Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens... (Publications)
We evaluated the impact of intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP), which was given at ages 3, 4, and 9 months through the Expanded Program on Immunizat
Synthesis and biological properties of a rhodacyanine derivative, Ssj-127, having high efficacy against malaria protozoa (Publications)
One of rhodacyanine derivatives, SSJ-127 (1), showed a complete cure of a mouse model infected with Plasmodium berghei by subcutaneous administration. The synthesis, in vitro activities against severa
An algorithm for the clinical differentiation of malaria and typhoid: a preliminary communication (Publications)
The objective of this study was to determine which clinical features of typhoid and malaria are most helpful in distinguishing the two diseases among Papua New Guinean highlanders. In a study of 35 pa
The W-Beijing lineage of <em>Mycobacterium tuberculosis</em> overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated (Publications)
The Beijing family of Mycobacterium tuberculosis strains has been associated with epidemic spread and an increased likelihood of developing drug resistance. The characteristics that predispose this fa
Development and adaptation of tensile strength by bones in the extremities in response to physical training exemplified by the tibia (Publications)
Results from an in vivo assessment of the bending stiffness of human tibiae with a new method demonstrate that bone mineral measurements are not a suitable predictor to evaluate changes of mechanical
Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities (Publications)
Trypanothione reductase (TR) is an essential enzyme of trypanosomatids and therefore a promising target for the development of new drugs against African sleeping sickness and Chagas' disease. Diaryl s
Methods development for epidemiologic investigations of the health effects of prolonged ozone exposure. Part I: Variability of pulmonary function... (Publications)
The acute and subacute effects of ambient concentrations of ozone on lung function have been studied extensively in a variety of settings. Such studies generally have focused on measures of function t