The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data (Publications)
therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing strategy on efficacy in a pooled analysis from trials done in a wide range of malaria-endemic settings [...] dose of artemether-lumefantrine provides reliable efficacy in most patients with uncomplicated malaria. However, therapeutic efficacy was lowest in young children from Asia and young underweight children
A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma (Publications)
determinants of treatment response, the achievement of sufficient blood levels is essential for curing malaria. For helping us at improving our current understanding of antimalarial drugs pharmacokinetics, efficacy [...] their metabolites which are the components of the current first-line combination treatments for malaria (artemether, artesunate, dihydroartemisinin, amodiaquine, N-desethyl-amodiaquine, lumefantrine, [...] endoperoxide-containing antimalarials in the presence of hemolysis was...
Effect of vitamin A supplementation on morbidity due to <em>Plasmodium falciparum</em> in young children in Papua New Guinea: a randomised trial (Publications)
BACKGROUND: Many individuals at risk of malaria also have micronutrient deficiencies that may hamper protective immunity. Vitamin A is central to normal immune function, and supplementation has been shown [...] morbidity of some infectious diseases. We investigated the effect of vitamin A supplementation on malaria morbidity. METHODS: This randomised double-blind placebo-controlled trial of vitamin A supplementation [...] randomly assigned high-dose vitamin A (n=239) or placebo (n=241), every 3...
Science Publication: SARS-CoV-2 Genomic Surveillance in Africa (News)
https://www.swisstph.ch/en/science-publication-sars-cov-2-genomic-surveillance-in-africa
set up the Baney Public Health Laboratory as part of the Equatoguinean Malaria Vaccine Initiative to work on the development of malaria vaccines. This laboratory was implemented as early as January 2020 by [...] Africa CDC, WHO AFRO and 300 other institutions across the continent, including Swiss TPH. From Malaria Vaccine Development to SARS-CoV-2 Screening Swiss TPH and partners from Equatorial Guinea contributed
Mansonella perstans-Filariose nach Aufenthalt in Kamerun. 19-jährige Patientin, geboren in Kamerun, seit zehn Jahren in der Schweiz (Publications)
g pain in the lower abdomen, predominantly on the right side. A blood smear tested for presumed malaria showed subperiodic microfilariae of the species Mansonella perstans. The patient was treated with
Mansonella perstans-Filariose nach Aufenthalt in Kamerun. 19-jährige Patientin, geboren in Kamerun, seit zehn Jahren in der Schweiz (Publications)
g pain in the lower abdomen, predominantly on the right side. A blood smear tested for presumed malaria showed subperiodic microfilariae of the species Mansonella perstans. The patient was treated with
30 Years of R&D Towards New Drugs for Tropical Diseases (Page)
https://www.swisstph.ch/en/impact-stories/30-years-of-rd-towards-new-drugs-for-tropical-diseases
human African trypanosomiasis and schistosomiasis) and other infectious diseases of poverty (e.g. malaria and tuberculosis), there was no choice. As their name implies, neglected tropical diseases and infectious [...] expertise emerged as a game-changer. By collaborating with partners, including Novartis, Medicines for Malaria Venture (MMV) and Drugs for Neglected Diseases initiative (DNDi), Swiss TPH played a vital role in [...] Importantly, three of the eight MDGs pertained to health, and MDG...
Turmhaus-Talks - Die Vortragsreihe für gesundes Reisen und Leben (Page)
https://www.swisstph.ch/en/about/events/turmhaus-talks
Reisemedizin Flyer Vortragsreihe Der lange Weg zum Malaria-Impfstoff: Durchbruch mit Hindernissen Mittwoch, 4. Dezember 2024, 18:00-19:00 Uhr Malaria hat die Menschheitsgeschichte geprägt und Spuren im [...] Jahre, bis der erste Impfstoff gegen Malaria zugelassen wurde. Jetzt wollen afrikanische Länder den Impfstoff massiv einsetzen. Rückt damit eine Welt ohne Malaria in greifbare Nähe? Erfahren Sie, welche
Synthesis of szentiamide, a depsipeptide from entomopathogenic <em>Xenorhabdus szentirmaii</em> with activity against <em>Plasmodium falciparum</em> (Publications)
on of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria
Synthesis of szentiamide, a depsipeptide from entomopathogenic <em>Xenorhabdus szentirmaii</em> with activity against <em>Plasmodium falciparum</em> (Publications)
on of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria
