High proportions of asymptomatic and submicroscopic <em>Plasmodium vivax </em>infections in a peri-urban area of low transmission in the Brazilian... (Publications)
regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. [...] conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were [...] carried gametocytes and presented low asexual parasitemia. This reservoir actively...
Feasibility of repellent use in a context of increasing outdoor transmission: a qualitative study in rural Tanzania (Publications)
long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has substantially reduced malaria morbidity and mortality in sub-Saharan Africa. These tools target indoor resting and biting vectors [...] may select for vectors that bite and rest outdoors. Thus, to significantly impact this residual malaria transmission outdoors, tools targeting outdoor transmission are required. Repellents, used for personal [...] hinges upon its community acceptability. This study assessed the...
Estimating the duration of Plasmodium falciparum infection from trials of indoor residual spraying (Publications)
cross-sectional survey data collected from three historical trials of indoor residual spraying against malaria: one from two contiguous districts in Tanzania-Kenya (Pare Taveta) carried out in 1954, the others [...] showed considerable variation but no general age trend. There was also no clear relationship between malaria endemicity and infection duration. Analyses of successive sampling from the same individuals with [...] areas. Periods of several years may be required to evaluate long-term...
Innovative tools and OpenHDS for health and demographic surveillance on Rusinga Island, Kenya (Publications)
METHODS: A large trial investigating the effect of odour-baited mosquito traps on malaria vector populations and malaria transmission on Rusinga Island, western Kenya, has deployed an HDSS. By means of [...] DISCUSSION: Adopting innovative technological advancements has enabled the collection of demographic and malaria data quickly and effectively, with minimal margin for errors. Real-time data quality controls integrated
The practical importance of permanent and semipermanent habitats for controlling aquatic stages of <em>Anopheles gambiae</em> <em>sensu lato</em>... (Publications)
aquatic-stage Anopheles is one of the oldest and most historically successful interventions to prevent malaria, but it has seen little application in Africa. Consequently, the ecology of immature afrotropical [...] examine the relative importance and availability of different larval habitats in an area of perennial malaria transmission in preparation for a pilot-scale larval control programme. The study was conducted in [...] types, regardless of permanence. All potential breeding sites need to...
<em>Plasmodium falciparum</em> merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic... (Publications)
allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates. The aim of the current study is to characterize the immune response (epitope [...] (epitope mapping) in naturally exposed individuals and relate immune responses to the risk of clinical malaria. METHODS: To optimize their construction, the fine specificity of human serum antibodies from donors [...] response to individual epitopes within the 3D7 family-specific region...
Spatial risk profiling of <em>Plasmodium falciparum</em> parasitaemia in a high endemicity area in Côte d'Ivoire (Publications)
in a high endemicity area of Africa, and to specify how this information can facilitate improved malaria control at the district level. METHODS: A questionnaire was administered to about 4,000 schoolchildren [...] parasitaemia. After accounting for spatial correlation, age, bed net coverage, rainfall during the main malaria transmission season and distance to rivers remained significant covariates. CONCLUSION: It is argued [...] villages in close proximity to rivers, in concert with other...
Evaluation of anopheline diversity and abundance across outdoor collection schemes utilizing CDC light traps in Nchelenge District, Zambia (Publications)
In the global fight against malaria, standard vector control methods such as indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are intended to protect inside residential structures and [...] may be exposed to outdoors. Nchelenge District in northern Zambia experiences persistently high malaria transmission even with ITNs and IRS in place. However, very few studies have examined outdoor vector [...] including a number of infectious An. funestus, may partially explain the...
Further development of simulations of Plasmodium falciparum interventions and their integration with the needs of stakeholders (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/further-development-of-simulations-of-plasmodium-falciparum-interventions-and-their-integration-with-the-needs-of-stakeholders
platform for comparing, fitting, and evaluating different individual-based stochastic simulations of malaria epidemiology. Aims In the next phase of the project, we propose to exploit the functionality of this [...] potential clients, and develop capacity to anticipate and react promptly to requests from the R & D and malaria intervention communities.
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase)
