Malaria eradication and elimination: views on how to translate a vision into reality (Publications)
deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and [...] which malaria might eventually be eradicated. Their collective views highlight the challenges and opportunities, and explain how multi-factorial and integrated processes could eventually make malaria eradication
Implementation of the global plan for insecticide resistance management in malaria vectors: progress, challenges and the way forward (Publications)
resistance of malaria vectors to insecticides, particularly to pyrethroids which are widely used in insecticide-treated nets. The Global Plan for Insecticide Resistance Management in malaria vectors (GPIRM) [...] to effective malaria prevention. Aligning efforts and assigning the needed resources will ensure the optimal implementation of GPIRM with the ultimate goal of maintaining effective malaria vector control [...] (GPIRM), released in May 2012, is a collective strategy for the malaria...
An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic... (Publications)
has the highest number of severe malaria cases in the world. In early 2012, the National Malaria Control Programme (NMCP) changed the policy for treating severe malaria in children and adults from injectable
Effective coverage and systems effectiveness for malaria case management in sub-Saharan African countries (Publications)
Scale-up of malaria preventive and control interventions over the last decade resulted in substantial declines in mortality and morbidity from the disease in sub-Saharan Africa and many other parts of [...] infectious reservoir and averting emergence and spread of drug resistance. However many patients with malaria do not access care, providers do not comply with treatment guidelines, and hence, patients do not [...] seeking, provider compliance, adherence, and quality of medication to estimate...
Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015) (Publications)
reviews or consultations on malaria terminology, malaria in pregnancy, and the feasibility of eradication; as well as updates from the World Health Organization Global Malaria Programme regarding their strategy [...] The Malaria Policy Advisory Committee to the World Health Organization held its seventh meeting in Geneva, Switzerland from 5 to 7 March 2015. This article provides a summary of the discussions, conclusions [...] policy setting processes. Policy statements, position statements, and...
Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment (Publications)
BACKGROUND: Malaria prevalence, clinical incidence, treatment, and transmission rates are dynamically interrelated. Prevalence is often considered a measure of malaria transmission, but treatment of clinical [...] clinical malaria reduces prevalence, and consequently also infectiousness to the mosquito vector and onward transmission. The impact of the frequency of treatment on prevalence in a population is generally [...] generally not considered. This can lead to potential underestimation of ma...
Artemether-lumefantrine treatment of uncomplicated <em>Plasmodium falciparum</em> malaria: a systematic review and meta-analysis of day 7 lumefantrine... (Publications)
BACKGROUND: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well [...] data from patients treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria, to define therapeutic day 7 lumefantrine concentrations and identify patient factors that substantially [...] associated with > 98 % cure rates (if parasitemia /=200 ng/ml and high cure...
Assessment of parental perception of malaria vaccine in Tanzania (Publications)
and willingness to use malaria vaccines and to provide policy makers with evidence-based information on the best strategies to engage communities to manage the introduction of malaria vaccine in Tanzania [...] variables of interests were awareness and willingness to use a malaria vaccine. The main outcome measure was willingness to use a malaria vaccine. Logistic regression was used to examine the influence [...] BACKGROUND: Clinical trials of the RTS,S malaria vaccine have completed Phase III...
Spatial and temporal variation of malaria entomological parameters at the onset of a hydro-agricultural development in central Côte d'Ivoire (Publications)
e heterogeneity of malaria transmission is essential for the design of effective prevention, control and elimination interventions. The spatial and temporal distribution of malaria vectors was investigated [...] correlated with malaria transmission. CONCLUSION: In this study setting, located in the bioclimatic transition zone of Cote d'Ivoire, rice cultivation was not observed to increase malaria transmission. The [...] observed in two of the five villages located in close proximity to the...
