Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation: a WorldWide Antimalarial... (Publications)
count during acute uncomplicated malaria, and estimate the impact of using an assumed value of WBC on estimates of parasite density and clearance. METHODS: Uncomplicated malaria drug efficacy studies that measured [...] and vivax (n = 2678) malaria, respectively. At presentation, higher WBC counts were seen among patients with higher parasitaemia, severe anaemia and, for individuals with vivax malaria, in regions with shorter [...] reference. RESULTS: Eighty-four studies enrolling 27,656...
Geo-epidemiology of malaria incidence in the Vhembe District to guide targeted elimination strategies, South-Africa, 2015-2018: a local resurgence (Publications)
to classify the 474 smoothed malaria incidence curves. Thereafter, validity indices were used to determine the number of malaria incidence patterns. The cumulative malaria incidence of the study area was [...] Findings show also unusual malaria phenomena in Vhembe District that hinder malaria elimination in South Africa. Assessing the factors associated with these unusual malaria phenome would be helpful on [...] results. Therefore, in the process of refining local malaria control and...
Similar prevalence of <em>Plasmodium falciparum</em> and Non-<em>P. falciparum</em> malaria infections among schoolchildren, Tanzania (Publications)
ovale infections were single-species infections, and 35% of those were detected in low malaria endemic regions. P. malariae infections were predominantly (73%) co-infections with P. falciparum. P. vivax was [...] Achieving malaria elimination requires considering both Plasmodium falciparum and non-P. falciparum infections. We determined prevalence and geographic distribution of 4 Plasmodium spp. by performing PCR [...] during 2017. Among 3,456 schoolchildren, 22% had P. falciparum, 24% had P....
A chromosomal reference genome sequence for the malaria mosquito <em>Anopheles gambia, </em>Giles, 1902, Ifakara strain (Publications)
We present a genome assembly from an individual female Anopheles gambiae (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), Ifakara strain. The genome sequence is 264 megabases in span. Most
A randomized, double-blind placebo-control study assessing the protective efficacy of an odour-based 'push-pull' malaria vector control strategy in... (Publications)
Novel malaria vector control strategies targeting the odour-orientation of mosquitoes during host-seeking, such as 'attract-and-kill' or 'push-and-pull', have been suggested as complementary tools to indoor [...] densities using light-traps. None of the interventions provided any protection from outdoor biting malaria vectors. The 'push' reduced indoor vector densities dominated by Anopheles funestus by around two
The MTego trap: a potential tool for monitoring malaria and arbovirus vectors (Publications)
used interchangeably with the BGP trap for sampling anthropophilic mosquitoes including African malaria vectors An. gambiae and An. funestus and the principal arbovirus vector Ae. aegypti.
Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda (Publications)
than five years with suspected severe malaria. An observational study in Uganda enrolled children below five years presenting to CHWs with signs of severe malaria. Children were followed up 28 days after [...] Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public health facility or a designated public referral health facility (RHF). Caregivers do not always
The beauty of disease modelling (Page)
https://www.swisstph.ch/en/impact-stories/the-beauty-of-disease-modelling
modelling for malaria vaccines? Similar to vaccines, we often ask questions about how we can can reduce the burden of disease. Many of the malaria models that were created to look at malaria vaccines have [...] modelling here is not just estimating the impact of the malaria vaccine or a single intervention but we can ask a whole range of questions about malaria disease dynamics, intervention packages and drug resistance [...] n packages for different national malaria control programmes....
“It is a privilege to be able to bring science to the bedside” (Page)
https://www.swisstph.ch/en/impact-stories/it-is-a-privilege-to-be-able-to-bring-science-to-the-bedside
test a drug for a neglected disease such as malaria, the trial can become more complex, because we have to go where the malaria patients are, i.e., to a malaria-endemic country such as the DRC. Such sites [...] very effective and affordable medicines for malaria? Yes, artemisinin-based combination therapies (ACTs) are still the standard of care for treating malaria and remain very effective. However, we are seeing [...] in the fight against malaria? What is unique about Swiss TPH is that we work...
