Unit | Clinical Research

Participant in paediatric TB diagnostic trial, Bagamoyo, Tanzania

The aim of the Clinical Research Unit (CRU) is to design, conduct, analyse and report clinical research studies at Swiss TPH and partner institutions and to provide support for Swiss TPH scientists for clinical questions. The CRU has a focus on clinical trials in phase I to III.

Research

The CRU aims to strengthen high standard clinical research at Swiss TPH. The CRU conducts clinical research in the areas of malaria, febrile illnesses, tuberculosis, HIV/AIDS, neglected tropical diseases, and emerging non-communicable chronic diseases in low- and middle-income countries in collaboration with numerous partner institutes. Key CRU research areas are found under "Main CRU Activities".

Support

The members of the CRU, who have a wide range of expertise in clinical research, provide scientific support with regard to clinical and methodological aspects during the development of research proposals and protocols. The clinical support is part of the Project and Grant Unit at Swiss TPH. All proposals and protocols for clinical trials are reviewed by the CRU. Observational clinical studies may also be reviewed if desired by the investigators.

Research Clinic at IHI, Kingani, Tanzania

Brown J.A et al. Extensive drug resistance during low-level HIV viraemia while taking NNRTI-based ART supports lowering the viral load threshold for regimen switch in resource-limited settings: a pre-planned analysis from the SESOTHO trial. J Antimicrob Chemother. 2021(in press). DOI: 10.1093/jac/dkab025

Castillo-Mancilla J.R et al. Association of incomplete adherence to antiretroviral therapy with cardiovascular events and mortality in virologically suppressed persons with HIV: the Swiss HIV cohort study. Open Forum Infect Dis. 2021;8(2):ofab032. DOI: 10.1093/ofid/ofab032

Cordey S et al. Blood virosphere in febrile Tanzanian children. Emerg Microbes Infect. 2021(in press). DOI: 10.1080/22221751.2021.1925161

Hiza H et al. Case-control, diagnostic accuracy study of a non-sputum CD38-based TAM-TB test from a single milliliter of blood. BMJ. 2021(in press). DOI: 10.1101/2021.03.10.21253246

Hodel N.C et al. Comparison of two different semiquantitative urinary dipstick tests with albumin-to-creatinine ratio for screening and classification of albuminuria according to KDIGO. A diagnostic test study. Diagnostics (Basel). 2021;11(1):81. DOI: 10.3390/diagnostics11010081