Publications

Lambiris M.J, Venga G.N, Ssempala R, Balogun V, Galactionova K, Musiitwa M, Kagwire F, Olosunde O, Emedo E, Luketa S, Sangare M, Buj V, Delvento G, Tshefu A, Okitawutshu J, Omoluabi E, Awor P, Signorell A, Hetzel M.W, Lee T.T, Brunner N.C, Cereghetti N, Visser T, Napier H.G, Burri C, Lengeler C. Health system readiness and the implementation of rectal artesunate for severe malaria in sub-Saharan Africa: an analysis of real-world costs and constraints. Lancet Glob Health. 2023;11(2):e256-e264. DOI: 10.1016/S2214-109X(22)00507-1

Signorell A, Awor P, Okitawutshu J, Tshefu A, Omoluabi E, Hetzel M.W, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T.T, Brunner N.C, Lambiris M.J, Okuma J, Cereghetti N, Buj V, Visser T, Napier H.G, Lengeler C, Burri C. Health worker compliance with severe malaria treatment guidelines in the context of implementing pre-referral rectal artesunate in the Democratic Republic of the Congo, Nigeria, and Uganda: an operational study. PLoS Med. 2023;20(2):e1004189. DOI: 10.1371/journal.pmed.1004189

Awor P, Kimera J, Athieno P, Tumukunde G, Okitawutshu J, Tshefu A, Omoluabi E, Signorell A, Brunner N, Kalenga J.C, Akano B, Ayodeji K, Okon C, Yusuf O, Delvento G, Lee T, Burri C, Lengeler C, Hetzel M.W. Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic Republic of the Congo, Nigeria and Uganda. Malar J. 2022;21:322. DOI: 10.1186/s12936-022-04348-7

Awor P, Kimera J, Brunner N.C, Athieno P, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T, Amutuhaire M, Opigo J, Kaggwa F.M, Kagwire F, Nakiganda J, Burri C, Lengeler C, Hetzel M.W. Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household surveys (2018-2020). Am J Trop Med Hyg. 2022;107(4):934–938. DOI: 10.4269/ajtmh.21-1132

Brunner N.C, Omoluabi E, Awor P, Okitawutshu J, Tshefu Kitoto A, Signorell A, Akano B, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Kalenga J.C, Delvento G, Lee T.T, Lambiris M.J, Ross A, Cereghetti N, Visser T, Napier H.G, Buj V, Burri C, Lengeler C, Hetzel M.W. Prereferral rectal artesunate and referral completion among children with suspected severe malaria in the Democratic Republic of the Congo, Nigeria and Uganda. BMJ Glob Health. 2022;7(5):e008346. DOI: 10.1136/bmjgh-2021-008346

Cleary E, Hetzel M.W, Clements A.C.A. A review of malaria epidemiology and control in Papua New Guinea 1900 to 2021: progress made and future directions. Front Epidemiol. 2022;2:980795. DOI: 10.3389/fepid.2022.980795

Das A.M, Hetzel M.W, Yukich J.O, Stuck L, Fakih B.S, Al-mafazy A.-M, Ali A, Chitnis N. The impact of reactive case detection on malaria transmission in Zanzibar in the presence of human mobility. Epidemics. 2022;41:100639. DOI: 10.1016/j.epidem.2022.100639

Giduthuri J.G, Kualawi M, Muri M, Are C, Goi P, Minn Oo M, Hetzel M.W, Pomat W. Papua New Guinea national health facility survey 2021: availability and quality of malaria case management. Goroka: Papua New Guinea Institute of Medical Research, 2022

Hetzel M.W, Awor P, Tshefu A, Omoluabi E, Burri C, Signorell A, Lambiris M.J, Visser T, Cohen J.M, Buj V, Lengeler C. Pre-referral rectal artesunate: no cure for unhealthy systems. Lancet Infect Dis. 2022(in press). DOI: 10.1016/S1473-3099(22)00762-9

Hetzel M.W, Okitawutshu J, Tshefu A, Omoluabi E, Awor P, Signorell A, Brunner N.C, Kalenga J.C, Akano B.K, Ayodeji K, Okon C, Yusuf O, Athieno P, Kimera J, Tumukunde G, Angiro I, Delvento G, Lee T.T, Lambiris M.J, Kwiatkowski M, Cereghetti N, Visser T, Napier H.G, Cohen J.M, Buj V, Burri C, Lengeler C. Effectiveness of rectal artesunate as pre-referral treatment for severe malaria in children under 5 years of age: a multi-country observational study. BMC Med. 2022;20:343. DOI: 10.1186/s12916-022-02541-8

Keven J.B, Katusele M, Vinit R, Rodríguez-Rodríguez D, Hetzel M.W, Robinson L.J, Laman M, Karl S, Walker E.D. Vector composition, abundance, biting patterns and malaria transmission intensity in Madang, Papua New Guinea: assessment after 7 years of an LLIN-based malaria control programme. Malar J. 2022;21:7. DOI: 10.1186/s12936-021-04030-4

Lengeler C, Burri C, Awor P, Athieno P, Kimera J, Tumukunde G, Angiro I, Tshefu A, Okitawutshu J, Kalenga J.-C, Omoluabi E, Akano B, Ayodeji K, Okon C, Yusuf O, Brunner N.C, Delvento G, Lee T, Lambiris M.J, Visser T, Napier H.G, Cohen J.M, Buj V, Signorell A, Hetzel Manuel W, Caramal Consortium. Community access to rectal artesunate for malaria (CARAMAL): a large-scale observational implementation study in the Democratic Republic of the Congo, Nigeria and Uganda. PLoS Glob Public Health. 2022;2(9):e0000464. DOI: 10.1371/journal.pgph.0000464

Namango I.H, Marshall C, Saddler A, Ross A, Kaftan D, Tenywa F, Makungwa N, Odufuwa O.G, Ligema G, Ngonyani H, Matanila I, Bharmal J, Moore J, Moore S.J, Hetzel M.W. The Centres for Disease Control light trap (CDC-LT) and the human decoy trap (HDT) compared to the human landing catch (HLC) for measuring Anopheles biting in rural Tanzania. Malar J. 2022;21:181. DOI: 10.1186/s12936-022-04192-9

Naung M.T, Martin E, Munro J, Mehra S, Guy A.J, Laman M, Harrison G.L.A, Tavul L, Hetzel M, Kwiatkowski D, Mueller I, Bahlo M, Barry A.E. Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens. PLoS Comput Biol. 2022;18(2):e1009801. DOI: 10.1371/journal.pcbi.1009801

Okitawutshu J, Signorell A, Kalenga J.C, Mukomena E, Delvento G, Burri C, Mwaluke F, Buj V, Sangare M, Luketa S, Brunner N, Lee T, Hetzel M, Lengeler C, Tshefu A. Key factors predicting suspected severe malaria case management and health outcomes: an operational study in the Democratic Republic of the Congo. Malar J. 2022;21:274. DOI: 10.1186/s12936-022-04296-2

Seidahmed O, Jamea S, Kurumop S, Timbi D, Makita L, Ahmed M, Freeman T, Pomat W, Hetzel M.W. Stratification of malaria incidence in Papua New Guinea (2011–2019): contribution towards a sub-national control policy. PLoS Glob Public Health. 2022;2(11):e0000747. DOI: 10.1371/journal.pgph.0000747

Vera-Arias C.A, Holzschuh A, Oduma C.O, Badu K, Abdul-Hakim M, Yukich J, Hetzel M.W, Fakih B.S, Ali A, Ferreira M.U, Ladeia-Andrade S, Sáenz F.E, Afrane Y, Zemene E, Yewhalaw D, Kazura J.W, Yan G, Koepfli C. High-throughput Plasmodium falciparum hrp2 and hrp3 gene deletion typing by digital PCR to monitor malaria rapid diagnostic test efficacy. Elife. 2022;11:e72083. DOI: 10.7554/eLife.72083

Awor P, Khim N, Coppée R, Rondepierre L, Roesch C, Khean C, Kul C, Eam R, Lorn T, Athieno P, Kimera J, Clain J, Ringwald P, Signorell A, Lengeler C, Burri C, Ariey F, Hetzel M.W, Witkowski B. Clonal expansion of artemisinin-resistant Plasmodium falciparum in Uganda is associated with substandard treatment practices. Lancet. 2021(in press). DOI: 10.2139/ssrn.3974542

Brunner N.C, Awor P, Hetzel M.W. Definitions of severity in treatment seeking studies of febrile illness in children in low and middle income countries: a scoping review. Int J Public Health. 2021;66:634000. DOI: 10.3389/ijph.2021.634000

Brunner N.C, Karim A, Athieno P, Kimera J, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T.T, Lambiris M, Ogwal A, Nakiganda J, Mpanga F, Kagwire F, Amutuhaire M, Burri C, Lengeler C, Awor P, Hetzel M.W. Starting at the community: treatment seeking pathways of children with suspected severe malaria in Uganda. medRxiv. 2021(in press). DOI: 10.1101/2021.12.09.21267055

Cleary E, Hetzel M.W, Siba P, Lau C.L, Clements A.C.A. Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction. Malar J. 2021;20:269. DOI: 10.1186/s12936-021-03804-0

Cleary E, Hetzel M.W, Siba P.M, Lau C.L, Clements A.C.A. Correction to: Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction. Malar J. 2021;20:318. DOI: 10.1186/s12936-021-03838-4

Gul D, Rodríguez-Rodríguez D, Nate E, Auwan A, Salib M, Lorry L, Keven J.B, Katusele M, Rosado J, Hofmann N, Ome-Kaius M, Koepfli C, Felger I, Kazura J.W, Hetzel M.W, Mueller I, Karl S, Clements A.C.A, Fowkes F.J.I, Laman M, Robinson L.J. Investigating differences in village-level heterogeneity of malaria infection and household risk factors in Papua New Guinea. Sci Rep. 2021;11:16540. DOI: 10.1038/s41598-021-95959-8

Keven J.B, Katusele M, Vinit R, Rodríguez-Rodríguez D, Hetzel M.W, Robinson L.J, Laman M, Karl S, Foran D.R, Walker E.D. Nonrandom selection and multiple blood feeding of human hosts by Anopheles vectors: implications for malaria transmission in Papua New Guinea. Am J Trop Med Hyg. 2021;105(6):1747-1758. DOI: 10.4269/ajtmh.21-0210

Lautu-Gumal D, Razook Z, Koleala T, Nate E, McEwen S, Timbi D, Hetzel M.W, Lavu E, Tefuarani N, Makita L, Kazura J, Mueller I, Pomat W, Laman M, Robinson L.J, Barry A.E. Surveillance of molecular markers of Plasmodium falciparum artemisinin resistance (kelch13 mutations) in Papua New Guinea between 2016 and 2018. Int J Parasitol Drugs Drug Resist. 2021;16:188-193. DOI: 10.1016/j.ijpddr.2021.06.004

Lee T.T, Omoluabi E, Ayodeji K, Yusuf O, Okon C, Brunner N.C, Delvento G, Signorell A, Lambiris M, Kwiatkowski M, Burri C, Lengeler C, Emedo E, Cheshi F, Hetzel M.W. Treatment-seeking for children with suspected severe malaria attending community health workers and primary health centres in Adamawa State, Nigeria. medRxiv. 2021(in press). DOI: 10.1101/2021.12.01.21267130

Rodríguez-Rodríguez D, Katusele M, Auwun A, Marem M, Robinson L.J, Laman M, Hetzel M.W, Pulford J. Human behavior, livelihood, and malaria transmission in two sites of Papua New Guinea. J Infect Dis. 2021;223(Suppl. 2):S171-S186. DOI: 10.1093/infdis/jiaa402

Seidahmed O.M.E, Kurumop S, Jamea-Maiasa S, Timbi D, Tandrapah A, Hetzel M, Pomat W. Papua New Guinea malaria indicator survey 2019-2020: final report on malaria prevention, infection prevalence, and treatment-seeking. Goroka: Papua New Guinea Institute of Medical Research, PNGIMR, 2021

Grossenbacher B, Holzschuh A, Hofmann N.E, Omar K.A, Stuck L, Fakih B.S, Ali A, Yukich J, Hetzel M.W, Felger I. Molecular methods for tracking residual Plasmodium falciparum transmission in a close-to-elimination setting in Zanzibar. Malar J. 2020;19:50. DOI: 10.1186/s12936-020-3127-x

Hetzel M. PNG’s health data: too much of a good thing – part two. Australia: Devpolicy Blog, 2020

Hetzel M. PNG’s health data: too much of a good thing – part one. Australia: Devpolicy Blog, 2020

Hetzel M.W, Bonfoh B. Towards more balanced representation in Lancet commissions. Lancet. 2020;395(10238):1693-1694. DOI: 10.1016/S0140-6736(20)30617-6

Hetzel M.W, Chitnis N. Reducing malaria transmission with reactive focal interventions. Lancet. 2020;395(10233):1317-1319. DOI: 10.1016/S0140-6736(20)30678-4

Miotto O, Sekihara M, Tachibana S.I, Yamauchi M, Pearson R.D, Amato R, Goncalves S, Mehra S, Noviyanti R, Marfurt J, Auburn S, Price R.N, Mueller I, Ikeda M, Mori T, Hirai M, Tavul L, Hetzel M.W, Laman M, Barry A.E, Ringwald P, Ohashi J, Hombhanje F, Kwiatkowski D.P, Mita T. Emergence of artemisinin-resistant Plasmodium falciparum with kelch13 C580Y mutations on the island of New Guinea. PLoS Pathog. 2020;16(12):e1009133. DOI: 10.1371/journal.ppat.1009133

Stuck L, Fakih B.S, Al-Mafazy A.H, Hofmann N.E, Holzschuh A, Grossenbacher B, Bennett A, Cotter C, Reaves E, Ali A, Van der Horst T, Felger I, Hetzel M.W, Yukich J. Malaria infection prevalence and sensitivity of reactive case detection in Zanzibar. Int J Infect Dis. 2020;97:337-346. DOI: 10.1016/j.ijid.2020.06.017

Van der Horst T, Al-mafazy A.W, Fakih B.S, Stuck L, Ali A, Yukich J, Hetzel M.W. Operational coverage and timeliness of reactive case detection for malaria elimination in Zanzibar, Tanzania. Am J Trop Med Hyg. 2020;102(2):298-306. DOI: 10.4269/ajtmh.19-0505

Brunner N.C, Chacky F, Mandike R, Mohamed A, Runge M, Thawer S.G, Ross A, Vounatsou P, Lengeler C, Molteni F, Hetzel M.W. The potential of pregnant women as a sentinel population for malaria surveillance. Malar J. 2019;18:370. DOI: 10.1186/s12936-019-2999-0

Evaluation Task Force of Roll Back Malaria’s Monitoring and Evaluation Reference Group. Framework for evaluating national malaria programs in moderate and low transmission settings. Chapel Hill, NC, USA: MEASURE Evaluation, 2019

Rodriguez-Rodriguez D, Maraga S, Jamea-Maiasa S, Tandrapah A, Makita L, Siba P.M, Mueller I, Pulford J, Hetzel M. Mapping routine malaria incidence at village level for targeted control in Papua New Guinea. Geospat Health. 2019;14(2):357-360. DOI: 10.4081/gh.2019.798

Rodriguez-Rodriguez D, Maraga S, Lorry L, Robinson L.J, Siba P.M, Mueller I, Pulford J, Ross A, Hetzel M.W. Repeated mosquito net distributions, improved treatment, and trends in malaria cases in sentinel health facilities in Papua New Guinea. Malar J. 2019;18:364. DOI: 10.1186/s12936-019-2993-6