Publications

Beynon F, Mhalu G, Kumar D, Cicconi S, Langet H, Levine G.A, Agarwal G, Festo C, Glass T.R, Jacob A, Kumar G, Lwambura S, Matata L, Mkopi A, Moshiro R, Schaer F, Bandi V, Bohle L.F, Emmanuel-Fabula M, Horlacher M, Horton S, Maiba J, Makawia S, Masanja N, Mjungu D, Mtebene I.E, Odek O, Oliveira V, Pantjushenko E, Reus E, Ruffo M, Sharma K, Storey H, Tyagi M, D'Acremont V, Masanja H, Awasthi S, Wyss K, TIMCI Collaborator Group. Effectiveness of introducing pulse oximetry and clinical decision support algorithms for the management of sick children in primary care in India and Tanzania on hospitalisation and mortality: the TIMCI pragmatic cluster randomised controlled trial. EClinicalMedicine. 2025;85:103306. DOI: 10.1016/j.eclinm.2025.103306

Brown J.A, Motaboli L, Lerotholi M, Kohler M, Haenggi K, Mokete M, Chakela M.G, Kao M, Kopo M, Mokebe M, Urda L, Nsakala B.L, Lukau B, Ayakaka I, Amstutz A, Ehmer J, Klicpera A, Klimkait T, Glass T, Muhairwe J, Chammartin F, Tschumi N, Labhardt N.D. Cohort profile: the Viral load Cohort North-East Lesotho (VICONEL) from 2016 to 2023 - cohort description, test volumes, predictors of viraemia and the road ahead. BMJ Open. 2025;15(2):e085404. DOI: 10.1136/bmjopen-2024-085404

Langet H, Faye P.M, Njiri F, Cicconi S, Levine G.A, Glass T.R, Kosgei R.J, Ngari K, Schaer F, Thiongane A, Tine J.A.D, Ba M, Bohle L.F, Emmanuel-Fabula M, Faye M.M, Horton S, Miheso A, Mugo M, Ngutu M, Ruffo M, Shauri J, Sougou N.M, D’Acremont V, Wyss K, Ndiaye O, Beynon F, The TIMCI Collaborator Group. Effectiveness of introducing pulse oximetry and clinical decision support algorithms for the management of sick children in primary care in Kenya and Senegal on referral and antibiotic prescription: the TIMCI quasi-experimental pre-post study. eClinicalMedicine. 2025;83:103196. DOI: 10.1016/j.eclinm.2025.103196

Mapesi H, Rohacek M, Vanobberghen F, Gupta R, Wilson H.I, Lukau B, Amstutz A, Lyimo A, Muhairwe J, Senkoro E, Byakuzana T, Nkouabi J, Mbunda G, Siru J, Tarr A, Ramapepe E, Mphunyane M, Oehri J, Nemtsova V, Yan X, Bresser M, Glass T.R, Paris D.H, Fink G, Gingo W, Labhardt N.D, Burkard T, Weisser M. Treatment strategies to control blood pressure in people with hypertension in Tanzania and Lesotho: a randomized clinical trial. JAMA Cardiol. 2025;10(4):321-333. DOI: 10.1001/jamacardio.2024.5124

Matimbwa H, Lolo S.A, Matoy L.S, Ndaki R, Ngahyoma S, Mollel H.A, Luoga E, Vanobberghen F, Vianney J.M, Idindili B, Weisser M, KIULARCO Study Group. Factors contributing to retention in care and treatment adherence among people living with HIV returning to care in South-eastern Tanzania: a qualitative study. HIV AIDS (Auckl). 2025;17:39-57. DOI: 10.2147/hiv.S492673

Moshi L.S, Okuma J, Luoga E, Kalinjuma A.V, Mollel G.J, Sigalla G, Wilson L, Dotto E, Glass T, Vanobberghen F, Weisser M, KIULARCO study group. Trends of severe HIV disease and mortality among children in rural Tanzania. HIV Med. 2025;26(5):800-812. DOI: 10.1111/hiv.70015

Nzimande N, Murphy K, Reither K, Bosman S, Ayakaka I, Glass T.R, Vanobberghen F, Jacobs B.K.M, Signorell A, Ncayiyana J. Performance of CAD4TB artificial intelligence technology in TB screening programmes among the adult population in South Africa and Lesotho. J Clin Tuberc Other Mycobact Dis. 2025;40:100540. DOI: 10.1016/j.jctube.2025.100540

Sant Fruchtman C, Neethling I, Bradshaw D, Cobos Muñoz D, Morof D, Ngobeni S, Ngwenya X, Edwards A, Glass T, Kahn K, Herbst K, Morden E, Zinyakatira N, Groenewald P. Telephonic verbal autopsies among adults in South Africa: a feasibility and acceptability pilot study. BMJ Open. 2025;15(2):e090708. DOI: 10.1136/bmjopen-2024-090708

Signorell A, van Heerden A, Ayakaka I, Jacobs B.K, Antillon M, Tediosi F, Verjans A, Brugger C, Harkare H.V, Labhardt N.D, Bosman S, Kamele M, Keitseng M, Madonsela T, Kurscheid J, Muhairwe J, Keter A.K, Murphy K, van Ginneken B, Gils T, Katende B, Gebresenbet R.F, Erhardt R.M, Zoller T, Vanobberghen F, Glass T.R, Lynen L, Reither K. Effectiveness and cost-effectiveness of community-based TB screening algorithms using computer-aided detection (CAD) technology alone compared with CAD combined with point-of-care C reactive protein testing in Lesotho and South Africa: protocol for a pair. BMJ Open. 2025;15(7):e093989. DOI: 10.1136/bmjopen-2024-093989

Weisser M, Mapesi H, Vanobberghen F, Okuma J, Eichenberger A, Wilson H.I, Paris D.H, Kalinjuma A.V, Luoga E, Wilson L, Glass T.R, Franzeck F.C, KIULARCO Study Group. Body weight changes in people with HIV starting dolutegravir versus efavirenz-based regimens in a large cohort in rural Tanzania. Aids. 2025;39(4):362-372. DOI: 10.1097/qad.0000000000004085

Beynon F, Langet H, Bohle L.F, Awasthi S, Ndiaye O, Machoki M'Imunya J, Masanja H, Horton S, Ba M, Cicconi S, Emmanuel-Fabula M, Faye P.M, Glass T.R, Keitel K, Kumar D, Kumar G, Levine G.A, Matata L, Mhalu G, Miheso A, Mjungu D, Njiri F, Reus E, Ruffo M, Schär F, Sharma K, Storey H.L, Masanja I, Wyss K, D'Acremont V, TIMCI Collaborator Group. The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms. Glob Health Action. 2024;17:2326253. DOI: 10.1080/16549716.2024.2326253

Bosman S, Ayakaka I, Muhairwe J, Kamele M, van Heerden A, Madonsela T, Labhardt N.D, Sommer G, Bremerich J, Zoller T, Murphy K, van Ginneken B, Keter A.K, Jacobs B.K.M, Bresser M, Signorell A, Glass T.R, Lynen L, Reither K. Evaluation of C-reactive protein and computer-aided analysis of chest X-rays as tuberculosis triage tests at health facilities in Lesotho and South Africa. Clin Infect Dis. 2024;79(5):1293-1302. DOI: 10.1093/cid/ciae378

Bresser M, Erhardt R.M, Shanaube K, Simwinga M, Mahlatsi P.A, Belus J, Schaap A, Amstutz A, Gachie T, Glass T.R, Kangololo B, Mota J, Floyd S, Katende B, Klinkenberg E, Ayles H, Reither K, Ruperez M. Evaluation of COVID-19 antigen rapid diagnostic tests for self-testing in Lesotho and Zambia. PLoS One. 2024;19(2):e0280105. DOI: 10.1371/journal.pone.0280105

Brown J.A, Ringera I.K, Luoga E, Bresser M, Mothobi B, Kabundi L, Ilunga M, Mokhele K, Isaac A.B, Tsoaeli N, Mbaya T, Simba B, Mayogu K, Mabula E, Cheleboi M, Molatelle M, Kimera N, Mollel G.J, Sando D, Tschumi N, Amstutz A, Thahane L, Hlasoa M.M, Kayembe B.P, Muhairwe J, Klimkait T, Glass T.R, Weisser M, Labhardt N.D. Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial. Lancet Glob Health. 2024;12(8):e1312-e1322. DOI: 10.1016/s2214-109x(24)00183-9

Gerber F, Semphere R, Lukau B, Mahlatsi P, Mtenga T, Lee T, Kohler M, Glass T.R, Amstutz A, Molatelle M, MacPherson P, Marake N.B, Nliwasa M, Ayakaka I, Burke R, Labhardt N. Same-day versus rapid ART initiation in HIV-positive individuals presenting with symptoms of tuberculosis: protocol for an open-label randomized non-inferiority trial in Lesotho and Malawi. PLoS One. 2024;19(2):e0288944. DOI: 10.1371/journal.pone.0288944

Keter A.K, Vanobberghen F, Lynen L, Van Heerden A, Fehr J, Olivier S, Wong E.B, Glass T.R, Reither K, Goetghebeur E, Jacobs B.K.M. Simultaneous alleviation of verification and reference standard biases in a community-based tuberculosis screening study using Bayesian latent class analysis. PLoS One. 2024;19(6):e0305126. DOI: 10.1371/journal.pone.0305126

Luoga E, Okuma J, Moshi L, Sigalla G, Mnzava D, Paris D.H, Glass T.R, Vanobberghen F, Weisser M, Mollel G.J, KIULARCO working group. Viral suppression and adherence in adolescents living with HIV in rural Tanzania. PLoS One. 2024;19(12):e0315866. DOI: 10.1371/journal.pone.0315866

Vanobberghen F, Keter A.K, Jacobs B.K.M, Glass T.R, Lynen L, Law I, Murphy K, van Ginneken B, Ayakaka I, van Heerden A, Maama L, Reither K. Computer-aided detection thresholds for digital chest radiography interpretation in tuberculosis diagnostic algorithms. ERJ Open Res. 2024;10. DOI: 10.1183/23120541.00508-2023

Wiesler B, Hirt L, Guenin M.O, Steinemann D.C, von Flüe M, Müller-Stich B, Glass T, von Strauss und Torney M. Stoma associated complications after diverting loop ileostomy, end ileostomy or split stoma formation after right sided colectomy: a retrospective cohort study (StoComSplit Analysis). Tech Coloproctol. 2024;28:68. DOI: 10.1007/s10151-024-02945-z

Brown J.A, Nsakala B.L, Mokhele K, Rakuoane I, Muhairwe J, Glass T.R, Amstutz A, Tschumi N, Belus J.M, Klimkait T, Labhardt N.D. Dolutegravir in real life: self-reported mental and physical health outcomes after transitioning from efavirenz- to dolutegravir-based antiretroviral therapy in a prospective cohort study in Lesotho. HIV Med. 2023;24(2):153-162. DOI: 10.1111/hiv.13352

Castillo-Mancilla J.R, Morrow M, Hunt P.W, Schnittman S.R, Phillips A.N, Baker J.V, Haberer J.E, Janeiro M.J, Aragao F, Cohen C, Musinguzi N, Brown T.T, Cavassini M, Glass T.R, Serrano-Villar S, Mawhinney S, Siedner M. Beyond undetectable: modeling the clinical benefit of improved antiretroviral adherence in persons with human immunodeficiency virus with virologic suppression. Open Forum Infect Dis. 2023;10(5):ofad230. DOI: 10.1093/ofid/ofad230

Kalinjuma A.V, Glass T.R, Masanja H, Weisser M, Msengwa A.S, Vanobberghen F, Otwombe K. Statistical methods applied for the assessment of the HIV cascade and continuum of care: a systematic scoping review. BMJ Open. 2023;13(11):e071392. DOI: 10.1136/bmjopen-2022-071392

Kalinjuma A.V, Hussey H, Mollel G.J, Letang E, Battegay M, Glass T.R, Paris D, Vanobberghen F, Weisser M, KIULARCO study group. Body mass index trends and its impact of under and overweight on outcome among PLHIV on antiretroviral treatment in rural Tanzania: a prospective cohort study. PLoS One. 2023;18(8):e0290445. DOI: 10.1371/journal.pone.0290445

Katende B, Bresser M, Kamele M, Chere L, Tlahali M, Erhardt R.M, Muhairwe J, Ayakaka I, Glass T.R, Ruhwald M, van Ginneken B, Murphy K, de Vos M, Amstutz A, Mareka M, Mooko S.M, Reither K, González Fernández L. Impact of a multi-disease integrated screening and diagnostic model for COVID-19, TB, and HIV in Lesotho. PLOS Glob Public Health. 2023;3(8):e0001488. DOI: 10.1371/journal.pgph.0001488

Kopo M, Lejone T.I, Tschumi N, Glass T.R, Kao M, Brown J.A, Seiler O, Muhairwe J, Moletsane N, Labhardt N.D, Amstutz A. Effectiveness of a peer educator-coordinated preference-based differentiated service delivery model on viral suppression among young people living with HIV in Lesotho: the PEBRA cluster-randomized trial. PLoS Med. 2023;20(1):e1004150. DOI: 10.1371/journal.pmed.1004150

Labhardt N.D, González Fernández L, Katende B, Muhairwe J, Bresser M, Amstutz A, Glass T.R, Ruhwald M, Sacks J.A, Escadafal C, Mareka M, Mooko S.M, de Vos M, Reither K. Head-to-head comparison of nasal and nasopharyngeal sampling using SARS-CoV-2 rapid antigen testing in Lesotho. PLoS One. 2023;18(3):e0278653. DOI: 10.1371/journal.pone.0278653

Mnzava D, Okuma J, Ndege R, Kimera N, Ntamatungiro A, Nyuri A, Byakuzana T, Abilahi F, Mayeka P, Temba E, Fanuel T, Glass T.R, Klimkait T, Vanobberghen F, Weisser M, KIULARCO Study Group. Decentralization of viral load testing to improve HIV care and treatment cascade in rural Tanzania: observational study from the Kilombero and Ulanga Antiretroviral Cohort. BMC Infect Dis. 2023;23:222. DOI: 10.1186/s12879-023-08155-6

Murphy K, Muhairwe J, Schalekamp S, van Ginneken B, Ayakaka I, Mashaete K, Katende B, van Heerden A, Bosman S, Madonsela T, González Fernández L, Signorell A, Bresser M, Reither K, Glass T.R. COVID-19 screening in low resource settings using artificial intelligence for chest radiographs and point-of-care blood tests. Sci Rep. 2023;13:19692. DOI: 10.1038/s41598-023-46461-w

Seiler O, Kopo M, Kao M, Lejone T.I, Tschumi N, Glass T.R, Brown J.A, Labhardt N.D, Amstutz A. HIV care preferences among young people living with HIV in Lesotho: a secondary data analysis of the PEBRA cluster randomized trial. AIDS Res Treat. 2023;2023:8124192. DOI: 10.1155/2023/8124192

Haak F, Kollmar O, Ioannidis A, Slotta J.E, Ghadimi M.B, Glass T, von Strauss und Torney M. Predicting complicated appendicitis based on clinical findings: the role of Alvarado and appendicitis inflammatory response scores. Langenbecks Arch Surg. 2022;407(5):2051-2057. DOI: 10.1007/s00423-022-02533-5

Haak F, Poletti T, Grossman N, von Holzen U, Bolli M, Klasen J.M, Glass T, von Strauss M, Torney M.D. Interprofessional differences in preoperative planning: the individualist surgeon. European Surgery. 2022;54(5):267-272. DOI: 10.1007/s10353-022-00761-z

Katende B, González Fernández L, Muhairwe J, Glass T.R, Ayakaka I, Labhardt N.D, Ruhwald M, de Vos M, Bresser M, Reither K. Diagnosis of SARS-CoV-2 infection from breath: a proof-of-concept study. IJID Reg. 2022;5:163-164. DOI: 10.1016/j.ijregi.2022.10.007

Magnolini R, Senkoro E, Kalinjuma A.V, Kitau O, Kivuma B, Samson L, Eichenberger A, Mollel G.J, Krinke E, Okuma J, Ndege R, Glass T, Mapesi H, Vanobberghen F, Battegay M, Weisser M. Stigma-directed services (Stig2Health) to improve 'linkage to care' for people living with HIV in rural Tanzania: study protocol for a nested pre-post implementation study within the Kilombero and Ulanga Antiretroviral Cohort. AAS Open Res. 2022;5:14. DOI: 10.12688/aasopenres.13353.2

Mollel G.J, Moshi L, Hazem H, Eichenberger A, Kitau O, Mapesi H, Glass T.R, Paris D.H, Weisser M, Vanobberghen F. Causes of death and associated factors over a decade of follow-up in a cohort of people living with HIV in rural Tanzania. BMC Infect Dis. 2022;22:37. DOI: 10.1186/s12879-021-06962-3

Muhairwe J.A, Brown J.A, Motaboli L, Nsakala B.L, Lerotholi M, Amstutz A, Klimkait T, Glass T.R, Labhardt N.D. The suboptimal pediatric HIV viral load cascade: multidistrict cohort study among children taking antiretroviral therapy in Lesotho, Southern Africa. Pediatr Infect Dis J. 2022;41(3):e75-e80. DOI: 10.1097/INF.0000000000003415

Ndege R.C, Okuma J, Kalinjuma A.V, Mkumbo J, Senkoro E, Fue G, Samson L, Mapesi H, Shabani S, Glass T.R, Battegay M, Paris D.H, Vanobberghen F, Weisser M, KIULARCO Study Group. Failure to return pillbox is a predictor of being lost to follow-up among people living with HIV on antiretroviral therapy in rural Tanzania. HIV Med. 2022;23(6):661-672. DOI: 10.1111/hiv.13223

Willburger J.C.F, von Strauss M, Peterson C.J, Glass T.R, Kettelhack C. Incidence, treatment and outcome of patients with retroperitoneal soft-tissue sarcoma in Switzerland 2005-2015: a population-based analysis. World J Surg. 2022;46(2):461-468. DOI: 10.1007/s00268-021-06374-z

Amstutz A, Lejone T.I, Khesa L, Kopo M, Kao M, Muhairwe J, Bresser M, Räber F, Klimkait T, Battegay M, Glass T.R, Labhardt N.D. Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: the VIBRA cluster-randomized clinical trial. PLoS Med. 2021;18(10):e1003839. DOI: 10.1371/journal.pmed.1003839

Amstutz A, Matsela L, Lejone T.I, Kopo M, Glass T.R, Labhardt N.D. Reaching absent and refusing individuals during home-based HIV testing through self-testing-at what cost?. Front Med. 2021;8:653677. DOI: 10.3389/fmed.2021.653677

Castillo-Mancilla J.R, Cavassini M, Schneider M.P, Furrer H, Calmy A, Battegay M, Scanferla G, Bernasconi E, Gunthard H.F, Glass T.R, Swiss HIV Cohort Study. Association of incomplete adherence to antiretroviral therapy with cardiovascular events and mortality in virologically suppressed persons with HIV: the Swiss HIV cohort study. Open Forum Infect Dis. 2021;8(2):ofab032. DOI: 10.1093/ofid/ofab032