, Tanzania

The Clinical Research Unit (CRU) at Swiss TPH designs, conducts, and reports on clinical research studies, primarily in and for low- and middle-income countries, with a focus on vulnerable populations.

In collaboration with international partner institutions, we conduct high-quality scientific studies in the areas of tuberculosis, HIV/AIDS, febrile illnesses, neglected tropical diseases, non-communicable chronic diseases, and mental health. The goal of our work is to gain knowledge about novel clinical tools or interventions, share our findings with the scientific community and the public, inform health policy, and translate knowledge into improved health. We typically work in multidisciplinary and transdisciplinary projects in which building research capacity plays a central role. We provide teaching, training and mentoring for students and young scientists at Swiss TPH and at our partner organizations around the globe.


Brown J.A et al. Dolutegravir in real life: self-reported mental and physical health outcomes after transitioning from efavirenz- to dolutegravir-based antiretroviral therapy in a prospective cohort study in Lesotho. HIV Med. 2022(in press). DOI: 10.1111/hiv.13352

Gils T et al. Feasibility of implementing the advanced HIV disease care package as part of community-based HIV/TB activities: a mixed-methods study protocol. BMJ Open. 2022;12(2):e057291. DOI: 10.1136/bmjopen-2021-057291

Haak F et al. Predicting complicated appendicitis based on clinical findings: the role of Alvarado and appendicitis inflammatory response scores. Langenbecks Arch Surg. 2022;407(5):2051-2057. DOI: 10.1007/s00423-022-02533-5

Haak F et al. Interprofessional differences in preoperative planning—the individualist surgeon. European Surgery. 2022(in press). DOI: 10.1007/s10353-022-00761-z

Hiza H et al. CD38 expression by antigen-specific CD4 t cells is significantly restored 5 months after treatment initiation independently of sputum bacterial load at the time of tuberculosis diagnosis. Front Med. 2022;9:821776. DOI: 10.3389/fmed.2022.821776