Structure–activity relationship studies and <em>Plasmodium</em> life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl... (Publications)
Structure-activity relationship studies involving N-aryl-3-trifluoromethyl pyrido[1,2-a] benzimidazoles (PBI) identified several compounds possessing potent in vitro activities against the asexual blo
Measuring health facility readiness and its effects on severe malaria outcomes in Uganda (Publications)
role of health service delivery to the malaria decline in Uganda We developed a methodology to quantify health facility readiness and assessed its role on severe malaria outcomes among lower-level facilities [...] facilities (HCIIIs and HCIIs) in the country. Malaria data was extracted from the Health Management Information System (HMIS). General service and malaria-specific readiness indicators were obtained from the [...] factorial axes. Geostatistical models assessed the effect of facility...
MALDI-TOF mass spectrometry combined with machine learning algorithms to identify protein profiles related to malaria infection in human sera from... (Publications)
In sub-Saharan Africa, Plasmodium falciparum is the most prevalent species of malaria parasites. In endemic areas, malaria is mainly diagnosed using microscopy or rapid diagnostic tests (RDTs), which have [...] but is rarely used for parasite detection. This study aims to employ MALDI-TOF MS for identifying malaria by distinguishing P. falciparum-positive from P. falciparum-negative sera. METHODS: Sera were obtained [...] MS combined with ML might be applied for detection of protein profiles...
Asymptomatic malaria reservoirs are the last challenge in the elimination in Cambodia (Publications)
stages of malaria elimination and aims to eliminate all species of human malaria by 2025. Despite tremendous progress, eliminating malaria in Cambodia has proven to be challenging due to pockets of residual [...] asymptomatic malaria reservoirs. Understanding the extent of asymptomatic malaria reservoirs in 'last-mile' communities such as those in Mondulkiri and Kampong Speu, is vital for an effective malaria elimination [...] BACKGROUND: Malaria, a mosquito-borne disease, is a serious...
Trends in malaria prevalence among school-age children in Mainland Tanzania, 2015-2023: a multilevel survey analysis (Publications)
assessed for malaria control intervention coverage and other malaria-related parameters. A multilevel mixed-effects logistic regression model was used to assess associated risk factors. Overall malaria prevalence [...] high-transmission areas, school-aged children have higher malaria prevalence and contribute significantly to the transmission reservoir. Malaria infections can be asymptomatic or present with symptoms which [...] which may contribute to anaemia, severe illness and fatal malaria....
Identifying gaps in protection from malaria vector biting in rural Cambodia using an entomological assessment and human behaviour observations (Publications)
access, high-risk populations for malaria in Cambodia. Despite the availability of long-lasting insecticidal nets (LLINs) and/or hammock nets (LLIHNs), continued malaria transmission indicates gaps in protection [...] (LLINs, LLIHNs) and newly introduced bite prevention tools (VPSRs, ITCs, and TRs). To help achieve malaria elimination, human behaviour data on intervention use and behaviour patterns should be evaluated
Health systems and global progress towards malaria elimination, 2000-2016 (Publications)
progress in malaria control in the 2000-2016 period among 105 countries. Additional analysis was performed within malaria burden groups. RESULTS: There was large heterogeneity in progress in malaria control [...] BACKGROUND: As more countries progress towards malaria elimination, a better understanding of the most critical health system features for enabling and supporting malaria control and elimination is needed. METHODS: [...] with reductions in malaria burden between 2000 and 2016. In...
