Assessing caregivers' perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo (Publications)
BACKGROUND: Malaria remains a major public health issue in the Democratic Republic of the Congo (DRC), accounting for 44% deaths among outpatient visits in children
Accelerating the healing of hard-to-heal wounds with food supplements: nutritional analysis in the Côte d'Ivoire (Publications)
OBJECTIVE: Hard-to-heal wounds are an important, yet often neglected, public health issue in low- and middle-income countries (LMICs). Malnutrition has been identified as a risk factor for prolonged h
SARS-CoV-2 variants of concern in children and adolescents with COVID-19: a systematic review (Publications)
OBJECTIVES: Infections by SARS-CoV-2 variants of concern (VOCs) might affect children and adolescents differently than earlier viral lineages. We aimed to address five questions about SARS-CoV-2 VOC i
Resistance-informed versus empirical management of viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a... (Publications)
BACKGROUND: Children and adolescents with HIV taking antiretroviral therapy (ART) have high rates of viraemia. We assessed if genotypic resistance testing (GRT) to inform onward treatment improved tre
Association of air pollution with incidence of end-stage kidney disease in two large European cohorts (Publications)
End-stage kidney disease (ESKD) poses a high burden on patients and health systems. While numerous studies indicate an association between air pollution and chronic kidney disease, studies on ESKD are
Understanding drug exposure and <em>Trichuris trichiura</em> cure rates: a pharmacometric approach for albendazole-ivermectin co-medication in... (Publications)
BACKGROUND AND OBJECTIVE: Trichuriasis caused by the human whipworm Trichuris trichiura poses a significant public health concern. Albendazole-ivermectin co-medication is currently the most effective
Optimization of pyrazolopyridine 4-carboxamides with potent antimalarial activity for which resistance is associated with the <em>P. falciparum</em>... (Publications)
Emerging resistance to current antimalarials is reducing their effectiveness and therefore there is a need to develop new antimalarial therapies. Toward this goal, high throughput screens against the
Low tuberculosis treatment initiation after positive tuberculosis lipoarabinomannan results (Publications)
A positive urine TB-LAM result should lead to TB treatment initiation. TB treatment uptake was low after a positive TB-LAM but negative Xpert test. A lack of trust in TB-LAM results by clinicians and