TKK130 is a 3-hydroxy-propanamidine (HPA) with potent antimalarial <em>in vivo</em> activity and a high barrier to resistance (Publications)
Malaria continues to pose a significant burden on populations in endemic areas and requires innovative treatment options. Here, we report the synthesis and preclinical evaluation of the novel 3-hydrox
Determinants of malaria infection among under five children in Gursum district of Somali region, eastern Ethiopia (Publications)
BACKGROUND: Despite significant efforts to control malaria infections in recent years, new infection rates continue to pose a major public health challenge in sub-Saharan Africa, including Ethiopia. T
Breaking the dogma of intravenous treatment for infective endocarditis: a systematic review and meta-analysis (Publications)
Introduction: The treatment of infective endocarditis (IE) is based on long intravenous administration of antibiotics. This is still a hard-to-die dogma. Throughout the years, different researchers ha
Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990-2021: findings from the Global... (Publications)
BACKGROUND: Stillbirth is a devastating and often avoidable adverse pregnancy outcome. Monitoring stillbirth levels and trends-in a comprehensive manner that leaves no one uncounted-is imperative for
Trends and levels of the global, regional, and national burden of appendicitis between 1990 and 2021: findings from the Global Burden of Disease Study... (Publications)
BACKGROUND: Appendicitis is a common surgical emergency that poses a large clinical and economic burden. Understanding the global burden of appendicitis is crucial for evaluating unmet needs and imple
[Preprint] In the shadow of Smith's invisible hand: risks to economic stability and social wellbeing in the age of intelligence (Publications)
Work is fundamental to societal prosperity and mental health, providing financial security, identity, purpose, and social integration. The emergence of generative artificial intelligence (AI) has cata
One-year impact of behavioural interventions on schistosomiasis-related knowledge, attitude and practices of primary schoolchildren in Pemba, Tanzania (Publications)
BACKGROUND: Elimination of schistosomiasis as a public health problem and interruption of transmission in selected areas are goals set by the World Health Organization for 2030. Behaviour change commu
Ambient air pollution exposure and incidence of cataract surgery: the prospective 3City-Alienor study (Publications)
PURPOSE: Cataract, the leading cause of blindness worldwide, is a multifactorial disease involving oxidative stress mechanisms. The aim of our study was to investigate the relationship between air pol
Meteorological factors, population immunity, and COVID-19 incidence: a global multi-city analysis (Publications)
OBJECTIVES: While COVID-19 continues to challenge the world, meteorological variables are thought to impact COVID-19 transmission. Previous studies showed evidence of negative associations between hig
Praziquantel and factor H recruitment differentially affect the susceptibility of <em>Schistosoma mansoni</em> to complement-mediated damage (Publications)
BACKGROUND: Schistosomes are highly efficient evaders of human immunity, as evident by their ability to survive in human blood for years. How they protect themselves against the constant attack by a k
