Immuno-gold silver staining assays on capillary-driven microfluidics for the detection of malaria antigens (Publications)
a lack of highly sensitive malaria RDTs that can detect low antigen concentration at the onset of infection. Here, we present a strategy to improve the sensitivity of malaria RDTs by using capillary-driven [...] al to the concentration of antigen in a sample. We illustrate this method using the recombinant malaria antigen Plasmodium falciparum histidine-rich-protein 2 (rPfHRP2) spiked in human serum. This antigen [...] min, which is approaching the desired sensitivity needed in the Target...
Hemozoin-catalyzed precipitation polymerization as an assay for malaria diagnosis (Publications)
Methods to diagnose malaria are of paramount interest to eradicate the disease. Current methods have severe limitations, as they are either costly or not sensitive enough to detect low levels of parasitemia [...] increase is proportional to the concentration of hemozoin, with a detection limit of 0.85 ng mL(-1). Malaria parasites in human blood can be detected down to 10 infected red blood cells muL(-1). The assay could
High cure rates and tolerability of artesunate-amodiaquine and dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in... (Publications)
BACKGROUND: The Tanzanian National Malaria Control Programme (NMCP) and its partners have been implementing regular therapeutic efficacy studies (TES) to monitor the performance of different drugs used [...] mefantrine, which is the first-line anti-malarial for the treatment of uncomplicated falciparum malaria. Data on the performance of other artemisinin-based combinations is urgently needed to support timely [...] parasitological responses of ASAQ and DP for directly observed treatment of...
Human behaviour and residual malaria transmission in Zanzibar: findings from in-depth interviews and direct observation of community events (Publications)
risk of malaria infection during these times. Travel and migration emerged as a crucial issue and participants viewed seasonal workers coming from mainland Tanzania as more likely to have a malaria infection [...] CONCLUSIONS: Targeting malaria interventions effectively is critical and should be informed by a clear understanding of relevant human behaviour. These findings highlight malaria prevention gaps in Zanzibar [...] final phases of malaria elimination. Development and deployment of...
Monitoring of larval habitats and mosquito densities in the Sudan savanna of Mali: implications for malaria vector control (Publications)
the rainy season, vector control in this small hamlet may be a cost-effective way to ameliorate malaria transmission in the 40-times larger village
Spatial analysis of malaria transmission parameters in the rice cultivation area of office du Niger, Mali (Publications)
The effects of rice growth environment on malaria transmission, taking into account spatial correlation, were assessed in the Office du Niger, Mali. Between April 1999 to January 2001, 8 quarterly entomologic [...] and showed low spatial correlations (up to 3.4 km), which suggested that small area variation in malaria transmission results mainly from variations in vector-human contact. Control strategies in rice
Malaria transmission dynamics in Niono, Mali: the effect of the irrigation systems (Publications)
The type of water management and drainage system could be a potential reason for variation in malaria transmission in rice cultivation areas. To investigate this we have compared the population dynamics [...] depth, i.e. casiers and hors-casiers, respectively in the Office du Niger, Mali. We also compared malaria transmission in areas with mixed and casiers plots. Larval collection was performed fortnightly with
