Quantifying the evolution and impact of antimalarial drug resistance: drug use, spread of resistance, and drug failure over a 12-year period in Papua... (Publications)
key factor driving drug resistance and reduced treatment effectiveness in Plasmodium falciparum malaria, but there are few formal, quantitative analyses of this process. METHODS. We analyzed drug usage
Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against <em>Plasmodium falciparum</em> merozoite antigens (Publications)
BACKGROUND: Malaria is a major global cause of deaths and a vaccine is urgently needed. RESULTS: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA, and coupled
Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in <em>Anopheles arabiensis</em> sampled from an... (Publications)
compromise the use of insecticides for the control of vector-borne diseases. The tolerance of the malaria vector, Anopheles arabiensis to deltamethrin was determined in a field population from a cotton-growing
Klaus Reither (People)
https://www.swisstph.ch/en/staff/profile/people/klaus-reither
Medical Research Programme, Tanzania/LMU Munich, Germany 2005-2006 Study Coordinator. Northern Region Malaria Project, Ghana/Charité Berlin - Other 1993 - 2005 Internal Medicine and Radiology
Pharmacomodulation of the redox-active lead plasmodione: synthesis of substituted 2-benzylnaphthoquinone derivatives, antiplasmodial activities, and... (Publications)
Malaria remains a major global health problem that has been exacerbated by the impact of the COVID-19 pandemic on health systems. To combat this, the World Health Organization (WHO) has set a target of
Start of an Implementation Research Course in Bukavu (News)
care system in the region since decades, spanning from new medication for the sleeping sickness, malaria control efforts and the improvement of health care. In the past years the Swiss TPH has evaluated
Drug repurposing in the chemotherapy of infectious diseases (Publications)
attack that are divergent share common ancestry (e.g., prokaryotic targets in the apicoplast of malaria parasites), whereas those that are convergent arise from a shared lifestyle (e.g., the susceptibility
"It Is a Race Against Time." An Interview with Claudia Daubenberger on Establishing a Diagnostic Lab for Sars-CoV-2 in Equatorial Guinea (News)
https://www.swisstph.ch/en/news/news-detail/news/it-is-a-race-against-time-an-interview-with-claudia-daubenberger-on-establishing-a-diagnostic-lab-for-sars-cov-2-in-equatorial-guinea
years. We have established one of the best-equipped laboratories in the region in order to conduct malaria vaccination research with our governmental partners, the Ifakara Health Institute (IHI), Sanaria [...] The laboratory was set up with the sole purpose to conduct epidemiological and clinical studies on malaria, and our plan was to develop it into a national reference laboratory within the next few years. However [...] been interrupted. This is devastating for population health, also when it...
The cost-effectiveness of permethrin impregnated bednets in preventing child mortality in Kassena-Nankana district of Northern Ghana (Publications)
bednets are now being widely promoted as an effective means of protecting African children against malaria, but there is little evidence of their cost-effectiveness. The impact on child mortality of introducing
Chemoproteomics validates selective targeting of <em>Plasmodium</em> M1 alanyl aminopeptidase as an antimalarial strategy (Publications)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metal
