Spatio-temporal dynamics of malaria in Rwanda between 2012 and 2022: a demography-specific analysis (Publications)
eventually interrupt malaria transmission, the disease remains a pressing public health problem, especially in sub-Saharan Africa. This study presents a detailed spatio-temporal analysis of malaria transmission [...] insights into the evolving patterns of malaria and to inform and tailor effective public health strategies. METHODS: The study used yearly aggregated data of malaria cases from the Rwanda health management [...] temporal patterns of relative risks and to identify clusters of malaria...
Field evaluation of a volatile pyrethroid spatial repellent and etofenprox treated clothing for outdoor protection against forest malaria vectors in... (Publications)
Cambodia's goal to eliminate malaria by 2025 is challenged by persistent transmission in forest and forest fringe areas, where people are exposed to Anopheles mosquito bites during the day and night. Volatile [...] the potential to reduce outdoor and daytime Anopheles biting, offering valuable contributions to malaria elimination efforts in Cambodia and the Greater Mekong Subregion, contingent upon achieving effective
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
Malaria remains a global health concern as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of [...] Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed efficacy in a mouse model of human malaria after oral dosing. SW584 had a low propensity to generate resistance (minimum inoculum for resistance
Insights into the biology and insecticide susceptibility of the secondary malaria vector <em>Anopheles parensis</em> in an area with long-term use of... (Publications)
at least 11 sibling species, with Anopheles funestus Giles being the most studied and significant malaria vector. Other species, like Anopheles parensis, are understudied despite their potential role in [...] lity of An. parensis. Primarily feeding on non-human hosts, An. parensis is less significant in malaria transmission than more anthropophilic vectors. Unlike the pyrethroid-resistant An. funestus sensu [...] findings provide a foundation for future research and may inform control strategies...
Determinants of malaria infection among under five children in Gursum district of Somali region, eastern Ethiopia (Publications)
and not receiving malaria health information [AOR = 2.12 (1.06-4.21)]. Additionally, proximity to malaria vector breeding habitats [AOR = 4.74 (2.27-9.90)] was significant for malaria positivity. These [...] as the primary determinants of malaria positivity among U5 children in the Gursum district. CONCLUSION: The study indicates that critical factors contributing to malaria positivity among U5 children in [...] BACKGROUND: Despite significant efforts to control malaria infections in recent...
Elevating larval source management as a key strategy for controlling malaria and other vector-borne diseases in Africa (Publications)
but is rarely adopted where funds are limited. The World Health Organization (WHO) guidelines on malaria prevention recommend the use of LSM as a supplementary intervention to the core vector control methods [...] effectiveness to support wide-scale implementation. However, the stagnation of progress towards malaria elimination demands that we consider additional options to the current emphasis on insecticidal [...] detailed online expert discussions, (b) a narrative review of countries that...
Whole-genome sieve analysis: identification of protective malaria antigens by leveraging allele-specific vaccine efficacy (Publications)
Discovery of new protective malaria antigens will enable the development of novel vaccine formulations with potentially higher efficacy. While several high-throughput experimental approaches enable the
Population-based prevalence of antibiotic residuals in low, moderate and high malaria endemicity areas in Tanzania (Publications)
antibiotic use may be higher among malaria-negative patients compared to malaria-positive ones, but uncertainty persists, particularly in regions with varying malaria prevalence. This study measured antibiotic [...] directly correlate with malaria endemicity but was influenced by healthcare practices, including co-prescription of antibiotics and antimalarials. The higher antibiotic use in malaria-negative cases highlights [...] antibiotic residuals in three Tanzanian regions with varying malaria...
