Publications

D'Abbrunzo I, Zampieri E, Ziberna M.B, Bjelošević Žiberna M, Bertoni S, Häberli C, Keiser J, Perissutti B. Sustainable routes to a soluble anthelmintic thiabendazole organic salt. Crystals (Basel). 2026;16(1):63. DOI: 10.3390/cryst16010063

Kshirsagar R, Singh R, Juneja M, Amate P, Häberli C, Keiser J, Sangamwar A.T. Bile salt-polymer ternary solid dispersion improves dissolution and in vivo performance: a case study of mebendazole. J Drug Deliv Sci Technol. 2026;115(Part 3):107847. DOI: 10.1016/j.jddst.2025.107847

Lin Y, Barth-Jaeggi T, Hürlimann E, Beinamaryo P, Kyarisiima H, Harkare H.V, Matagi L, Byarugaba I, Steinmann P, Keiser J, Tediosi F. Cost comparison of school-based mass drug administration of albendazole and ivermectin versus albendazole alone for soil-transmitted helminth control in Uganda. PLoS Negl Trop Dis. 2026;20(1):e0013913. DOI: 10.1371/journal.pntd.0013913

Schneeberger P.H.H, Dommann J, Rahman N, Hürlimann E, Sayasone S, Ali S, Coulibaly J.T, Keiser J. Profound taxonomic and functional gut microbiota alterations associated with trichuriasis: cross-country and country-specific patterns. NPJ Biofilms Microbiomes. 2026(in press). DOI: 10.1038/s41522-026-00911-1

Sprecher V.P, Schnoz A, Biendl S, Hussein H.S, Najim S.O, Ali M.N, Mohammed I.S, Ali S.M, Hattendorf J, Keiser J. Efficacy and safety of ascending doses of orodispersible ivermectin co-administered with albendazole for Trichuris trichiura infections in preschool-aged children in Tanzania: a single-blind, randomised, controlled, dose-ranging, phase 2 trial. Lancet Infect Dis. 2026;26(2):160-169. DOI: 10.1016/s1473-3099(25)00472-4

Ajayi D.T, Orherhe O.M, Pillai G.C, Mouksassi S, Steffens B, Bräm D, Sprecher V, Hofmann D, Buettcher M, Coulibaly J.T, Ali S.M, Keiser J, Pfister M. Pharmacometric analysis to describe pharmacokinetics and exposure-efficacy response of ivermectin in adolescents infected with Trichuris trichiura. J Clin Pharmacol. 2025;65(4):433-440. DOI: 10.1002/jcph.6158

D'Abbrunzo I, Gigli L, Demitri N, Sabena C, Nervi C, Chierotti M.R, Bertoni S, Skoric I, Häberli C, Keiser J, Hasa D, Perissutti B. Higher-order multicomponent crystals as a strategy to decrease the IC50 parameter: the case of praziquantel, niclosamide and acetic acid. J Drug Deliv Sci Technol. 2025;109:106974. DOI: 10.1016/j.jddst.2025.106974

Dupouy B, Karpstein T, Häberli C, Cal M, Rottmann M, Mäser P, Keiser J, Elhabiri M, Davioud-Charvet E. Synthesis of 1,2,3-triazole-methyl-menadione derivatives: evaluation of electrochemical and antiparasitic properties against two blood-dwelling parasites. ChemMedChem. 2025;20(6):e202400731. DOI: 10.1002/cmdc.202400731

Dziwornu G.A, Attram H.D, Häberli C, Masike K, Njoroge M, Keiser J. Benzimidazole analogues active against adult Schistosoma mansoni: SAR analyses, in vivo efficacy in mice, and preliminary mechanistic studies as potential inhibitors of hemozoin formation. Eur J Med Chem. 2025;284:117186. DOI: 10.1016/j.ejmech.2024.117186

Fabbrizi E, Hailu G.S, Ganesan A, Fioravanti R, Zwergel C, Lambona C, Valente S, Fianco G, Iuzzolino A, Trisciuoglio D, Caroli J, Mattevi A, Häberli C, Keiser J, Rotili D, Mai A. Tranylcypromine-based LSD1 inhibitors as useful agents to reduce viability of Schistosoma mansoni. ACS Infect Dis. 2025;11(8):2178-2189. DOI: 10.1021/acsinfecdis.5c00224

Gimmelli R, Papoff G, Fabbrizi E, Guida M, Lalli C, Saccoccia F, Häberli C, Keiser J, Monaldi D, Jung M, Romier C, Rotili D, Mai A, Ruberti G. Benzodeazaoxaflavin sirtuin inhibitors inhibit Schistosoma mansoni Sirt2 and cause phenotypic changes and lethality in schistosomula and adult worm stages. ACS Infect Dis. 2025;11(11):3115-3127. DOI: 10.1021/acsinfecdis.5c00515

Hattendorf J, Keiser J. Chasing the end of helminths: is elimination within reach?. Lancet. 2025;406(10502):420-422. DOI: 10.1016/s0140-6736(25)01094-3

Karpstein T, Kalamatianou A, Keller S, Späne P, Häberli C, Odermatt A, Blacque O, Cariou K, Gasser G, Keiser J. Synthesis and multidisciplinary preclinical investigations of ferrocenyl, ruthenocenyl, and benzyl derivatives of thiabendazole as new drug candidates against soil-transmitted helminth infections. ACS Infect Dis. 2025;11(7):2037-2047. DOI: 10.1021/acsinfecdis.5c00340

Karpstein T, Zhong S, Keller S, Späne P, Häberli C, Panic G, Blacque O, Odermatt A, Cariou K, Gasser G, Keiser J. Multidisciplinary preclinical investigations on ferrocenyl, ruthenocenyl, and benzyl derivatives of niridazole as new drug candidates against Schistosomiasis. ChemMedChem. 2025;20(23):e202500603. DOI: 10.1002/cmdc.202500603

Kouamé N.A, Bär M, Kouadio J.N, Touré S, Keiser J, Coulibaly J.T. Prevalence and risk factors of soil-transmitted helminths in humans and domestic animals in southern Côte d'Ivoire. BMC Infect Dis. 2025;25:983. DOI: 10.1186/s12879-025-11099-8

Leas D.A, Häberli C, White K.L, Shackleford D.M, Jones J.O, Campbell M, Wu J, Kaushik D, Dong Y, Wallick A.I, Charman S.A, Keiser J, Davis P.H, Vennerstrom J.L. Structure-activity relationship of antischistosomal aryl hydantoin (AR102). J Med Chem. 2025;68(20):21725-21738. DOI: 10.1021/acs.jmedchem.5c02056

Lo N.C, Addiss D.G, Buonfrate D, Amor A, Anegagrie M, Bisoffi Z, Bradbury R.S, Keiser J, Kepha S, Khieu V, Krolewiecki A, Mbonigaba J.B, Muñoz J, Mutapi F, Novela V, Vaz Nery S, Coffeng L.E, de Vlas S.J, Bartoszko J, Moja L, Mupfasoni D, Montresor A. Review of the WHO guideline on preventive chemotherapy for public health control of strongyloidiasis. Lancet Infect Dis. 2025;25(3):e146-e152. DOI: 10.1016/s1473-3099(24)00595-4

Lotz C.N, Mrimi E.C, Schneeberger P.H.H, Ali S.M, Hattendorf J, Keiser J. Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials. PLoS Negl Trop Dis. 2025;19(2):e0012872. DOI: 10.1371/journal.pntd.0012872

Lotz C.N, Schneeberger P.H.H, Concu M, Ali S.M, Mrimi E.C, Keiser J. Implementation of real-time PCR assays for diagnosing intestinal protozoa infections. Parasitol Res. 2025;124(4):40. DOI: 10.1007/s00436-025-08483-3

Malan D, Van Niekerk S, Häberli C, Keiser J, Van der Kooy F. In vitro antischistosomal activity of Artemisia species. Acta Trop. 2025;262:107535. DOI: 10.1016/j.actatropica.2025.107535

Panzner U, Utzinger J, Keiser J. Schistosomiasis: cercarial finding and recognizing of human hosts as a prerequisite of invasion. Clin Microbiol Rev. 2025;38(3):e0019624. DOI: 10.1128/cmr.00196-24

Paul-Odeniran K.F, Odeniran P.O, Häberli C, Keiser J, Laughton C.A. Computational and experimental exploration of statin and statin-like compounds as potential treatment of schistosomiasis. PLoS Negl Trop Dis. 2025;19(9):e0013524. DOI: 10.1371/journal.pntd.0013524

Rahman N, Bär M.A, Dommann J, Hürlimann E, Coulibaly J.T, Ali S, Sayasone S, Beinamaryo P, Keiser J, Schneeberger P.H.H. Widespread Trichuris incognita reveals hidden diversity and reshapes understanding of human whipworm infections. Nat Commun. 2025;16:9831. DOI: 10.1038/s41467-025-64516-6

Schnoz A, Sprecher V.P, Biendl S, Hussein H.S, Najim S.O, Ali M.N, Mohammed I.S, Ali S.M, Hattendorf J, Keiser J. Efficacy and safety of moxidectin-albendazole combination therapy for Trichuris trichiura infections in school-aged children: a double-blind, randomised, controlled, superiority trial. Lancet Infect Dis. 2025;25(12):1325-1335. DOI: 10.1016/s1473-3099(25)00344-5

Spangenberg T, Keiser J. In vitro and in vivo activity of praziquantel against schistosome worms. In: Springer Cham, ed. Praziquantel, 107-123. Cham: Springer Science+Business Media, 2025. DOI: 10.1007/978-3-031-97397-0_6

Taylor L, Keiser J. Emodepside for strongyloidiasis: insights from parasite genetics - Authors' reply. Lancet Infect Dis. 2025;25(10):e545. DOI: 10.1016/s1473-3099(25)00465-7

Taylor L, Many S, Jeanguenat H, Hattendorf J, Sayasone S, Keiser J. Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial. Lancet Infect Dis. 2025;25(11):1254-1264. DOI: 10.1016/s1473-3099(25)00255-5

Ueberall M.E, Berchthold M, Häberli C, Lindemann S, Spangenberg T, Keiser J, Grevelding C.G. Merck Open Global Health Library in vitro screening against Schistosoma mansoni identified two new substances with antischistosomal activities for further development. Parasit Vectors. 2025;18:40. DOI: 10.1186/s13071-024-06648-0

Venkatesan A, Chen R, Bär M, Schneeberger P.H.H, Reimer B, Hürlimann E, Coulibaly J.T, Ali S.M, Sayasone S, Soghigian J, Keiser J, Gilleard J.S. Trichuriasis in human patients from Côte d'Ivoire caused by novel Trichuris incognita species with low sensitivity to albendazole/ivermectin combination treatment. Emerg Infect Dis. 2025;31(1):104-114. DOI: 10.3201/eid3101.240995

Brooker S.J, Keiser J, Bundy D.A.P. Soil-transmitted helminths (geohelminths). In: Farrar J,Hotez P.J,Junghanss T,Kang G,Lalloo D,White N.J,Garcia P.J, eds. Manson's Tropical Diseases, 772-796. Amsterdam: Elsevier, 2024. DOI: 10.1016/B978-0-7020-7959-7.00060-9

Cesar-Rodo E, Dupouy B, Häberli C, Strub J.M, Williams D.L, Mäser P, Rottmann M, Keiser J, Lanfranchi D.A, Davioud-Charvet E. Regioselective synthesis of potential non-quinonoid prodrugs of plasmodione: antiparasitic properties against two hemoglobin-feeding parasites and drug metabolism studies. Molecules. 2024;29(22):5268. DOI: 10.3390/molecules29225268

Davie T, Serrat X, Imhof L, Snider J, Štagljar I, Keiser J, Hirano H, Watanabe N, Osada H, Fraser A.G. Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nat Commun. 2024;15:3367. DOI: 10.1038/s41467-024-47331-3

Dommann J, Keiser J, Garneau J, Gandelin A, Casanova C, Keller P.M, Sayasone S, Vonaesch P, Schneeberger P.H.H. Exposure of gut bacterial isolates to the anthelminthic drugs, ivermectin and moxidectin, leads to antibiotic-like phenotypes of growth inhibition and adaptation. Commun Biol. 2024;7:1566. DOI: 10.1038/s42003-024-07135-z

Dommann J, Kerbl-Knapp J, Albertos Torres D, Egli A, Keiser J, Schneeberger P.H.H. A novel barcoded nanopore sequencing workflow of high-quality, full-length bacterial 16S amplicons for taxonomic annotation of bacterial isolates and complex microbial communities. mSystems. 2024;9(10):e0085924. DOI: 10.1128/msystems.00859-24

Emerson P.M, Evans D, Freeman M.C, Hanson C, Kalua K, Keiser J, Krolewiecki A, Leonard L, Levecke B, Matendechero S, Means A.R, Montresor A, Mupfasoni D, Pullan R.L, Rotondo L.A, Stephens M, Sullivan K.M, Walson J.L, Williams T, Utzinger J. Need for a paradigm shift in soil-transmitted helminthiasis control: targeting the right people, in the right place, and with the right drug(s). PLoS Negl Trop Dis. 2024;18(10):e0012521. DOI: 10.1371/journal.pntd.0012521

Fuchs N, Zimmermann R.A, Schwickert M, Gunkel A, Zimmer C, Meta M, Schwickert K, Keiser J, Häberli C, Kiefer W, Schirmeister T. Dual strategy to design new agents targeting Schistosoma mansoni: advancing phenotypic and SmCB1 inhibitors for improved efficacy. ACS Infect Dis. 2024;10(5):1664-1678. DOI: 10.1021/acsinfecdis.4c00020

González Cabrera D, Keiser J, Spangenberg T. Analysis of the physicochemical properties of anti-schistosomal compounds to identify next-generation leads. ACS Med Chem Lett. 2024;15(5):626-630. DOI: 10.1021/acsmedchemlett.4c00026

Gordon C.A, Utzinger J, Muhi S, Becker S.L, Keiser J, Khieu V, Gray D.J. Strongyloidiasis. Nat Rev Dis Primers. 2024;10:6. DOI: 10.1038/s41572-023-00490-x

Grolimund C.M, Utzinger J, Coulibaly J.T, Sayasone S, Ali S.M, Keiser J, Vounatsou P. Modeling transmission mechanism to infer treatment efficacy of different drugs and combination therapy against Trichuris trichiura. Sci Rep. 2024;14:23543. DOI: 10.1038/s41598-024-73164-7

Keiser J, Bouchery T. A step forward in the journey towards hookworm vaccines. Lancet Infect Dis. 2024;24(7):673-674. DOI: 10.1016/s1473-3099(24)00145-2