Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on... (Publications)
and killing effects of LLINs on both susceptible and pyrethroid resistant malaria vectors to estimate the protection against malaria transmission-in terms of vectorial capacity (VC)-provided by each net cohort [...] BACKGROUND: Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under [...] contributions of these different interrelated factors to durability of...
Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in Cambodia (Publications)
some populations have recently experienced dramatic declines in malaria, the majority of those most at risk of Plasmodium falciparum malaria still lack access to effective treatment with artemisinin combination [...] which, in many countries, plays an important role in the provision of malaria treatment. The Affordable Medicines Facility for malaria (AMFm) is a recent initiative that aims to increase the provision of
Spatial mapping and prediction of <em>Plasmodium falciparum</em> infection risk among school-aged children in Côte d'Ivoire (Publications)
school-aged children in Cote d'Ivoire represent the most up-to-date malaria risk maps. These tools can be used for spatial targeting of malaria control interventions. [...] BACKGROUND: In Cote d'Ivoire, malaria remains a major public health issue, and thus a priority to be tackled. The aim of this study was to identify spatially explicit indicators of Plasmodium falciparum [...] ownership and household characteristics. Children were interviewed for preventive measures against malaria....
Leptospira seroprevalence and risk factors in health centre patients in Hoima District, Western Uganda (Publications)
consented participants. Overall, 69% reported having fever in the past year, with 49% reporting malaria, 14% malaria relapse, 6% typhoid fever, 3% brucellosis, and 0% leptospirosis. We tested sera by microscopic [...] Nigeria (serogroup Pyrogenes). Probable recent leptospirosis was associated with having self-reported malaria within the past year (p = 0.048). Higher risk activities included skinning cattle (n = 6) with 12 [...] serogroup). Leptospirosis should be a diagnostic consideration in...
Attrition, physical integrity and insecticidal activity of long-lasting insecticidal nets in sub-Saharan Africa and modelling of their impact on... (Publications)
and killing effects of LLINs on both susceptible and pyrethroid resistant malaria vectors to estimate the protection against malaria transmission-in terms of vectorial capacity (VC)-provided by each net cohort [...] BACKGROUND: Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under [...] contributions of these different interrelated factors to durability of...
Promising Antimalarial Drug Proves Ineffective at Saving Children’s Lives (News)
https://www.swisstph.ch/en/news/news-detail/news/promising-antimalarial-drug-proves-ineffective-at-saving-childrens-lives
continue to die from malaria, and promising interventions such as RAS will fail to meet their full potential.” About the study The Community Access to Rectal Artesunate for Malaria (CARAMAL) project was [...] antimalarial drug, proves ineffective at saving the lives of young children suffering from severe malaria, according to the results of a new study conducted by the Swiss Tropical and Public Health Institute [...] under real-world conditions, RAS did not improve the odds of survival for...
Antiparasitic agents: new drugs on the horizon (Publications)
the currently available medicines. Public-private partnerships aiming to develop new medicines for malaria and sleeping sickness have, over the past 12 years, brought forward several drug candidates that [...] compounds against trypanosomes and other parasites. Thus, finally, new therapeutic agents against malaria and sleeping sickness are within reach
KALUMI - A Phase 2 Study on KAF156-Lumefantrine-SDF for acute uncomplicated Plasmodium falciparum in children (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/kalumi-a-phase-2-study-on-kaf156-lumefantrine-sdf-for-acute-uncomplicated-plasmodium-falciparum-in-children
KAF156 and Lumefantrine-SDF combination in the treatment of acute uncomplicated Plasmodium falciparum Malaria. This study aims to confirm the efficacy, safety and tolerability of KLU156, a fixed dose combination [...] and children ≥ 5 kg body weight and ≥ 2 months of age suffering from uncomplicated P. falciparum malaria (with or without other Plasmodium spp. co-infection).
Antiparasitic agents: new drugs on the horizon (Publications)
the currently available medicines. Public-private partnerships aiming to develop new medicines for malaria and sleeping sickness have, over the past 12 years, brought forward several drug candidates that [...] compounds against trypanosomes and other parasites. Thus, finally, new therapeutic agents against malaria and sleeping sickness are within reach
Antimalarial lead-optimization studies on a 2,6-imidazopyridine series within a constrained chemical space to circumvent atypical dose-response curves... (Publications)
falciparum NODscidIL2Rgammanull mouse malaria infection model. The observation of atypical dose-response curves when some compounds were tested against multidrug resistant malaria parasite strains guided the o
