Controlled human malaria infection leads to long-lasting changes in innate and innate-like lymphocyte populations (Publications)
clinically silent. To overcome this limitation, we examined blood samples from a controlled human malaria infection (CHMI) study in a Tanzanian cohort, in which volunteers underwent CHMI with a low or high
Bayesian spatio-temporal modeling of mortality in relation to malaria incidence in western Kenya (Publications)
between malaria transmission intensity and all-cause/malaria mortality. This offers a quick and efficient way to monitor malaria burden. Excess mortality estimates indicate that small changes in malaria incidence [...] spatio-temporal survival models to investigate the relation between mortality (all-cause/malaria-specific) and malaria incidence across all age groups. The analysis adjusted for insecticide-treated net (ITN) [...] positive association with malaria-specific mortality in young...
Eave ribbons treated with transfluthrin can protect both users and non-users against malaria vectors (Publications)
treated with spatial repellents effectively prevent human exposure to outdoor-biting and indoor-biting malaria mosquitoes, and could constitute a scalable and low-cost supplement to current interventions, such [...] ribbons alone. CONCLUSION: Transfluthrin-treated eave ribbons protect both users and non-users against malaria mosquitoes indoors and outdoors. The mosquito-killing property of transfluthrin can magnify the communal
PCR correction strategies for malaria drug trials: updates and clarifications (Publications)
Malaria drug trials conducted in endemic areas face a major challenge in their analysis because it is difficult to establish whether parasitaemia in blood samples collected after treatment indicate drug [...] public and private bodies who are working on the development, deployment, and surveillance of new malaria drugs. We aim to promote discussion around these issues and argue for the adoption of improved s
Mosquito feeding behavior and how it influences residual malaria transmission across Africa (Publications)
an estimated 10.6 million additional malaria cases annually if universal LLIN and IRS coverage was achieved. Higher outdoor biting diminishes the cases of malaria averted by vector control. This reduction [...] times contribute to residual transmission which determines the maximum effectiveness of current malaria prevention. The likelihood mosquitoes feed outside the time of day when LLINs and IRS can protect [...] estimate the public health impact of outdoor biting across Africa. On average 79%...
Modelling the relationship between malaria prevalence as a measure of transmission and mortality across age groups (Publications)
prevalence has been used widely as a measure of malaria transmission, especially in malaria endemic areas. However, its contribution and relationship to malaria mortality across different age groups has not [...] all-cause and malaria-specific mortality. CONCLUSION: Malaria parasitaemia from cross-sectional surveys was associated with mortality across age groups over 4 to 5 year periods with clinical malaria more strongly [...] surveys from the Kisumu HDSS between 2007 and 2015 were used to...
