Visual Analysis of Long Lasting Insecticidal Nets to Maximise Universal Access (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/visual-analysis-of-long-lasting-insecticidal-nets-to-maximise-universal-access
vital in reducing the malaria burden among children over the last 20 years. Reductions have stagnated and resources available for control are half what is needed to meet malaria control milestones. Standard [...] between products, influencing their value-for-money. This project will deliver information to National Malaria Control Programs (NMCP) that enables them to 1) select durable and cost-effective LLINs to buy, 2) [...] NMCP=medium to select the best LLINs for their setting to optimize the...
Clinical Immunology (Page)
https://www.swisstph.ch/en/about/mpi/clinical-immunology
First-generation malaria vaccine successfully implemented in three African countries. Lancet . 2024;403(10437):1607-1609. DOI: 10.1016/s0140-6736(23)02892-1 Day C.J et al. The essential malaria protein Pf CyRPA [...] well as host factors elicited by subunit and whole parasite vaccines against tuberculosis (TB) and malaria. Clinical trials are performed with our partners of the Ifakara Health Institute in Bagamoyo. Further [...] particularly TB. Unit researchers also work to understand the...
WHO TVC (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/who-tvc
Increasing coverage of malaria vector control interventions globally has led to significant reductions in disease burden. However due to its high recurrent cost, there is a need to determine if and when [...] reduced. We conduct literature reviews and simulate a mathematical model of Plasmodium falciparum malaria epidemiology to determine the impact of scaling back vector control on transmission and disease.
Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials (Publications)
against laboratory-resistant strains of malaria. Profiling of 19f suggested a fast in vitro killing profile. In vivo activity in a murine model of human malaria in a dose-dependent manner constitutes a
Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials (Publications)
against laboratory-resistant strains of malaria. Profiling of 19f suggested a fast in vitro killing profile. In vivo activity in a murine model of human malaria in a dose-dependent manner constitutes a
Dietary diversity in primary schoolchildren of south-central Côte d'Ivoire and risk factors for non-communicable diseases (Publications)
prediabetes and malaria infection, as well as medium and high DDS. Overweight was associated with malaria infection and moderate anaemia. CONCLUSION: Overweight, prediabetes, low HDL-C, malaria, and anaemia [...] the primary caretaker according to the guideline of Food and Agriculture Organization. Anaemia, malaria, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood [...] health in Taabo. Our findings highlight interactions between infectious...
Dietary diversity in primary schoolchildren of south-central Côte d'Ivoire and risk factors for non-communicable diseases (Publications)
prediabetes and malaria infection, as well as medium and high DDS. Overweight was associated with malaria infection and moderate anaemia. CONCLUSION: Overweight, prediabetes, low HDL-C, malaria, and anaemia [...] the primary caretaker according to the guideline of Food and Agriculture Organization. Anaemia, malaria, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and blood [...] health in Taabo. Our findings highlight interactions between infectious...
Comparative efficacy of Vector Guard® to Olyset® Plus insecticide-treated nets against strongly pyrethroid-resistant <em>Anopheles arabiensis</em> in... (Publications)
promising pyrethroid–PBO ITN for the control of resistant malaria vectors. The addition of Vector Guard® to the class of pyrethroid–PBO ITNs will enable malaria control programs to select cost-effective ITNs, improving [...] Introduction: The resistance of malaria vectors to pyrethroids has compromised the efficacy of pyrethroid insecticide-treated nets (ITNs). In response, ITNs with pyrethroids and piperonyl butoxide (PBO) [...] conducted to evaluate Vector Guard® relative to Olyset® Plus (a...
The impact of using primaquine without prior G6PD testing: a case series describing the obstacles to the medical management of haemolysis (Publications)
vivax malaria in glucose-6-phosphate dehydrogenase (G6PD) deficient individuals employs weekly primaquine dosing. This is the only recommended regimen for this patient sub-group. If national malaria programs [...] with unknown G6PD status from two different countries were prescribed primaquine as per national malaria program guidelines. During treatment both patients presented to the clinic with symptoms of anaemia
Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the <em>Plasmodium</em> life cycle (Publications)
Malaria is the one of the deadliest infectious diseases worldwide. Chemically, quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing [...] coordination with antimalarial quinolines is a potential chemical tool for drug design and discovery in malaria and other infectious diseases susceptible to quinoline treatment.
