Three different <em>Plasmodium</em> species show similar patterns of clinical tolerance of malaria infection (Publications)
data on the age dependence of tolerance in other species of human malaria. METHODS: Parasite densities measured in 24,386 presumptive malaria cases at two local health centres in the Wosera area of Papua New [...] to the logarithm of the parasite density for all three malaria species, with little age variation in the relationship for P. vivax or P. malariae. P. falciparum shows more age variation in disease incidence [...] BACKGROUND: In areas where malaria endemicity is high, many people...
Spiroindolones, a potent compound class for the treatment of malaria (Publications)
etic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model
Malaria ecotypes and stratification (Publications)
the variability of malaria, control programmes need to stratify their malaria problem into a number of smaller units. Such stratification may be based on the epidemiology of malaria or on its determinants [...] its usefulness for current malaria control as well as for malaria modelling on the basis of published research. Journal and grey literature was searched for articles on malaria or Anopheles combined with [...] cost-effectiveness of malaria control strategies in different scenarios should...
The changing epidemiology of malaria in Ifakara Town, southern Tanzania (Publications)
Between 1995 and 2000 there were marked changes in the epidemiology of malaria in Ifakara, southern Tanzania. We documented these changes using parasitological and clinical data from a series of community- [...] age-specific parasite prevalence in the community-based cohort studies. The incidence of clinical malaria in placebo-receiving infants in additional study cohorts dropped from 0.8 in 1995 to 0.43 episodes
Intermittent treatment for malaria and anaemia control at time of routine vaccinations in Tanzania infants: a randomised, placebo-controlled trial (Publications)
BACKGROUND: Clinical malaria and severe anaemia are major causes of paediatric hospital admission and death in many malaria-endemic settings. In the absence of an effective and affordable vaccine, control [...] were not affected by the intervention. INTERPRETATION: This new approach to malaria control reduced the rate of clinical malaria and severe anaemia by delivering an available and affordable drug through [...] assess the efficacy and safety of intermittent sulphadoxine-pyrimethamine...
Associations of peak shifts in age-prevalence for human malarias with bednet coverage (Publications)
Effects of bednet coverage (C) on prevalence of malaria were analysed using data from 1990-92 from 9 Papua New Guinean villages. Effects of coverage varied by age, resulting in a shift in age of peak [...] for Plasmodium falciparum, from 3.4 to 4.9 years for P. vivax and from 11.0 to 16.8 years for P. malariae. In small areas with no bednets the age distribution of P. falciparum parasitaemia was like that [...] mesoendemicity. Thus, protracted use of bednets can result in profound changes in...
