Publications
Baert L, Rudy S, Pellisson M, Doll T, Rocchetti R, Kaiser M, Mäser P, Müller M. Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani. PLoS Negl Trop Dis. 2024;18(1):e001155. DOI: 10.1371/journal.pntd.0011559
Duwor S, Brites D, Mäser P. Phylogenetic analysis of pyruvate-ferredoxin oxidoreductase, a redox enzyme involved in the pharmacological activation of nitro-based prodrugs in bacteria and protozoa. Biology (Basel). 2024;13(3):178. DOI: 10.3390/biology13030178
Hamid A, Mäser P, Mahmoud A.B. Drug repurposing in the chemotherapy of infectious diseases. Molecules. 2024;29(3):635. DOI: 10.3390/molecules29030635
Seebacher W, Hoffelner M, Belaj F, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Tetrahydropyridinylidene ammonium salts with arylalkyl and diarylalkyl substitution and their antiprotozoal activity. Monatsh Chem. 2024;155:73-81. DOI: 10.1007/s00706-023-03142-8
Journal Article
Walesch S, Garcia R, Mahmoud A.B, Panter F, Bollenbach S, Mäser P, Kaiser M, Krug D, Müller R. New myxobacteria of the Myxococcaceae clade produce angiolams with antiparasitic activities. Microbiol Spectr. 2024;12(3):e0368923. DOI: 10.1128/spectrum.03689-23
Albisetti A, Hälg S, Zoltner M, Mäser P, Wiedemar N. Suramin action in African trypanosomes involves a RuvB-like DNA helicase. Int J Parasitol Drugs Drug Resist. 2023;23:44-53. DOI: 10.1016/j.ijpddr.2023.09.003
Burri C, Mäser P, Chappuis F. Human African trypanosomiasis. In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 623-635. Amsterdam: Elsevier, 2023. DOI: 10.1016/B978-0-7020-7959-7.00051-8
Book Section
Fesser A, Beilstein S, Kaiser M, Schmidt R.S, Mäser P. Trypanosoma cruzi STIB980: a TcI strain for drug discovery and reverse genetics. Pathogens. 2023;12(10):1217. DOI: 10.3390/pathogens12101217
Hinteregger C, Dolensky J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids. Molecules. 2023;28:307. DOI: 10.3390/molecules28010307
Hochegger P, Hermann T, Dolensky J, Seebacher W, Saf R, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Weis R. Structure-activity relationships and antiplasmodial potencies of novel 3,4-disubstituted 1,2,5-oxadiazoles. Int J Mol Sci. 2023;24(19):14480. DOI: 10.3390/ijms241914480
Mäser P, Bernhard S, Brun R, Burri C, Gagneux S, Hetzel M.W, Kaiser M, Lengeler C, Pluschke G, Reus E, Rottmann M, Utzinger J, Warryn L, Wittlin S, Keiser J. Key contributions by the Swiss Tropical and Public Health Institute towards new and better drugs for tropical diseases. Chimia (Aarau). 2023;77(9):593-606. DOI: 10.2533/chimia.2023.593
Meier L, Antillón M, Burri C, Chitnis N, Endriss Y, Keiser J, Moore S, Müller P, Penny M, Voss T.S, Mäser P, Utzinger J. Repurposing know-how for drug development: case studies from the Swiss Tropical and Public Health Institute. Chimia (Aarau). 2023;77(9):582-592. DOI: 10.2533/chimia.2023.582
Rao S.P.S, Gould M.K, Noeske J, Saldivia M, Jumani R.S, Ng P.S, Rene O, Chen Y.L, Kaiser M, Ritchie R, Francisco A.F, Johnson N, Patra D, Cheung H, Deniston C, Schenk A.D, Cortopassi W.A, Schmidt R.S, Wiedemar N, Thomas B, Palkar R, Ghafar N.A, Manoharan V, Luu C, Gable J.E, Wan K.F, Myburgh E, Mottram J.C, Barnes W, Walker J, Wartchow C, Aziz N, Osborne C, Wagner J, Sarko C, Kelly J.M, Manjunatha U.H, Mäser P, Jiricek J, Lakshminarayana S.B, Barrett M.P, Diagana T.T. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science. 2023;380(6652):1349-1356. DOI: 10.1126/science.adh0614
Seebacher W, Kaiser M, Mäser P, Saf R, Pferschy-Wenzig E.M, Weis R. Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity. Monatsh Chem. 2023;154:105-114. DOI: 10.1007/s00706-022-03003-w
Journal Article
Sevik Kilicaslan O, Cretton S, Hausmann E, Quirós-Guerrero L, Karimou S, Kaiser M, Mäser P, Christen P, Cuendet M. Antiprotozoal activity of natural products from Nigerien plants used in folk medicine. Front Pharmacol. 2023;14:1190241. DOI: 10.3389/fphar.2023.1190241
Utzinger J, Mäser P. Swiss TPH: 30 years of R&D towards new drugs for tropical diseases. Chimia (Aarau). 2023;77(9):570-571. DOI: 10.2533/chimia.2023.570
Utzinger J,Mäser P, eds. Swiss TPH: 30 years of R&D towards new drugs for tropical diseases. 77. Special issue, 2023. DOI: 10.2533/chimia.2023.570
Edited Book
Walz A, Duffey M, Aljayyoussi G, Sax S, Leroy D, Besson A, Burrows J.N, Cherkaoui-Rbati M.H, Gobeau N, Westwood M-A, Siethoff C, Gamo S, Mäser P, Wittlin S. The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of Plasmodium falciparum viability after antimalarial treatment in vitro. Pharmaceuticals (Basel). 2023;16(2):163. DOI: 10.3390/ph16020163
Beilstein S, El Phil R, Sahraoui S.S, Scapozza L, Kaiser M, Mäser P. Laboratory selection of trypanosomatid pathogens for drug resistance. Pharmaceuticals (Basel). 2022;15(2):135. DOI: 10.3390/ph15020135
Bernhard S, Kaiser M, Burri C, Mäser P. Fexinidazole for human African trypanosomiasis, the fruit of a successful public-private partnership. Diseases. 2022;10(4):90. DOI: 10.3390/diseases10040090
Dolensky J, Hinteregger C, Leitner A, Seebacher W, Saf R, Belaj F, Mäser P, Kaiser M, Weis R. Antiprotozoal activity of azabicyclo-nonanes linked to tetrazole or sulfonamide cores. Molecules. 2022;27(19):6217. DOI: 10.3390/molecules27196217
Hermann T, Wallner R, Dolensky J, Seebacher W, Pferschy-Wenzig E.-M, Kaiser M, Mäser P, Weis R. New derivatives of the multi-stage active Malaria Box compound MMV030666 and their antiplasmodial potencies. Pharmaceuticals (Basel). 2022;15(12):1503. DOI: 10.3390/ph15121503
Journal Article
Koester D.C, Marx V.M, Williams S, Jiricek J, Dauphinais M, René O, Miller S.L, Zhang L, Patra D, Chen Y.L, Cheung H, Gable J, Lakshminarayana S.B, Osborne C, Galarneau J.R, Kulkarni U, Richmond W, Bretz A, Xiao L, Supek F, Wiesmann C, Honnappa S, Be C, Mäser P, Kaiser M, Ritchie R, Barrett M.P, Diagana T.T, Sarko C, Rao S.P.S. Discovery of novel quinoline-based proteasome inhibitors for human African trypanosomiasis (HAT). J Med Chem. 2022;65:11776−11787. DOI: 10.1021/acs.jmedchem.2c00791
Mäser P. Filariae as organisms. In: Kaminsky R,Geary T,Selter P, eds. Human and animal filariases: landscape, challenges, and control, 17-32: Wiley, 2022
Book Section
Mousavi A, Foroumadi P, Emamgholipour Z, Mäser P, Kaiser M, Foroumadi A. 2-(Nitroaryl)-5-substituted-1,3,4-thiadiazole derivatives with antiprotozoal activities: in vitro and in vivo study. Molecules. 2022;27:5559. DOI: 10.3390/molecules27175559
Scheiber N, Blaser G, Pferschy-Wenzig E.M, Kaiser M, Mäser P, Presser A. Efficient oxidative dearomatisations of substituted phenols using hypervalent iodine (iii) reagents and antiprotozoal evaluation of the resulting cyclohexadienones against T. b. rhodesiense and P. falciparum strain NF54. Molecules. 2022;27(19):6559. DOI: 10.3390/molecules27196559
Sevik Kilicaslan O, Cretton S, Quiros-Guerrero L, Bella M.A, Kaiser M, Mäser P, Ndongo J.T, Cuendet M. Isolation and structural elucidation of compounds from Pleiocarpa bicarpellata and their in vitro antiprotozoal activity. Molecules. 2022;27(7):2200. DOI: 10.3390/molecules27072200
Barth-Jaeggi T, Mäser P. Leishmaniasis in Europe and Central Asia: epidemiology, impact of habitat and lifestyle changes, HIV coinfection. In: Steinmann P,Utzinger J, eds. Neglected tropical diseases - Europe and Central Asia, 83-100. Cham: Springer, 2021. DOI: 10.1007/978-3-030-84224-6_5
Book Section
Boberg M, Cal M, Kaiser M, Jansson-Lofmark R, Mäser P, Ashton M. Enantiospecific antitrypanosomal in vitro activity of eflornithine. PLoS Negl Trop Dis. 2021;15(7):e0009583. DOI: 10.1371/journal.pntd.0009583
Brand M, Wang L, Agnello S, Gazzola S, Gall F.M, Raguz L, Kaiser M, Schmidt R.S, Ritschl A, Jelk J, Hemphill A, Mäser P, Butikofer P, Adams M, Riedl R. Antiprotozoal structure-activity relationships of synthetic leucinostatin derivatives and elucidation of their mode of action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621. DOI: 10.1002/anie.202102153
Cretton S, Genta-Jouve G, Kaiser M, Mäser P, Muñoz O, Bürgi T, Cuendet M, Christen P. Hygroline derivatives from Schizanthus tricolor and their anti-trypanosomatid and antiplasmodial activities. Phytochemistry. 2021;192:112957. DOI: 10.1016/j.phytochem.2021.112957
Fesser A, Kaiser M, Mäser P. Neue Parameter für die Wirkstofftestung gegen Trypanosoma cruzi. Biospektrum (Heidelb). 2021;27(2):168-170. DOI: 10.1007/s12268-021-1554-z
Flittner D, Kaiser M, Mäser P, Lopes N.P, Schmidt T.J. The alkaloid-enriched fraction of Pachysandra terminalis (Buxaceae) shows prominent activity against Trypanosoma brucei rhodesiense. Molecules. 2021;26(3):591. DOI: 10.3390/molecules26030591
Greve H.L, Kaiser M, Mäser P, Schmidt T.J. Boswellic acids show in vitro activity against Leishmania donovani. Molecules. 2021;26(12):3651. DOI: 10.3390/molecules26123651
Hermann T, Hochegger P, Dolensky J, Seebacher W, Pferschy-Wenzig E.M, Saf R, Kaiser M, Mäser P, Weis R. Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity. Pharmaceuticals (Basel). 2021;14:1109. DOI: 10.3390/ph14111109
Hermann T, Hochegger P, Dolensky J, Seebacher W, Saf R, Kaiser M, Mäser P, Weis R. New acyl derivatives of 3-aminofurazanes and their antiplasmodial activities. Pharmaceuticals (Basel). 2021;14(5):412. DOI: 10.3390/ph14050412
Hitz E, Wiedemar N, Passecker A, Graça B.A.S, Scheurer C, Wittlin S, Brancucci N.M.B, Vakonakis I, Mäser P, Voss T.S. The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites. PLoS Biol. 2021;19(12):e3001483. DOI: 10.1371/journal.pbio.3001483
Hochegger P, Dolensky J, Seebacher W, Saf R, Kaiser M, Mäser P, Weis R. 8-amino-6-methoxyquinoline-tetrazole hybrids: Impact of linkers on antiplasmodial activity. Molecules. 2021;26(18):5530. DOI: 10.3390/molecules26185530
Hoffelner M.H, Seebacher W, Kaiser M, Mäser P, Pferschy-Wenzig E.M, Saf R, Belaj F, Kretschmer N, Alajlani M, Brantner A, Bauer R, Weis R. Unexpected ring‑opening of 2,3‑dihydropyridines. Monatsh Chem. 2021;152:1347–1359. DOI: 10.1007/s00706-021-02847-y
Journal Article
Llurba Montesino N, Kaiser M, Mäser P, Schmidt T.J. Nucleic acid amplification techniques for the detection of Schistosoma mansoni infection in humans and the intermediate snail host: a structured review and meta-analysis of diagnostic accuracy. Molecules. 2021;26(11):3226. DOI: 10.3390/molecules26113226