Thommen B.T, Passecker A, Buser T, Hitz E, Voss T.S, Brancucci N.M.B. Revisiting the effect of pharmaceuticals on transmission stage formation in the malaria parasite Plasmodium falciparum. Front Cell Infect Microbiol. 2022;12:802341. DOI: 10.3389/fcimb.2022.802341

2022
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Boltryk S.D, Passecker A, Alder A, Carrington E, van de Vegte-Bolmer M, van Gemert G.J, van der Starre A, Beck H.P, Sauerwein R.W, Kooij T.W.A, Brancucci N.M.B, Proellochs N.I, Gilberger T.W, Voss T.S. CRISPR/Cas9-engineered inducible gametocyte producer lines as a valuable tool for Plasmodium falciparum malaria transmission research. Nat Commun. 2021;12:4806. DOI: 10.1038/s41467-021-24954-4

2021
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Bui H.T.N, Passecker A, Brancucci N.M.B, Voss T.S. Investigation of heterochromatin protein 1 function in the malaria parasite Plasmodium falciparum using a conditional domain deletion and swapping approach. mSphere. 2021;6(1):e01220-20. DOI: 10.1128/mSphere.01220-20

2021
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Hitz E, Grüninger O, Passecker A, Wyss M, Scheurer C, Wittlin S, Beck H.P, Brancucci N.M.B, Voss T.S. The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis. Commun Biol. 2021;4(1):336. DOI: 10.1038/s42003-021-01873-0

2021
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Hitz E, Wiedemar N, Passecker A, Graça B.A.S, Scheurer C, Wittlin S, Brancucci N.M.B, Vakonakis I, Mäser P, Voss T.S. The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites. PLoS Biol. 2021;19(12):e3001483. DOI: 10.1371/journal.pbio.3001483

2021
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Brancucci N.M.B, Heussler V.T, Gruring C. Targeting Plasmodium plasmepsin V: hitting two birds with one stone. Trends Parasitol. 2020;36(2):85-87. DOI: 10.1016/j.pt.2019.12.006

2020
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De Niz M, Kehrer J, Brancucci N.M.B, Moalli F, Reynaud E.G, Stein J.V, Frischknecht F. 3D imaging of undissected optically cleared Anopheles stephensi mosquitoes and midguts infected with Plasmodium parasites. PLoS One. 2020;15(9):e0238134. DOI: 10.1371/journal.pone.0238134

2020
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Alam M.M, Sanchez-Azqueta A, Janha O, Flannery E.L, Mahindra A, Mapesa K, Char A.B, Sriranganadane D, Brancucci N.M.B, Antonova-Koch Y, Crouch K, Simwela N.V, Millar S.B, Akinwale J, Mitcheson D, Solyakov L, Dudek K, Jones C, Zapatero C, Doerig C, Nwakanma D.C, Vazquez M.J, Colmenarejo G, Lafuente-Monasterio M.J, Leon M.L, Godoi P.H.C, Elkins J.M, Waters A.P, Jamieson A.G, Alvaro E.F, Ranford-Cartwright L.C, Marti M, Winzeler E.A, Gamo F.J, Tobin A.B. Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target. Science. 2019;365(6456):eaau1682. DOI: 10.1126/science.aau1682

2019
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Bui H.T.N, Niederwieser I, Bird M.J, Dai W, Brancucci N.M.B, Moes S, Jenoe P, Lucet I.S, Doerig C, Voss T.S. Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum. Sci Rep. 2019;9:16720. DOI: 10.1038/s41598-019-53325-9

2019
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De Niz M, Meehan G.R, Brancucci N.M.B, Marti M, Rotureau B, Figueiredo L.M, Frischknecht F. Intravital imaging of host-parasite interactions in skin and adipose tissues. Cell Microbiol. 2019;21(5):e13023. DOI: 10.1111/cmi.13023

2019
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Brancucci N.M.B, De Niz M, Straub T.J, Ravel D, Sollelis L, Birren B.W, Voss T.S, Neafsey D.E, Marti M. Probing Plasmodium falciparum sexual commitment at the single-cell level. Wellcome Open Res. 2018;3:70. DOI: 10.12688/wellcomeopenres.14645.3

2018
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De Niz M, Meibalan E, Mejia P, Ma S, Brancucci N.M.B, Agop-Nersesian C, Mandt R, Ngotho P, Hughes K.R, Waters A.P, Huttenhower C, Mitchell J.R, Martinelli R, Frischknecht F, Seydel K.B, Taylor T, Milner D, Heussler V.T, Marti M. Plasmodium gametocytes display homing and vascular transmigration in the host bone marrow. Sci Adv. 2018;4(5):eaat3775. DOI: 10.1126/sciadv.aat3775

2018
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Filarsky M, Fraschka S.A, Niederwieser I, Brancucci N.M.B, Carrington E, Carrió E, Moes S, Jenoe P, Bartfai R, Voss T.S. GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing. Science. 2018;359(6381):1259-1263. DOI: 10.1126/science.aan6042

2018
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Fraschka S.A, Filarsky M, Hoo R, Niederwieser I, Yan Yam X, Brancucci N.M.B, Mohring F, Mushunje A.T, Huang X, Christensen P.R, Nosten F, Bozdech Z, Russell B, Moon R.W, Marti M, Preiser P.R, Bártfai R, Voss T.S. Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites. Cell Host Microbe. 2018;23(3):407-420 e8. DOI: 10.1016/j.chom.2018.01.008

2018
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Ross A, Brancucci N.M. On a mission to block transmission. Elife. 2018;7:e35246. DOI: 10.7554/eLife.35246

2018
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Brancucci N.M.B, Gerdt J.P, Wang C, De Niz M, Philip N, Adapa S.R, Zhang M, Hitz E, Niederwieser I, Boltryk S.D, Laffitte M.C, Clark M.A, Gruring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth D.F, Gendaszewska-Darmach E, Duraisingh M.T, Adams J.H, Voss T.S, Waters A.P, Jiang R.H.Y, Clardy J, Marti M. Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum. Cell. 2017;171(7):1532-1544 e15. DOI: 10.1016/j.cell.2017.10.020

2017
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Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci N.M, Bittker J.A, Corey V, Clarke D, Derbyshire E.R, Dornan G.L, Duffy S, Eckley S, Itoe M.A, Koolen K.M, Lewis T.A, Lui P.S, Lukens A.K, Lund E, March S, Meibalan E, Meier B.C, McPhail J.A, Mitasev B, Moss E.L, Sayes M, Van Gessel Y, Wawer M.J, Yoshinaga T, Zeeman A.M, Avery V.M, Bhatia S.N, Burke J.E, Catteruccia F, Clardy J.C, Clemons P.A, Dechering K.J, Duvall J.R, Foley M.A, Gusovsky F, Kocken C.H, Marti M, Morningstar M.L, Munoz B, Neafsey D.E, Sharma A, Winzeler E.A, Wirth D.F, Scherer C.A, Schreiber S.L. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016;538(7625):344-349. DOI: 10.1038/nature19804

2016
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Mantel P.Y, Hjelmqvist D, Walch M, Kharoubi-Hess S, Nilsson S, Ravel D, Ribeiro M, Gruring C, Ma S, Padmanabhan P, Trachtenberg A, Ankarklev J, Brancucci N.M, Huttenhower C, Duraisingh M.T, Ghiran I, Kuo W.P, Filgueira L, Martinelli R, Marti M. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria. Nat Commun. 2016;7:12727. DOI: 10.1038/ncomms12727

2016
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Brancucci N.M, Goldowitz I, Buchholz K, Werling K, Marti M. An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development. Nat Protoc. 2015;10(8):1131-42. DOI: 10.1038/nprot.2015.072

2015
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Dantzler K.W, Ravel D.B, Brancucci N.M, Marti M. Ensuring transmission through dynamic host environments: host-pathogen interactions in Plasmodium sexual development. Curr Opin Microbiol. 2015;26:17-23. DOI: 10.1016/j.mib.2015.03.005

2015
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Pelle K.G, Oh K, Buchholz K, Narasimhan V, Joice R, Milner D.A, Brancucci N.M, Ma S, Voss T.S, Ketman K, Seydel K.B, Taylor T.E, Barteneva N.S, Huttenhower C, Marti M. Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection. Genome Med. 2015;7:19. DOI: 10.1186/s13073-015-0133-7

2015
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Ankarklev J, Brancucci N.M, Goldowitz I, Mantel P.Y, Marti M. Sex: how malaria parasites get turned on. Curr Biol. 2014;24(9):R368-70. DOI: 10.1016/j.cub.2014.03.046

2014
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Brancucci N.M, Bertschi N.L, Zhu L, Niederwieser I, Chin W.H, Wampfler R, Freymond C, Rottmann M, Felger I, Bozdech Z, Voss T.S. Heterochromatin protein 1 secures survival and transmission of malaria parasites. Cell Host Microbe. 2014;16(2):165-176. DOI: 10.1016/j.chom.2014.07.004

2014
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Brancucci N.M, Witmer K, Schmid C, Voss T.S. A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum. PLoS One. 2014;9(6):e100183. DOI: 10.1371/journal.pone.0100183

2014
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Brancucci N.M.B. Novel insights into the epigenetic regulation of Plasmodium falciparum virulence genes. Basel: Univ. Basel, 2013. PhD Thesis, University of Basel, Faculty of Science DOI: 10.5451/unibas-006218045

2013
Thesis

Brancucci N.M, Witmer K, Schmid C.D, Flueck C, Voss T.S. Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum. Cell Microbiol. 2012;14(12):1836-1848. DOI: 10.1111/cmi.12004

2012
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Oehring S.C, Woodcroft B.J, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Mäser P, Flück C, Witmer K, Brancucci N.M, Niederwieser I, Jenoe P, Ralph S.A, Voss T.S. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome Biol. 2012;13(11):R108. DOI: 10.1186/gb-2012-13-11-r108

2012
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Witmer K, Schmid C.D, Brancucci N.M, Luah Y.H, Preiser P.R, Bozdech Z, Voss T.S. Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling. Mol Microbiol. 2012;84(2):243-259. DOI: 10.1111/j.1365-2958.2012.08019.x

2012
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