A community-randomized evaluation of the effect of intermittent preventive treatment in infants on antimalarial drug resistance in southern Tanzania (Publications)
is the administration of sulphadoxine-pyrimethamine (SP) at 2, 3 and 9 months of age to prevent malaria. We investigated the influence of IPTi on drug resistance.Methods. Twenty-four areas were randomized [...] did not increase drug pressure, or the selection on dhfr and dhps mutants, when SP was first line malaria treatment. Introduction of artemether-lumefantrine was followed by an increase in dhfr mutations
Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals [...] age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and
Anti-trypanosomatid and antiplasmodial activities of alkaloids from <em>Hippeastrum</em> species (Publications)
tid parasites like human African trypanosomiasis (HAT), Chagas disease (CD), leishmaniasis, and malaria are persistent health problems in developing countries that still demand new drug development. The [...] tid parasites as a lead compound for the development of alternative treatments for HAT, CD, and malaria.
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
isolates and lab-raised drug-resistant strains of Pf. It was efficacious in the humanized NSG mouse malaria infection model at a single oral dose of 32 mg/kg. This compound was nonteratogenic in the zebrafish [...] human dose, indicating that this series has the potential to deliver a preclinical candidate for malaria.
Mathematical Epidemiology (Page)
https://www.swisstph.ch/en/about/eph/disease-modelling/mathematical-epidemiology
computational models to improve understanding of population, infection and disease dynamics, focusing on malaria and neglected tropical diseases. Nakul Chitnis PhD, PD Dr. Group Leader +41612848242 nakul.chitn [...] Maximilian Richter Fabian Schär Taru Singhal Swapnoleena Ventura Sen Selected Projects All Projects Core Malaria Modelling Genetic composition of Plasmodium falciparum infections in Zanzibar, travel and transmission: [...] package to interface mosquito bionomics, human exposure and...
Proteomic analysis of exported chaperone/co-chaperone complexes of <em>P. falciparum</em> reveals an array of complex protein-protein interactions (Publications)
Malaria parasites modify their human host cell, the mature erythrocyte. This modification is mediated by a large number of parasite proteins that are exported to the host cell, and is also the underlying [...] underlying cause for the pathology caused by malaria infection. Amongst these proteins are many Hsp40 co-chaperones, and a single Hsp70. These proteins have been implicated in several processes in the host cell
Combining synthetic human odours and low-cost electrocuting grids to attract and kill outdoor-biting mosquitoes: field and semi-field evaluation of an... (Publications)
BACKGROUND: On-going malaria transmission is increasingly mediated by outdoor-biting vectors, especially where indoor insecticidal interventions such as long-lasting insecticide treated nets (LLINs) are [...] dusk and dawn. MLBs fitted with one, two or three electrocuting grids were compared outdoors in a malaria endemic village in Tanzania, where vectors had lost susceptibility to pyrethroids. MLBs with three
In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants (Publications)
Eight extracts from seven selected Cameroonian medicinal plants, traditionally used to treat malaria and other protozoal diseases, were tested in vitro for their antiprotozoal activities against Plasm [...] Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei rhodesiense, protozoa responsible for malaria, visceral leishmaniasis, Chagas disease and African trypanosomiasis, respectively. The most active
Cytotoxic T lymphocyte (CTL) low-responsiveness to the <em>Plasmodium falciparum</em> circumsporozoite protein in naturally-exposed endemic... (Publications)
epitope(s) within the circumsporozoite (CS) protein of malaria sporozoites have been shown to play an important role in protective immunity against malaria, at least in murine models. Their role in sporozoite
Health & demographic surveillance system profile: the Taabo Health and Demographic Surveillance System, Côte d'Ivoire (Publications)
ed diseases such as schistosomiasis and malaria. The Taabo HDSS has generated setting-specific evidence on the impact of targeted interventions against malaria, schistosomiasis and other neglected tropical
