Antiparasitic chaiyaphumines from entomopathogenic <em>Xenorhabdus</em> sp. PB61.4 (Publications)
(1) showed good activity against Plasmodium falciparum (IC50 of 0.61 muM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines (Publications)
some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested
Global health at a crossroads: Who will fill the gap? (Page)
https://www.swisstph.ch/en/impact-stories/global-health-at-a-crossroads-who-will-fill-the-gap
communities: Malaria research and control in Tanzania : Our long-standing partner, the Ifakara Health Institute (IHI), will lose a USD 17.9 million USAID grant, endangering progress towards malaria elimination [...] health programmes are being scaled back or shut down. Millions of people who rely on HIV treatment, malaria prevention or neglected tropical disease (NTD) control are being left behind. Photo credit: Riccardo [...] single donor can fill. Major funding institutions are scaling back :...
Impact Stories | Swiss TPH (Page)
https://www.swisstph.ch/en/impact-stories
research. Read more 22.04.2021 Julia Richter, Swiss Malaria Group World Malaria Day 2021: In the shadows of the COVID-19 pandemic A world without malaria is within reach. At the same time, the COVID-19 pandemic [...] progress in the fight against malaria. This year's World Malaria Day on 25 April 2021 will draw attention to the fact that further efforts are needed to achieve the goal of a malaria-free world. Read more 21 [...] years, much has been invested in malaria prevention and...
Modified 5'-trityl nucleosides as inhibitors of <em>Plasmodium falciparum</em> dUTPase (Publications)
dine triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors
Novel nucleoside-based antimalarial compounds (Publications)
The malaria-causing parasite Plasmodium falciparum employs a salvage pathway for the biosynthesis of nucleotides, in contrast to de novo biosynthesis that is utilized by the human host. A series of twenty-two
Prévention des infections chez les voyageurs immunosupprimés (Publications)
While traveling, patients may be exposed to several infections, such as traveler's diarrhea or malaria, which can be associated with a high rate of complications in this population. An appropriate strategy
<em>Plasmodium</em> gene regulation: far more to factor in (Publications)
Gene expression in the malaria parasite has received generous attention over the past several decades, predominantly because of the importance of var gene regulation, which is key to antigenic variation
Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in <em>Plasmodium falciparum</em> (Publications)
The malaria parasite Plasmodium falciparum undergoes antigenic variation to evade host immune responses through switching expression of variant surface proteins encoded by the var gene family. We demonstrate
