Unit | Clinical Research

The Clinical Research Unit (CRU) at Swiss TPH designs, conducts, and reports on clinical research studies, primarily in and for low- and middle-income countries, with a focus on vulnerable populations.

In collaboration with international partner institutions, we conduct high-quality scientific studies in the areas of tuberculosis, HIV/AIDS, febrile illnesses, neglected tropical diseases, non-communicable chronic diseases, and mental health. The goal of our work is to gain knowledge about novel clinical tools or interventions, share our findings with the scientific community and the public, inform health policy, and translate knowledge into improved health. We typically work in multidisciplinary and transdisciplinary projects in which building research capacity plays a central role. We provide teaching, training and mentoring for students and young scientists at Swiss TPH and at our partner organizations around the globe.

 

Klaus Reither

Klaus Reither

PD Dr. med. et phil.

Buziashvili M et al. Analysis of tuberculosis preventive treatment cascade among people with human immunodeficiency virus in Georgia: a mixed-methods study. Open Forum Infect Dis. 2026;13(1):ofaf768. DOI: 10.1093/ofid/ofaf768

Collins J.M, Tukvadze N, Kempker R.R. Targeting tryptophan metabolism for tuberculosis biomarkers and host-directed therapy. J Infect Dis. 2026;233(2):235-243. DOI: 10.1093/infdis/jiaf510

Gerber F et al. Same-day versus rapid ART initiation in people with HIV and symptoms of tuberculosis (SaDAPT): a randomised, non-inferiority trial in Lesotho and Malawi. Lancet HIV. 2026(in press). DOI: 10.1016/s2352-3018(25)00276-0

March V.F.A et al. Within-host evolution of drug tolerance in Mycobacterium tuberculosis. JAC Antimicrob Resist. 2026;8(1):dlag007. DOI: 10.1093/jacamr/dlag007

Miotto P et al. Clinical evaluation of a commercial culture-free targeted next-generation sequencing test for diagnosis of drug-resistant tuberculosis. Microbiol Spectr. 2026;14(2):e0303525. DOI: 10.1128/spectrum.03035-25