Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age (Publications)
BACKGROUND: Plasmodium falciparum malaria is a pressing global health problem. A previous study of the malaria vaccine RTS,S (which targets the circumsporozoite protein), given with an adjuvant system [...] system (AS02A), showed a 30% rate of protection against clinical malaria in children 1 to 4 years of age. We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children [...] completed the study procedures according to the protocol, the cumulative number...
Molecular approaches to epidemiology and clinical aspects of malaria (Publications)
young children. Fundamental to the development of new tools for malaria control in humans is an increased understanding of key features of malaria infection, such as the diversity of outcome in different i [...] increase our understanding of the epidemiology and clinical manifestations of malaria, as discussed at the Molecular Approaches to Malaria conference (MAM2000), Lorne, Australia, 2-5 February 2000 [...] Malaria is a problem of global importance, responsible for 1-2 million deaths per...
Country planning for health interventions under development: lessons from the malaria vaccine decision-making framework and implications for other new... (Publications)
development will be supported by data (e.g. malaria disease burden; roles of other malaria interventions; malaria vaccine impact; economic and financial issues; malaria vaccine efficacy, quality and safety) [...] paper describes research into the anticipated processes and data needed to inform decision making on malaria vaccines, the most advanced of which is still in phase 3 trials. From 2006 to 2008, a series of country [...] consultations in Africa led to the development of a guide to assist...
