Development of a simple microarray for genotyping HIV-1 drug resistance mutations in the reverse transcriptase gene in rural Tanzania (Publications)
OBJECTIVE: Aiming at a simple, inexpensive and robust tool for HIV-1 drug resistance genotyping during antiretroviral therapy (ART) we developed and validated a microarray-based detection of 25 drug r
Synthesis and antimalarial testing of neocryptolepine analogues: addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines (Publications)
This report describes the synthesis, and in vitro and in vivo antimalarial evaluations of certain ester-modified neocryptolepine (5-methyl-5H-indolo[2,3-b]quinoline) derivatives. The modifications wer
Differences in conformational dynamics between <em>Plasmodium falciparum</em> and human Hsp90 orthologues enable the structure-based discovery of... (Publications)
The high sequence conservation of druggable pockets of closely related proteins can make it challenging to develop selective inhibitors. We designed a new drug discovery approach that exploits both th
Ferrocenyl, ruthenocenyl, and benzyl oxamniquine derivatives with cross-species activity against <em>Schistosoma mansoni </em>and <em>Schistosoma... (Publications)
Schistosomiasis is a parasitic disease that affects more than 250 million people annually, mostly children in poor, tropical, rural areas. Only one treatment (praziquantel) is available, putting contr
Malaria prevention strategies and recommendations, from chemoprophylaxis to stand-by emergency treatment: a 10-year prospective study in a Swiss... (Publications)
Background: There are several possible malaria prevention strategies for travellers. In Switzerland, chemoprophylaxis (CP) is recommended for persons visiting areas highly endemic for malaria and stan
The quantified self during travel: mapping health in a prospective cohort of travellers (Publications)
Background: Travel medicine research has remained relatively unchanged in the face of rapid expansion of international travel and is unlikely to meet health challenges beyond infectious diseases. Our
Nasopharyngeal pneumococcal density is associated with viral activity but not with use of improved stoves among young Andean children (Publications)
BACKGROUND: Indoor smoke exposure is common in developing countries and may influence nasopharyngeal (NP) pneumococcal colonization density and risk of acute respiratory illness. We compared colonizat
Portable functional neuroimaging as an environmental epidemiology tool: a how-to guide for the use of fNIRS in field studies (Publications)
SUMMARY: The widespread application of functional neuroimaging within the field of environmental epidemiology has the potential to greatly enhance our understanding of how environmental toxicants affe
