3-Benzylmenadiones and their heteroaromatic analogues target the apicoplast of apicomplexa parasites: synthesis and bioimaging studies (Publications)
activity of plasmodione and related analogues are potentially associated with these two organelles in malaria parasites.
Genetic validation of <em>Pf</em>FKBP35 as an antimalarial drug target (Publications)
Plasmodium falciparum accounts for the majority of over 600,000 malaria-associated deaths annually. Parasites resistant to nearly all antimalarials have emerged and the need for drugs with alternative
Molecular epidemiology and genetic diversity of disappearing <em>Plasmodium vivax</em> in southern Thailand (Publications)
The evolution of genetic diversity and population structure of Plasmodium vivax as malaria elimination approaches remains unclear. This study analyzed the genetic variation and molecular epidemiology of
A potent and selective reaction hijacking inhibitor of <em>Plasmodium falciparum</em> tyrosine tRNA synthetase exhibits single dose oral efficacy... (Publications)
ML471 is well-tolerated and shows single dose oral efficacy in the SCID mouse model of P. falciparum malaria. We confirm that ML471 is a reaction hijacking inhibitor that is converted into a tight binding Tyr-ML471
Integral solvent-induced protein precipitation for target-engagement studies in <em>Plasmodium falciparum</em> (Publications)
mechanism of action (MoA) of several antimalarials and the rise of drug resistance toward existing malaria therapies emphasizes the need for new strategies to uncover the molecular target of compounds in
Design, synthesis and evaluation of praziquantel analogues and new molecular hybrids as potential antimalarial and anti-schistosomal agents (Publications)
Malaria and schistosomiasis are two of the neglected tropical diseases that persistently wreak havoc worldwide. Although many antimalarial drugs such as chloroquine are readily available, the emergence
Expert Committee Memberships | Scientific and Policy Advice (Page)
https://www.swisstph.ch/en/about/memberships
international organisations such as the WHO on evidence-based health policy. Sabina Beatrice Swiss Malaria Group (SMG) Leah Bohle Medical Anthropology Switzerland (MAS); Parlamentarische Gruppe sexuelle [...] International Health Iris Haueter Institut für Führung und Psychologie (IFP) Manuel Hetzel Swiss Malaria Group (President); BC Executive Committee, PNG Institute of Medical Research; Buttressing Coalition [...] Coalition, PNG Institute of Medical Research (BC); Fakultätsversammlung Phil...
Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana <em>Ancistrocladus abbreviatus</em> with inhibitory... (Publications)
e compounds. Some of the alkaloids of A. abbreviatus exhibited promising activities against the malaria parasite Plasmodium falciparum and PANC-1 human pancreatic cancer cells.
Setting priorities for knowledge translation of Cochrane reviews for health equity: evidence for equity (Publications)
with high burdens of disease globally, were selected for the pilot: diabetes/obesity, HIV/AIDS, malaria, nutrition, and mental health/depression. For each topic area, a "stakeholder panel" was assembled
Amplicon deep sequencing improves <em>Plasmodium falciparum</em> genotyping in clinical trials of antimalarial drugs (Publications)
Clinical trials monitoring malaria drug resistance require genotyping of recurrent Plasmodium falciparum parasites to distinguish between treatment failure and new infection occurring during the trial
