A tool box for operational mosquito larval control: preliminary results and early lessons from the Urban Malaria Control Programme in Dar es Salaam,... (Publications)
be protected from malaria by controlling aquatic stages of mosquitoes if cost-effective and scalable implementation systems can be designed. METHODS: A recently initiated Urban Malaria Control Programme [...] levels, respectively. One year of community-based larviciding reduced transmission by the primary malaria vector, Anopheles gambiae s.l., by 31% (95% C.I. = 21.6-37.6%; p = 0.04). CONCLUSION: This novel [...] novel management, monitoring and evaluation system for implementing routine...
Artesunate-mefloquine combination therapy in acute <em>Plasmodium falciparum</em> malaria in young children: a field study regarding neurological and... (Publications)
BACKGROUND: Mefloquine-artesunate combination therapy for uncomplicated falciparum malaria is one of the treatments used in African children. Data concerning neurological safety in adults and children [...] study was conducted among African children between 10 and 20 kg with acute uncomplicated falciparum malaria. They were treated over three consecutive days with a paediatric fixed-dose combination of artesunate [...] RESULTS: From December 2007 to March 2009, 220 children with uncomplicated...
Prices and mark-ups on antimalarials: evidence from nationally representative studies in six malaria-endemic countries (Publications)
sector is an important source of treatment for malaria. However, private patients face high prices for the recommended treatment for uncomplicated malaria, artemisinin combination therapies (ACTs), which
Defining the relationship between infection prevalence and clinical incidence of<em> Plasmodium falciparum</em> malaria (Publications)
falciparum malaria cases. In response, cartographic approaches have been developed that link maps of infection prevalence with mathematical relationships to predict the incidence rate of clinical malaria. Mi
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
clinical malaria in which parasites matched the vaccine in the entire circumsporozoite protein C-terminal (139 infections), as compared with 33.4% (95% CI, 29.3 to 37.2) against mismatched malaria (1951 [...] age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria. The overall vaccine efficacy in this age category [...] protein of Plasmodium falciparum and has partial protective efficacy against...
Time to move from presumptive malaria treatment to laboratory-confirmed diagnosis and treatment in African children with fever (Publications)
declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagnostic tests mean it may be time for this policy to change. This [...] to support a shift toward laboratory-confirmed rather than presumptive diagnosis and treatment of malaria in children under five
No fever, no malaria? A diagnostic challenge in an immunocompromised patient (Publications)
women with proven malaria tropicana. Fever was not reported with this patient. We conclude that the concept of using fever as a primary surrogate indicator for the presence of malaria should be used with
Safety, tolerability and immunogenicity of new formulations of the <em>Plasmodium falciparum </em>malaria peptide SPf66 combined with the... (Publications)
SPf66 is a synthetic malaria peptide vaccine, which has been widely tested in combination with aluminium hydroxide (alum) as the adjuvant. Since this formulation is weakly immunogenic, we sought to improve
