Medical Parasitology and Infection Biology | Departments of Swiss TPH (Page)
https://www.swisstph.ch/en/about/mpi
these biological processes, we hope to contribute to the control of diseases of poverty such as malaria, tuberculosis, trypanosomiasis, dengue, Buruli ulcer and helminth infections. Research on Pathogen [...] gagneux@swisstph.ch Clinical Immunology Gene Regulation Helminth Drug Development Helminth Immunology Malaria Host Interactions Parasite Chemotherapy Unit Tuberculosis Ecology and Evolution Unit Tuberculosis [...] Units and Groups Clinical Immunology Gene Regulation Helminth Drug...
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
The effect of <em>Plasmodium falciparum</em> exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in... (Publications)
BACKGROUND: The RTS,S/AS01(E) malaria vaccine showed lower antibody response and protective efficacy in infants aged 6-12 weeks compared with children aged 5-17 months (for whom this vaccine is recommended) [...] antibody immunoglobulin G (IgG) responses measured by ELISA and pre-vaccination serological markers of malaria exposure by assessing the IgG levels against 1000 P falciparum antigens using partial proteome m [...] The negative effect of maternal anti-CSP IgG in infants did not appear to...
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
The effect of <em>Plasmodium falciparum</em> exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in... (Publications)
BACKGROUND: The RTS,S/AS01(E) malaria vaccine showed lower antibody response and protective efficacy in infants aged 6-12 weeks compared with children aged 5-17 months (for whom this vaccine is recommended) [...] antibody immunoglobulin G (IgG) responses measured by ELISA and pre-vaccination serological markers of malaria exposure by assessing the IgG levels against 1000 P falciparum antigens using partial proteome m [...] The negative effect of maternal anti-CSP IgG in infants did not appear to...
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Inference for entomological semi-field experiments: fitting a mathematical model assessing personal and community protection of vector-control... (Publications)
and metofluthrin spatial repellents, as well as combined interventions for Plasmodium falciparum malaria in Anopleles minimus. Overall, all interventions had both personal and community effects, preventing [...] than just reduction in biting, to be parameterised and highlights the tools assessed as promising malaria interventions.
Acceptability and use of insecticide impregnated bednets in northern Ghana (Publications)
washing soaps could improve protection for young children. The success of the promotion of IIBNs in malaria control programmes will depend on the cost of the package and the time of year that it is delivered [...] the intervention in this study, and it should be included as an important component of national malaria control programmes.
drLumi: an open-source package to manage data, calibrate, and conduct quality control of multiplex bead-based immunoassays data analysis (Publications)
bead-based immunoassay in a study aiming to measure correlates of risk or protection from malaria of the RTS,S malaria vaccine nested in the Phase 3 randomized controlled trial of this vaccine.
