Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Antimalarial Drug Screening (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/antimalarial-drug-screening
performed by Medicines for Malaria Venture in 2009 and showed that OZ439 is well tolerated at all dose levels. So called 'proof of concept' phase II clinical trials with malaria patients showed that the [...] Our mandate with Medicines for Malaria Venture in Geneva comprises exploratory work on novel compounds from various sources. The goal is to identify novel chemical entities showing antimalarial activity [...] during the last decade is that such novel compounds can ultimately...
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance [...] in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination [...] techniques can be standardised, and identify the requirements for...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
rectal artesunate in settings where malaria mortality remains high. Without improving the entire continuum of care, children will continue to die from severe malaria and promising interventions will fail [...] Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting on [...] In October, 2022, we reported on the findings of the Community Access to Rectal...
Bite Interruption Towards Elimination (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/bite-interruption-towards-elimination
progress in reducing malaria transmission in the Greater Mekong Subregion (GMS). However progress has stalled with reports of increase in the number of cases, multi-drug resistant malaria and pyrethroid-resistant [...] mobile and migrant populations, including forest-goers and forest rangers. Many of the dominant malaria vectors in the region feed and rest outdoors yet there is limited available protection against mosquito [...] populations. To address these pressing challenges, the University...
Pre-referral rectal artesunate: no cure for unhealthy systems (Publications)
rectal artesunate in settings where malaria mortality remains high. Without improving the entire continuum of care, children will continue to die from severe malaria and promising interventions will fail [...] Pre-referral rectal artesunate suppositories can save the lives of children with severe malaria if patients receive adequate post-referral care. A multi-country randomised controlled trial reporting on [...] In October, 2022, we reported on the findings of the Community Access to Rectal...
Defining the next generation of <em>Plasmodium vivax</em> diagnostic tests for control and elimination: target product profiles (Publications)
prevalence of malaria has decreased over the past fifteen years, but similar gains have not been realized against Plasmodium vivax because this species is less responsive to conventional malaria control i [...] interventions aimed principally at P. falciparum. Approximately half of all malaria cases outside of Africa are caused by P. vivax. This species places dormant forms in human liver that cause repeated clinical [...] clinical attacks without involving another mosquito bite. The diagnosis...
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance [...] in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination [...] techniques can be standardised, and identify the requirements for...
New Antimalarial Drug Shows Promise (News)
https://www.swisstph.ch/en/news/news-detail/news/new-antimalarial-drug-shows-promise
Medicines for Malaria Venture (MMV), the Swiss Tropical and Public Health Institute (Swiss TPH) and other international researchers. "The ability of MMV048 to block all life-cycle stages of the malaria parasite [...] history in diseases of poverty. Malaria research has been a core focus since the institute's foundation in 1943. Today, some 200 specialists work on various aspects of malaria in Basel and abroad. Activities [...] parasite from person to person, suggests that this compound...
