Unit | Tuberculosis Research

TB Research in the BSL3-Laboratory at Swiss TPH

The TB Research Unit conducts fundamental and translational research, focusing on the biology, immunology and genomic epidemiology of TB. The unit comprises two research groups that interact on a regular basis: The TB Ecology and Evolution Group explores the nature, cause and consequence of the genetic diversity in the Mycobacterium tuberculosis complex, particularly in the context of antibiotic resistance. This group combines experimental work in the laboratory and epidemiological investigation in the field with various population- and functional genomics approaches. The TB Immunology Group conducts in-depth clinical immunological studies to enhance our understanding of the host-pathogen interaction in TB, and for the development of novel diagnostics and host-directed interventions.

Partnerships

An important part of this work relies on our long-term partnerships with collaborators in TB-endemic countries. These include the Ifakara Health Institute in Tanzania, the Noguchi Memorial Institute for Medical Research in Ghana, and the National Centre for Tuberculosis and Lung Disease in Georgia.

Sébastien Gagneux

Sébastien Gagneux, Associate Professor, PhD

Arbues A, Brees D, Chibout S. D, Fox T, Kammuller M, Portevin D. TNF-alpha antagonists differentially induce TGF-beta1-dependent resuscitation of dormant-like Mycobacterium tuberculosis. PLoS Pathog. 2020;16(2):e1008312. DOI: 10.1371/journal.ppat.1008312

Castro R.A.D et al. The genetic background modulates the evolution of fluoroquinolone-resistance in Mycobacterium tuberculosis. Mol Biol Evol. 2020;37(1):195-207. DOI: 10.1093/molbev/msz214

Dötsch A.L. Higher levels of rifampicin resitance in one Mycobacterium tuberculosis-katG mutant. Basel: Swiss Tropical and Public Health Insitute, 2020. MSc

Ezewudo M et al. Author correction: Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. Sci Rep. 2020;10(1):3531. DOI: 10.1038/s41598-020-58955-y

Meyer T. Characterisation of Mycobacterium tuberculosis drug resistance variants in TB patients from Georgia. Basel: Swiss Tropical and Public Health Institute, 2020. MSc