Identification of an <em>Onchocerca volvulus</em> cDNA encoding a low-molecular-weight antigen uniquely recognized by onchocerciasis patient sera (Publications)
a lambda gt11 cDNA expression library derived from microfilariae-producing female O. volvulus. The open reading frame encodes 152 amino acids, and the deduced sequence predicts a Mr of 16,850 (consistent
A primaquine-chloroquine hybrid with dual activity against <em>Plasmodium</em> liver and blood stages (Publications)
Based on the optimized synthetic pathway, the compound is accessible in a smooth and versatile way and open for potential further molecular modification.
Synthesis and antiplasmodial activity of new N-[3-(4-{3-[(7-chloroquinolin-4-yl)amino]propyl}piperazin-1-yl)propyl]carboxamides (Publications)
-aminopropyl)piperazin-1-yl]propyl}-7-chloroquinolin-4-amine with polymer-bound carboxylic acids opened straightforward access to novel aminoquinolines with activity against Plasmodium falciparum strains
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation (Publications)
diffusible lipid secreted by the human pathogen Mycobacterium ulcerans, which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show that mycolactone operates by hijacking the
Targeting <em>Plasmodium</em> PI(4)K to eliminate malaria (Publications)
ylinositol-4-phosphate. Collectively, our data define PI(4)K as a key Plasmodium vulnerability, opening up new avenues of target-based discovery to identify drugs with an ideal activity profile for the
Retention in care and virological failure among adult HIV+ patients on second-line ART in Rwanda: a national representative study (Publications)
METHODS: A two-stage cluster sampling design was undertaken. 49 of 340 health facilities linked to the open-source electronic medical record (EMR) system of Rwanda were randomly sampled. Data sampling criteria
Model-based integration of genomics and metabolomics reveals SNP functionality in <em>Mycobacterium tuberculosis</em> (Publications)
the antibiotic para-aminosalicylic acid. Our method is broadly applicable across microbial life, opening possibilities for the development of more selective treatment strategies.
Assessing the Potential Health Impact of Omicron (Page)
https://www.swisstph.ch/en/news/assessing-the-potential-health-impact-of-omicron
Modelling unit has been setting up an open-access transmission model for COVID-19 since the beginning of the pandemic, building on its experience in malaria modelling. “Our OpenCOVID transmission model provides
Clinical Research | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/med/clinical-research
viraemia in children and adolescents with HIV in Lesotho and Tanzania (GIVE MOVE trial): a multisite, open-label randomised controlled trial. Lancet Glob Health . 2024;12(8):e1312-e1322. DOI: 10.1016/s221 [...] factors for developing active tuberculosis among people living with HIV in Georgia 2019-2020 cohort. Open Forum Infect Dis . 2024;11(9):ofae466. DOI: 10.1093/ofid/ofae466 Related Topics Infectious Diseases
“We have to seek out risks in order to improve prevention.” (News)
https://www.swisstph.ch/en/news/news-detail/news/we-have-to-seek-out-risks-in-order-to-improve-prevention
We can map a person’s lifestyle or gain information about their social networks.” These were the opening remarks of epidemiologist and public-health specialist Nicole Probst-Hensch from the Swiss Tropical [...] methods to determine the risks for individual illnesses: “Research in the age of precision medicine will open up a completely new mechanistic, causal understanding of illnesses and wellness.” The issue of pe