Design of a phase III cluster randomized trial to assess the efficacy and safety of a malaria transmission blocking vaccine (Publications)
falciparum malaria transmission targeting sexual, sporogonic, or mosquito-stage antigens (SSM-VIMT) are currently under development to reduce malaria transmission. An international group of malaria experts [...] estimates suggest that such a trial is feasible, and within the range of previously supported trials of malaria interventions, although substantial issues to implementation exist.
Humoral and cell-mediated immunity to the <em>Plasmodium falciparum</em> ring-infected erythrocyte surface antigen in an adult population exposed to... (Publications)
in Papua New Guinea highly endemic for malaria. Two hundred fourteen adult individuals were selected for studies to assess their immune responses against the malaria vaccine candidate ring-infected erythrocyte [...] to be age dependent. Total anti-RESA IgG antibodies were not correlated with protection against malaria as measured by parasite prevalence, parasite density, or health center attendance. In contrast,
Relationship between humoral response to <em>Plasmodium falciparum</em> merozoite surface antigen-2 and malaria morbidity in a highly endemic area of... (Publications)
of MSA-2 are associated with fewer fever episodes and less anemia, both known to be indicators of malaria morbidity.
Multiplex real-time PCR for the diagnosis of malaria: correlation with microscopy (Publications)
Abstract Malaria is generally diagnosed by microscopy and rapid antigen testing. Molecular methods become more widely used. In the present study, the contribution of a quantitative multiplex malaria PCR was
Participatory mapping of target areas to enable operational larval source management to suppress malaria vector mosquitoes in Dar es Salaam, Tanzania (Publications)
Half of the population of Africa will soon live in towns and cities where it can be protected from malaria by controlling aquatic stages of mosquitoes. Rigorous but affordable and scaleable methods for mapping [...] identification and inclusion of these key areas, as well as more equal distribution of the workload of malaria control field staff. CONCLUSIONS: The procedure developed enables complete coverage of targeted areas [...] affordable, and requires minimal technical skills. This approach...
An estimation of the entomological inoculation rate for Ifakara: a semi-urban area in a region of intense malaria transmission in Tanzania (Publications)
An entomological study on vectors of malaria and their relative contribution to Plasmodium falciparum transmission in the semi-urban area of Ifakara, south-eastern Tanzania, was conducted. A total of 32
Passive immunoprotection of <em>Plasmodium falciparum</em>-infected mice designates the CyRPA as candidate malaria vaccine antigen (Publications)
An effective malaria vaccine could prove to be the most cost-effective and efficacious means of preventing severe disease and death from malaria. In an endeavor to identify novel vaccine targets, we tested [...] represents an unprecedented in vivo model for quantitative comparison of the functional potencies of malaria-specific Abs. Our data suggest a role for CyRPA in erythrocyte invasion by the merozoite. Inhibition [...] merozoite invasion by CyRPA-specific mAbs in vitro and in vivo renders...
