Immunization of malaria pre-exposed volunteers with PfSPZ Vaccine elicits long-lived IgM invasion-inhibitory and complement-fixing antibodies (Publications)
antibodies are induced following immunization of malaria pre-exposed volunteers with PfSPZ Vaccine. We found that in addition to anti-PfCSP IgG, Malaria pre-exposed volunteers developed anti-PfCSP IgM [...] and Pf sporozoite-binding IgM antibodies are induced following immunization of PfSPZ Vaccine in malaria pre-exposed individuals and that IgM antibodies can inhibit Pf sporozoite invasion into hepatocytes
Sustained malaria control over an 8-year period in Papua New Guinea: the challenge of low-density asymptomatic <em>Plasmodium</em> infections (Publications)
Background: The scale-up of effective malaria control in the last decade has resulted in a substantial decline in the incidence of clinical malaria in many countries. The effects on the proportions of [...] has resulted in reduced malaria transmission potential, but an increasing proportion of gametocyte carriers are asymptomatic and submicroscopic and represent a challenge to malaria control.
malERA: an updated research agenda for combination interventions and modelling in malaria elimination and eradication (Publications)
number of countries embarking on malaria elimination programmes, national and local decisions to select combinations of tools and deployment strategies directed at malaria elimination must address rapidly [...] This paper summarises key advances and priorities since the 2011 presentation of the Malaria Eradication Research Agenda (malERA), with a focus on the combinations of intervention tools and strategies [...] deployment against a heterogeneous transmission background is a challenge. Further...
The Internet: a valuable tool for Roll Back Malaria (Publications)
Roll Back Malaria (RBM) will face a tremendous challenge in halving the current malaria burden by 2010. Thus, the initiative needs to explore novel and innovative approaches. The potential of the Internet [...] build a virtual community and to facilitate the training of a new generation of skilled personel for malaria diagnosis is discussed here. We also argue that investment in information technology is crucial to
Efficacy and cost-effectiveness of environmental management for malaria control (Publications)
implementation, the programme had averted an estimated 4173 deaths and 161,205 malaria attacks. The estimated costs per death and malaria attack averted were US$ 858 and US$ 22.20, respectively. Over the initial [...] Roll back malaria (RBM) aims at halving the current burden of the disease by the year 2010. The focus is on sub-Saharan Africa, and it is proposed to implement efficacious and cost-effective control strategies [...] of the potential of environmental management. We reviewed the...
<em>Falciparum </em>malaria presenting with pruritic rashes (Publications)
Rash is not generally believed to be a symptom of malaria. Two cases of acute falciparum malaria in non-immune residents of Mozambique who presented with pruritic rashes are reported. One case exhibited [...] Review of the literature reveals cases of malaria from India, East Africa, France, and the USA presenting with urticaria or a pruritic rash. Previous exposure to malaria may be a factor in these presentations [...] ns. Physicians should not discount the diagnosis of malaria in patients with...
The economic payoffs of integrated malaria control in the Zambian copperbelt between 1930 and 1950 (Publications)
suggested that malaria is delaying the economic development of countries that are most severely affected by the disease. Several studies have documented the economic consequences of malaria at the household [...] economic impact of malaria on the industrial and service sectors that will probably become the backbone of many developing economies. We estimate the economic effects of integrated malaria control implemented [...] 284 malaria attacks and 942,347 work shift losses were averted. Overall,...
Cytochrome P450 6M2 from the malaria vector <em>Anopheles gambiae</em> metabolizes pyrethroids: sequential metabolism of deltamethrin revealed (Publications)
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes. Cytochome P450-mediated detoxification is an important resistance mechanism [...] metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria
Structural and functional characterisation of the toll like receptor 9 of <em>Aotus nancymaae</em>, a non-human primate model for malaria vaccine... (Publications)
In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between [...] sequence conservation of Aona-TLR-9 reinforces the suitability of A. nancymaae as animal model for malaria subunit vaccine development
