Preclinical profiling of virosomally formulated B-cell epitope mimetics derived from the novel key malaria vaccine candidates CyRPA and RH5 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/preclinical-profiling-of-virosomally-formulated-b-cell-epitope-mimetics-derived-from-the-novel-key-malaria-vaccine-candidates-cyrpa-and-rh5
Clinical testing of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multivalent
Understanding the human, parasite, vector and environmental interactions driving residual malaria transmission in Papua New Guinea (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/understanding-the-human-parasite-vector-and-environmental-interactions-driving-residual-malaria-transmission-in-papua-new-guinea
The scale-up of malaria control in Papua New Guinea (PNG) has resulted in a significant reduction in the nationwide prevalence and incidence of malaria. However, this effect has not been uniform across [...] address this knowledge gap by: measuring the prevalence and distribution of malaria infection to assess the magnitude of residual malaria at the time of study, studying the Anopheles vectors to characterize local [...] heterogeneity in malaria transmission and the its driving factors is...
Malaria Course in Tanzania and Laos (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/malaria-course-in-tanzania-and-laos
activities in the field of malaria. To improve skills in time management, presenting, writing research proposals. At the end of the course, the participants should be able to manage malaria issues more effectively [...] A four-week postgraduate course on malaria prevention, control & elimination. Course objectives are: Building capacity by reinforcing knowledge and expertise of persons involved in the care of patients
Impact of systems failures in malaria service delivery in Africa (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/impact-of-systems-failures-in-malaria-service-delivery-in-africa
evaluate effective coverage of malaria curative interventions in Sub-Saharan Africa. We quantify excess morbidity and mortality induced by sub-optimal distribution of malaria services incorporating, among [...] Malaria treatment provides individual benefits by curing infection and preventing progression to severe disease. Treatment also provides community-level benefits by reducing the infectious reservoir. However [...] ent and the extent of health benefits achieved by such care, thus has...
MalCommit - Understanding Sexual Commitment and Early Differentiation of Malaria Transmission Stages (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/malcommit-understanding-sexual-commitment-and-early-differentiation-of-malaria-transmission-stages
The project aims to understand the processes responsible for the differentiation of asexual malaria blood stage parasites into sexual forms. The anticipated results may open up new avenues for the development
Community access to rectal artesunate for malaria (CARAMAL): a large-scale observational implementation study in the Democratic Republic of the Congo,... (Publications)
The key to reducing malaria deaths in highly endemic areas is prompt access to quality case management. Given that many severe cases occur at peripheral level, rectal artesunate (RAS) in the form of s [...] determinants for optimal impact. From 2018 to 2020, the Community Access to Rectal Artesunate for Malaria (CARAMAL) project was conducted as a large-scale observational implementation study in the Democratic [...] provide high-quality field evidence on the two issues above, in three remote...
Exploring a tetrahydroquinoline antimalarial hit from the medicines for malaria pathogen box and the identification of its mode of resistance as... (Publications)
of 400 compounds that was made available by Medicines for Malaria Venture (MMV) in 2015. Compound 2 was profiled in in vitro models of malaria and was found to be active against multiple life-cycle stages
