Climate change, malaria and neglected tropical diseases: a scoping review (Publications)
To explore the effects of climate change on malaria and 20 neglected tropical diseases (NTDs), and potential effect amelioration through mitigation and adaptation, we searched for papers published from [...] 1543 full-text papers were assessed. Of 511 papers meeting the inclusion criteria, 185 studied malaria, 181 dengue and chikungunya and 53 leishmaniasis; other NTDs were relatively understudied. Mitigation [...] (34%) and adaption strategies in 24 (5%). Amplitude and direction of effects of...
Severe outcomes of malaria in children under time-varying exposure (Publications)
Plasmodium falciparum severe malaria dataset to better understand the relationship between prevalence and incidence of malaria pediatric hospitalizations - a proxy of malaria severe outcomes- in East-Africa [...] In malaria epidemiology, interpolation frameworks based on available observations are critical for policy decisions and interpreting disease burden. Updating our understanding of the empirical evidence [...] dynamics, and subsequent protection patterns in children, substantially...
Regulation of sexual commitment in malaria parasites: a complex affair (Publications)
Malaria blood stage parasites commit to either one of two distinct cellular fates while developing within erythrocytes of their mammalian host: they either undergo another round of asexual replication [...] may support or impair the ultimate goal of human-to-human transmission via the mosquito vector. Malaria parasites therefore evolved strategies to control investments into asexual proliferation versus [...] underlying the control and environmental modulation of sexual commitment in the two...
The essential malaria protein <em>Pf</em>CyRPA targets glycans to invade erythrocytes (Publications)
Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an invasion complex protein essential [...] immunotherapy, or a vaccine-primed immune response is a promising strategy to prevent and treat malaria.
Optimizing malaria vector control in the Greater Mekong Subregion: a systematic review and mathematical modelling study to identify desirable... (Publications)
the daytime and night-time to advance malaria elimination. METHODS: We conducted systematic literature searches to generate a bionomic dataset of the main malaria vectors in the GMS, including human blood
Relative effects of climate factors and malaria control interventions on changes of parasitaemia risk in Burkina Faso from 2014 to 2017/2018 (Publications)
the role of malaria control interventions and climatic factors in influencing changes in the risk of malaria parasitaemia. METHODS: Bayesian logistic geostatistical models were fitted on Malaria Indicator [...] Burkina Faso, the prevalence of malaria has decreased over the past two decades, following the scale-up of control interventions. The successful development of malaria parasites depends on several climatic [...] obtained in 2014 and 2017/2018 to estimate the effects of malaria control...
The influence of jittering DHS cluster locations on geostatistical model-based estimates of malaria risk in Cameroon (Publications)
surveys such as the Demographic and Health Surveys (DHS) and the Malaria Indicator Surveys (MIS) are routinely carried out to assess the malaria risk and the coverage of related interventions. A two-stage sampling [...] the influence of jittering on the estimates of the geographical distribution of malaria risk and on the effects of malaria control interventions using data from the latest MIS in Cameroon. Methods We generated [...] geostatistical variable selection was applied to identify the...
