Closing the malaria prevention gap: measuring and characterizing human behavioral drivers of persistent malaria transmission in Sub-Saharan Africa (Publications)
two-thirds of the reduction in malaria burden over the past two decades. However, progress has begun to stall in recent years highlighting the importance of enhanced malaria prevention efforts. The aim of [...] Malaria kills a person nearly every minute, most often a child under the age of five. While endemic in many parts of the world, a disproportionate burden of cases and deaths are borne by people living [...] living in sub-Saharan Africa. Malaria is transmitted by the female Anopheles...
The effect of community-driven larval source management and house improvement on malaria transmission when added to the standard malaria control... (Publications)
sufficient for malaria elimination. The effects of community-based house improvement (HI) and larval source management (LSM) as supplementary interventions to the Malawi National Malaria Control Programme [...] tion indicated a promising reduction in malaria transmission for the area, but also limited the usefulness of this outcome for measuring differences in malaria transmission among the trial arms. Trial [...] bed net use, neither community-based HI, LSM, nor HI + LSM contributed to further...
Impact of malaria pre-exposure on anti-parasite cellular and humoral immune responses after controlled human malaria infection (Publications)
understand the effect of previous malaria exposure on anti-parasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMI) using cryopreserved [...] sporozoites provide a unique opportunity to study differences in acquisition or re-call of anti-malaria immune responses in individuals from different transmission settings and genetic backgrounds. In [...] In this study, we compared anti-parasite humoral and cellular immune...
Malaria risk in Nigeria: Bayesian geostatistical modelling of 2010 malaria indicator survey data (Publications)
2010, the National Malaria Control Programme with the support of Roll Back Malaria partners implemented a nationally representative Malaria Indicator Survey (MIS), which assembled malaria burden and control [...] ic predictors of malaria risk. The population adjusted risk estimates ranges from 6.46% in Lagos state to 43.33% in Borno. Interventions appear to not have important effect on malaria risk. The odds of [...] and living in rural areas increases the odds of testing positive to malaria...
The public health impact of malaria vaccine RTS,S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and... (Publications)
control programs, assuming continuation of current levels of malaria exposure and of health system performance, will potentially avert 100-580 malaria deaths and 45,000 to 80,000 clinical episodes per 100,000 [...] BACKGROUND: The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact [...] estimated by Bayesian fitting of these models to the site- and time-specific...
Malaria elimination in Isabel Province, Solomon Islands: establishing a surveillance-response system to prevent introduction and reintroduction of... (Publications)
spirit as well as high concern regarding malaria and its importation and there is currently effective malaria passive case detection and management. Conducting malaria screening at ports and airports would [...] Solomon Islands National Malaria Programme is currently focused on intensified control and progressive elimination. Recent control efforts in Isabel Province have reduced their malaria incidence to 2.6/1,000 [...] esponse system is essential when moving towards malaria elimination. Many...
