Phytochemical study of <em>Salvia leriifolia</em> roots: rearranged abietane diterpenoids with antiprotozoal activity (Publications)
Phytochemical investigation of the lipophilic extract of the roots of Salvia leriifolia resulted in the isolation of the new rearranged abietane diterpenoids leriifoliol (1) and leriifolione (2), toge
The impact of acute air pollution fluctuations on bronchiectasis pulmonary exacerbation: a case-crossover analysis (Publications)
In bronchiectasis, exacerbations are believed to be triggered by infectious agents, but often no pathogen can be identified. We hypothesized that acute air pollution exposure may be associated with br
A meta-analysis on residential exposure to magnetic fields and the risk of amyotrophic lateral sclerosis (Publications)
Amyotrophic lateral sclerosis (ALS) is caused by the gradual degeneration and death of motor neurons, with mostly unknown etiology. Some risk factors have been suggested for this disease including ext
Assessing strategies against <em>gambiense </em>sleeping sickness through mathematical modeling (Publications)
Background: Control of gambiense sleeping sickness relies predominantly on passive and active screening of people, followed by treatment. Methods: Mathematical modeling explores the potential of 3 com
Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen <em>Orientia tsutsugamushi</em> (Publications)
BACKGROUND: Orientia tsutsugamushi is a clinically important but neglected obligate intracellular bacterial pathogen of the Rickettsiaceae family that causes the potentially life-threatening human dis
Sedentary behaviour in Swiss children and adolescents: disentangling associations with the perceived and objectively measured environment (Publications)
Identifying correlates of sedentary behaviour across all levels of the ecological model and understanding their interrelations is a promising method to plan effective interventions. The present study
Quantifying human-environment interactions using videography in the context of infectious disease transmission (Publications)
Quantitative data on human-environment interactions are needed to fully understand infectious disease transmission processes and conduct accurate risk assessments. Interaction events occur during an i
2<em>H</em>-1,2,3-triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design (Publications)
Macrocyclic inhibitors of rhodesain (RD), a parasitic cysteine protease and drug target for the treatment of human African trypanosomiasis, have shown low metabolic stability at the macrocyclic ether
Repurposing a library of human cathepsin L ligands: identification of macrocyclic lactams as potent rhodesain and <em>trypanosoma brucei... (Publications)
Rhodesain (RD) is a parasitic, human cathepsin L (hCatL) like cysteine protease produced by Trypanosoma brucei ( T. b.) species and a potential drug target for the treatment of human African trypanoso
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial... (Publications)
BACKGROUND: Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines f
