Modeling human adaptive immune responses with tonsil organoids (Publications)
Most of what we know about adaptive immunity has come from inbred mouse studies, using methods that are often difficult or impossible to confirm in humans. In addition, vaccine responses in mice are o
Case-control study of individuals with discrepant nucleocapsid and spike protein SARS-CoV-2 IgG results (Publications)
BACKGROUND: Laboratory-based methods for SARS-CoV-2 antibody detection vary widely in performance. However, there are limited prospectively-collected data on assay performance, and minimal clinical in
Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues (Publications)
Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult org
Plasma as an alternative COVID-19 diagnostic specimen in a hospitalized patient negative for SARS-CoV-2 by nasopharyngeal swab (Publications)
We present the case of an inpatient with pneumonia and repeatedly negative nasopharyngeal SARS-CoV-2 testing. In such challenging cases, alternative diagnostic options include lower respiratory tract
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity (Publications)
The development of a portfolio of COVID-19 vaccines to vaccinate the global population remains an urgent public health imperative(1). Here we demonstrate the capacity of a subunit vaccine, comprising
Health system resilience: a critical review and reconceptualisation (Publications)
This Viewpoint brings together insights from health system experts working in a range of settings. Our focus is on examining the state of the resilience field, including current thinking on definition
Investigating sustainability challenges for the National Health Insurance Fund in Tanzania: a modelling approach (Publications)
OBJECTIVE: This study aimed to model the long-term cost associated with expanding public health insurance coverage in Tanzania. DESIGN, SETTING AND PARTICIPANTS: We analysed the 2016 claims of 2 923 5
A multi-pronged approach to improve blood culture diagnostics in different clinical departments: a single-centre experience (Publications)
PURPOSE: Blood culture (BC) diagnostics are influenced by many factors. We performed a targeted interdisciplinary analysis to analyse effects of various measures on BC diagnostics performance. METHODS
Understanding diarrhoeal diseases in response to climate variability and drought in Cape Town, South Africa: a mixed methods approach (Publications)
BACKGROUND: The climate of southern Africa is expected to become hotter and drier with more frequent severe droughts and the incidence of diarrhoea to increase. From 2015 to 2018, Cape Town, South Afr
Comparison of ambient radiofrequency electromagnetic field (RF-EMF) levels in outdoor areas and public transport in Switzerland in 2014 and 2021 (Publications)
Mobile communication technology has evolved rapidly over the last ten years with a drastic increase in wireless data traffic and the deployment of new telecommunication technologies. The aim of this s
