A-HERO - Antihelmintic Research and Optimisation

A-HERO brings together different streams of advanced scientific inquiry, ranging from drug discovery to drug development and combines them in a logical way. The project aims at advancing drug options against schistosomiasis and soil-transmitted helminthiases. Several steps along the drug discovery pipeline are covered: in vivo and vitro studies of compound libraries and repurposed drugs, pharmacokinetic and -dynamic studies and exploratory clinical trials for efficacy and safety assessment. The project will furthermore contribute valuable insights into anthelminthic drug assay development and diagnostics. With the application of novel approaches in the field of drug discovery and preclinical development, the project will lay a strong foundation in anthelminthic research and guide and optimize subsequent drug development.